Gene description for PRSS12
Gene name protease, serine, 12 (neurotrypsin, motopsin)
Gene symbol PRSS12
Other names/aliases BSSP-3
BSSP3
MRT1
Species Homo sapiens
 Database cross references - PRSS12
ExoCarta ExoCarta_8492
Vesiclepedia VP_8492
Entrez Gene 8492
HGNC 9477
MIM 606709
UniProt P56730  
 PRSS12 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PRSS12
Molecular Function
    serine-type peptidase activity GO:0008236 TAS
Biological Process
    exocytosis GO:0006887 ISS
Subcellular Localization
    plasma membrane GO:0005886 ISS
    axon GO:0030424 ISS
    dendrite GO:0030425 IBA
    cytoplasmic vesicle GO:0031410 IEA
    synaptic cleft GO:0043083 IBA
    terminal bouton GO:0043195 IBA
    Schaffer collateral - CA1 synapse GO:0098685 IEA
    presynapse GO:0098793 IDA
    glutamatergic synapse GO:0098978 IDA
 Experiment description of studies that identified PRSS12 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PRSS12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 INS 3630
Affinity Capture-MS Homo sapiens
3 MFAP5  
Affinity Capture-MS Homo sapiens
4 CCL3  
Affinity Capture-MS Homo sapiens
5 PRG2  
Affinity Capture-MS Homo sapiens
6 PPIL3 53938
Affinity Capture-MS Homo sapiens
7 PDGFRA 5156
Affinity Capture-MS Homo sapiens
8 MSMB  
Affinity Capture-MS Homo sapiens
9 EPDR1 54749
Affinity Capture-MS Homo sapiens
10 CNTLN 54875
Affinity Capture-MS Homo sapiens
11 SCGB2A2  
Affinity Capture-MS Homo sapiens
12 NOTCH2 4853
Affinity Capture-MS Homo sapiens
13 PRPF40A 55660
Affinity Capture-MS Homo sapiens
14 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
15 SOX2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PRSS12 is involved
No pathways found





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