Gene description for FHDC1
Gene name FH2 domain containing 1
Gene symbol FHDC1
Other names/aliases -
Species Homo sapiens
 Database cross references - FHDC1
ExoCarta ExoCarta_85462
Vesiclepedia VP_85462
Entrez Gene 85462
HGNC 29363
UniProt Q9C0D6  
 FHDC1 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for FHDC1
Molecular Function
    actin binding GO:0003779 ISS
    microtubule binding GO:0008017 ISS
Biological Process
    actin filament polymerization GO:0030041 IBA
    stress fiber assembly GO:0043149 IDA
    cilium assembly GO:0060271 IMP
    Golgi ribbon formation GO:0090161 IMP
Subcellular Localization
    Golgi apparatus GO:0005794 ISS
    microtubule GO:0005874 IDA
    cytoplasmic microtubule GO:0005881 ISS
    actin filament GO:0005884 IBA
    cilium GO:0005929 IDA
 Experiment description of studies that identified FHDC1 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for FHDC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST3H3 8290
Cross-Linking-MS (XL-MS) Homo sapiens
2 RBCK1  
Affinity Capture-MS Homo sapiens
3 BCCIP 56647
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which FHDC1 is involved
No pathways found





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