Gene description for CRIPT
Gene name cysteine-rich PDZ-binding protein
Gene symbol CRIPT
Other names/aliases HSPC139
SSMDF
Species Homo sapiens
 Database cross references - CRIPT
ExoCarta ExoCarta_9419
Vesiclepedia VP_9419
Entrez Gene 9419
HGNC 14312
MIM 604594
UniProt Q9P021  
 CRIPT identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CRIPT
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IBA
    microtubule binding GO:0008017 ISS
    PDZ domain binding GO:0030165 IDA
    protein-containing complex binding GO:0044877 ISS
    scaffold protein binding GO:0097110 IDA
Biological Process
    mRNA processing GO:0006397 IEA
    RNA splicing GO:0008380 IEA
    cytoplasmic microtubule organization GO:0031122 IBA
    cytoplasmic microtubule organization GO:0031122 ISS
    protein localization to microtubule GO:0035372 ISS
    establishment of protein localization GO:0045184 ISS
    regulation of postsynaptic density assembly GO:0099151 IEA
    regulation of postsynaptic density protein 95 clustering GO:1902897 ISS
Subcellular Localization
    spliceosomal complex GO:0005681 IEA
    cytoplasm GO:0005737 IEA
    postsynaptic density GO:0014069 ISS
    dendrite GO:0030425 IBA
    dendrite GO:0030425 ISS
    neuronal cell body GO:0043025 ISS
    dendritic spine GO:0043197 ISS
    dendritic shaft GO:0043198 ISS
    glutamatergic synapse GO:0098978 IEA
    postsynaptic density, intracellular component GO:0099092 IEA
 Experiment description of studies that identified CRIPT in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CRIPT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCNA2 890
Affinity Capture-MS Homo sapiens
2 C1orf123 54987
Co-fractionation Homo sapiens
3 Tuba3a 22144
Affinity Capture-MS Mus musculus
4 APEX1 328
Affinity Capture-RNA Homo sapiens
5 ATG16L1 55054
Affinity Capture-MS Homo sapiens
6 THOC2 57187
Affinity Capture-MS Homo sapiens
7 MYCN  
Affinity Capture-MS Homo sapiens
8 Pip4k2c  
Affinity Capture-MS Mus musculus
9 UBQLN4 56893
Two-hybrid Homo sapiens
10 MECP2 4204
Affinity Capture-MS Homo sapiens
11 CEP170P1  
Affinity Capture-MS Homo sapiens
12 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
13 CUL3 8452
Affinity Capture-MS Homo sapiens
14 CEBPA  
Protein-peptide Homo sapiens
15 DLG4  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
16 NLRP2  
Affinity Capture-MS Homo sapiens
17 MORC3 23515
Affinity Capture-MS Homo sapiens
18 DLG3 1741
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
19 Zbtb48  
Affinity Capture-MS Mus musculus
20 DLG1 1739
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which CRIPT is involved
No pathways found





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