Gene description for CACNA2D2
Gene name calcium channel, voltage-dependent, alpha 2/delta subunit 2
Gene symbol CACNA2D2
Other names/aliases CACNA2D
Species Homo sapiens
 Database cross references - CACNA2D2
ExoCarta ExoCarta_9254
Vesiclepedia VP_9254
Entrez Gene 9254
HGNC 1400
MIM 607082
UniProt Q9NY47  
 CACNA2D2 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Prostate cancer cells 25844599    
 Gene ontology annotations for CACNA2D2
Molecular Function
    voltage-gated calcium channel activity GO:0005245 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    neuromuscular junction development GO:0007528 IEA
    organ growth GO:0035265 IEA
    regulation of multicellular organism growth GO:0040014 IEA
    positive regulation of organ growth GO:0046622 IEA
    muscle cell development GO:0055001 IEA
    rhythmic synaptic transmission GO:0060024 IEA
    calcium ion transmembrane transport GO:0070588 IEA
    regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    voltage-gated calcium channel complex GO:0005891 IBA
    presynaptic active zone membrane GO:0048787 IEA
    GABA-ergic synapse GO:0098982 IEA
 Experiment description of studies that identified CACNA2D2 in sEVs
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for CACNA2D2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 LYZL2  
Affinity Capture-MS Homo sapiens
3 UPK2 7379
Affinity Capture-MS Homo sapiens
4 C7orf34  
Affinity Capture-MS Homo sapiens
5 USP2  
Affinity Capture-Western Homo sapiens
6 C7orf69  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 BTNL2  
Affinity Capture-MS Homo sapiens
8 TMEM106A  
Affinity Capture-MS Homo sapiens
9 SLURP1  
Affinity Capture-MS Homo sapiens
10 CLGN 1047
Affinity Capture-MS Homo sapiens
11 DEFB110  
Affinity Capture-MS Homo sapiens
12 DEFA1 1667
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SCGB1D1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 NDP  
Affinity Capture-MS Homo sapiens
15 DEFB109P1B  
Affinity Capture-MS Homo sapiens
16 TAZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TMEM25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 RNASE13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 CBLN4  
Affinity Capture-MS Homo sapiens
20 TRGV3  
Affinity Capture-MS Homo sapiens
21 PDGFRA 5156
Affinity Capture-MS Homo sapiens
22 PRG2  
Affinity Capture-MS Homo sapiens
23 MFAP4 4239
Affinity Capture-MS Homo sapiens
24 PNLIPRP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 RLN1  
Affinity Capture-MS Homo sapiens
26 FUT8 2530
Affinity Capture-MS Homo sapiens
27 LOC254896  
Affinity Capture-MS Homo sapiens
28 B3GALT4  
Affinity Capture-MS Homo sapiens
29 PLA2G5  
Affinity Capture-MS Homo sapiens
30 B3GAT2  
Affinity Capture-MS Homo sapiens
31 NCR3  
Affinity Capture-MS Homo sapiens
32 IFNE  
Affinity Capture-MS Homo sapiens
33 INSL5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 HLA-DPB1 3115
Affinity Capture-MS Homo sapiens
35 SFTPC  
Affinity Capture-MS Homo sapiens
36 EDDM3A  
Affinity Capture-MS Homo sapiens
37 CTSG 1511
Affinity Capture-MS Homo sapiens
38 PATE2  
Affinity Capture-MS Homo sapiens
39 LYZL1  
Affinity Capture-MS Homo sapiens
40 DEFB107A  
Affinity Capture-MS Homo sapiens
41 SCGB1D4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 SIRPD  
Affinity Capture-MS Homo sapiens
43 BRICD5  
Affinity Capture-MS Homo sapiens
44 SDF2L1 23753
Affinity Capture-MS Homo sapiens
45 FAM150B  
Affinity Capture-MS Homo sapiens
46 FBXO2 26232
Affinity Capture-MS Homo sapiens
47 PSCA 8000
Affinity Capture-MS Homo sapiens
48 DEFB135  
Affinity Capture-MS Homo sapiens
49 DEFB123  
Affinity Capture-MS Homo sapiens
50 PON2 5445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 PTPRK 5796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 CD160  
Affinity Capture-MS Homo sapiens
53 HYOU1 10525
Affinity Capture-MS Homo sapiens
54 DHFRL1  
Affinity Capture-MS Homo sapiens
55 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
56 PATE1  
Affinity Capture-MS Homo sapiens
57 BAGE2  
Affinity Capture-MS Homo sapiens
58 ISLR 3671
Affinity Capture-MS Homo sapiens
59 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
60 PTCH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 CANX 821
Affinity Capture-MS Homo sapiens
62 FIBIN  
Affinity Capture-MS Homo sapiens
63 BTNL8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 EDDM3B  
Affinity Capture-MS Homo sapiens
65 FAM69A 388650
Affinity Capture-MS Homo sapiens
66 APOM 55937
Affinity Capture-MS Homo sapiens
67 NMS  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here