Gene description for Csnk1a1
Gene name casein kinase 1, alpha 1
Gene symbol Csnk1a1
Other names/aliases 2610208K14Rik
4632404G05Rik
5430427P18Rik
CK1a
Csnk1a
Species Mus musculus
 Database cross references - Csnk1a1
ExoCarta ExoCarta_93687
Vesiclepedia VP_93687
Entrez Gene 93687
UniProt Q8BK63  
 Csnk1a1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Csnk1a1
Molecular Function
    magnesium ion binding GO:0000287 ISO
    protein kinase activity GO:0004672 IDA
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 ISO
    protein serine/threonine kinase activity GO:0004674 ISS
    protein serine/threonine kinase activity GO:0004674 TAS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    ATP binding GO:0005524 IEA
    ATP binding GO:0005524 ISO
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    peptide binding GO:0042277 ISO
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    phosphoprotein binding GO:0051219 ISO
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    cell morphogenesis GO:0000902 IGI
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IDA
    protein phosphorylation GO:0006468 ISO
    Golgi organization GO:0007030 ISO
    Golgi organization GO:0007030 ISS
    signal transduction GO:0007165 IBA
    Wnt signaling pathway GO:0016055 IEA
    peptidyl-serine phosphorylation GO:0018105 ISO
    peptidyl-serine phosphorylation GO:0018105 ISS
    cellular response to nutrient GO:0031670 ISO
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISO
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 ISS
    positive regulation of Rho protein signal transduction GO:0035025 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 NAS
    intermediate filament cytoskeleton organization GO:0045104 ISO
    intermediate filament cytoskeleton organization GO:0045104 ISS
    cell division GO:0051301 IEA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IBA
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISO
    negative regulation of NLRP3 inflammasome complex assembly GO:1900226 IDA
    positive regulation of TORC1 signaling GO:1904263 ISO
Subcellular Localization
    kinetochore GO:0000776 IEA
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    centrosome GO:0005813 IEA
    centrosome GO:0005813 ISO
    spindle GO:0005819 IDA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 TAS
    mRNA cleavage and polyadenylation specificity factor complex GO:0005847 ISO
    mRNA cleavage and polyadenylation specificity factor complex GO:0005847 ISS
    cilium GO:0005929 TAS
    nuclear speck GO:0016607 ISO
    nuclear speck GO:0016607 ISS
    beta-catenin destruction complex GO:0030877 ISO
    beta-catenin destruction complex GO:0030877 ISS
    beta-catenin destruction complex GO:0030877 NAS
    ciliary basal body GO:0036064 IDA
    keratin filament GO:0045095 ISO
    keratin filament GO:0045095 ISS
    ribonucleoprotein complex GO:1990904 IDA
 Experiment description of studies that identified Csnk1a1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Csnk1a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TGFBR1 7046
Affinity Capture-Luminescence Homo sapiens
2 Tmem173  
Proximity Label-MS Mus musculus
3 SNCA 6622
Affinity Capture-MS Homo sapiens
4 Rpa1 68275
Co-fractionation Mus musculus
5 Kctd13  
Affinity Capture-MS Mus musculus
6 Mycbp2 105689
Affinity Capture-MS Mus musculus
7 Cops2 12848
Biochemical Activity Mus musculus
8 Atg16l1  
Affinity Capture-MS Mus musculus
9 Snapin  
Two-hybrid Mus musculus
10 Nanog  
Affinity Capture-MS Mus musculus
11 Mdm4  
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Csnk1a1 is involved
No pathways found





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