Gene description for HES7
Gene name hes family bHLH transcription factor 7
Gene symbol HES7
Other names/aliases SCDO4
bHLHb37
Species Homo sapiens
 Database cross references - HES7
ExoCarta ExoCarta_84667
Vesiclepedia VP_84667
Entrez Gene 84667
HGNC 15977
MIM 608059
UniProt Q9BYE0  
 HES7 identified in sEVs derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for HES7
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA binding GO:0003677 NAS
    protein binding GO:0005515 IPI
    protein dimerization activity GO:0046983 IEA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    skeletal system development GO:0001501 IEA
    somitogenesis GO:0001756 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    Notch signaling pathway GO:0007219 IEA
    mesoderm development GO:0007498 NAS
    anterior/posterior pattern specification GO:0009952 IBA
    post-anal tail morphogenesis GO:0036342 IEA
    rhythmic process GO:0048511 IEA
    regulation of neurogenesis GO:0050767 IBA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 NAS
 Experiment description of studies that identified HES7 in sEVs
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for HES7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 PIH1D2  
Two-hybrid Homo sapiens
3 TCEANC  
Two-hybrid Homo sapiens
4 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
5 QARS 5859
Two-hybrid Homo sapiens
6 PRPF31 26121
Two-hybrid Homo sapiens
7 DDX58 23586
Affinity Capture-RNA Homo sapiens
8 TCEA2  
Two-hybrid Homo sapiens
9 OSTF1 26578
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which HES7 is involved
PathwayEvidenceSource
Developmental Biology IEA Reactome
Formation of paraxial mesoderm IEA Reactome
Gastrulation IEA Reactome
Somitogenesis IEA Reactome





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