Gene description for BMP15
Gene name bone morphogenetic protein 15
Gene symbol BMP15
Other names/aliases GDF9B
ODG2
POF4
Species Homo sapiens
 Database cross references - BMP15
ExoCarta ExoCarta_9210
Vesiclepedia VP_9210
Entrez Gene 9210
HGNC 1068
MIM 300247
UniProt O95972  
 BMP15 identified in sEVs derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for BMP15
Molecular Function
    cytokine activity GO:0005125 IBA
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
Biological Process
    signal transduction GO:0007165 IEA
    female gamete generation GO:0007292 TAS
Subcellular Localization
    extracellular space GO:0005615 IBA
    endoplasmic reticulum lumen GO:0005788 TAS
 Experiment description of studies that identified BMP15 in sEVs
1
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BMP15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DCAF6 55827
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 AMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
4 HECTD1 25831
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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