Gene description for DCHS1
Gene name dachsous cadherin-related 1
Gene symbol DCHS1
Other names/aliases CDH19
CDH25
CDHR6
FIB1
PCDH16
VMLDS1
Species Homo sapiens
 Database cross references - DCHS1
ExoCarta ExoCarta_8642
Vesiclepedia VP_8642
Entrez Gene 8642
HGNC 13681
MIM 603057
UniProt Q96JQ0  
 DCHS1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for DCHS1
Molecular Function
    calcium ion binding GO:0005509 IEA
    beta-catenin binding GO:0008013 IBA
    cadherin binding GO:0045296 IBA
Biological Process
    branching involved in ureteric bud morphogenesis GO:0001658 IEA
    mitral valve formation GO:0003192 IMP
    cell migration involved in endocardial cushion formation GO:0003273 IMP
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISS
    pattern specification process GO:0007389 IEA
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 NAS
    cell migration GO:0016477 IBA
    neural tube development GO:0021915 IEA
    neurogenesis GO:0022008 ISS
    hippo signaling GO:0035329 ISS
    post-anal tail morphogenesis GO:0036342 IEA
    ossification involved in bone maturation GO:0043931 IEA
    digestive tract development GO:0048565 IEA
    condensed mesenchymal cell proliferation GO:0072137 IEA
    protein localization to plasma membrane GO:0072659 IEA
    cochlea development GO:0090102 IEA
    cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 IBA
Subcellular Localization
    membrane GO:0016020 NAS
    catenin complex GO:0016342 IBA
    apical part of cell GO:0045177 IEA
 Experiment description of studies that identified DCHS1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DCHS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PCDHGA6 56109
Affinity Capture-MS Homo sapiens
2 C7orf34  
Affinity Capture-MS Homo sapiens
3 LIX1L 128077
Affinity Capture-MS Homo sapiens
4 NUP210P1  
Affinity Capture-MS Homo sapiens
5 DCANP1  
Affinity Capture-MS Homo sapiens
6 CDH16  
Affinity Capture-MS Homo sapiens
7 RYK 6259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PCDHGB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SPSB4  
Affinity Capture-MS Homo sapiens
10 PCDHGA7 56108
Affinity Capture-MS Homo sapiens
11 PPIAL4G  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 LOC254896  
Affinity Capture-MS Homo sapiens
13 DYRK1A 1859
Affinity Capture-MS Homo sapiens
14 B4GALT2  
Affinity Capture-MS Homo sapiens
15 XAGE1B  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DCHS1 is involved
No pathways found





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