Gene description for GMFG
Gene name glia maturation factor, gamma
Gene symbol GMFG
Other names/aliases GMF-GAMMA
Species Homo sapiens
 Database cross references - GMFG
ExoCarta ExoCarta_9535
Vesiclepedia VP_9535
Entrez Gene 9535
HGNC 4374
MIM 604104
UniProt O60234  
 GMFG identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for GMFG
Molecular Function
    actin binding GO:0003779 IEA
    protein kinase inhibitor activity GO:0004860 TAS
    enzyme activator activity GO:0008047 TAS
    growth factor activity GO:0008083 IEA
    Arp2/3 complex binding GO:0071933 IBA
Biological Process
    protein phosphorylation GO:0006468 TAS
    signal transduction GO:0007165 IEA
    negative regulation of Arp2/3 complex-mediated actin nucleation GO:0034316 IBA
    actin filament debranching GO:0071846 IBA
Subcellular Localization
    extracellular region GO:0005576 TAS
    cortical actin cytoskeleton GO:0030864 IBA
    secretory granule lumen GO:0034774 TAS
    ficolin-1-rich granule lumen GO:1904813 TAS
 Experiment description of studies that identified GMFG in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GMFG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CAMK1D 57118
Two-hybrid Homo sapiens
2 CLSTN1 22883
Affinity Capture-MS Homo sapiens
3 FN3K 64122
Affinity Capture-MS Homo sapiens
4 VAT1 10493
Affinity Capture-MS Homo sapiens
5 GMFB 2764
Affinity Capture-MS Homo sapiens
6 HSPA14 51182
Affinity Capture-MS Homo sapiens
7 KLK10 5655
Affinity Capture-MS Homo sapiens
8 CEBPA  
Protein-peptide Homo sapiens
9 LANCL2 55915
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PRUNE 58497
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 VANGL1 81839
Two-hybrid Homo sapiens
12 U2AF2 11338
Affinity Capture-MS Homo sapiens
13 SPATA8  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GMFG is involved
PathwayEvidenceSource
Immune System TAS Reactome
Innate Immune System TAS Reactome
Neutrophil degranulation TAS Reactome





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