Gene description for DUOXA1
Gene name dual oxidase maturation factor 1
Gene symbol DUOXA1
Other names/aliases NIP
NUMBIP
mol
Species Homo sapiens
 Database cross references - DUOXA1
ExoCarta ExoCarta_90527
Vesiclepedia VP_90527
Entrez Gene 90527
HGNC 26507
MIM 612771
UniProt Q1HG43  
 DUOXA1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for DUOXA1
Molecular Function
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
Biological Process
    protein localization GO:0008104 IGI
    positive regulation of hydrogen peroxide biosynthetic process GO:0010729 IMP
    protein transport GO:0015031 IEA
    hydrogen peroxide metabolic process GO:0042743 IEA
    positive regulation of neuron differentiation GO:0045666 IEA
    regulation of inflammatory response GO:0050727 IEA
    regulation of thyroid hormone generation GO:2000609 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 IBA
    cell leading edge GO:0031252 IGI
 Experiment description of studies that identified DUOXA1 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DUOXA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSMD14 10213
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DUOXA1 is involved
No pathways found





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