Exosome protein, RNA and lipid database
Exosomes are 40-100 nm membrane vesicles of endocytic origin secreted by most cell types in vitro. ExoCarta, an exosome database, provides with the contents that were identified in exosomes in multiple organisms.
Extracellular Microvesicles: The Need for Internationally Recognised Nomenclature and Stringent Purification Criteria
Extracellular microvesicles (eMVs) are a class of membrane bound organelles secreted by various cell types. eMVs include (i) exosomes: 40-100 nm diameter membraneous vesicles of endocytic origin (ii) ectosomes (also referred to as shedding microvesicles, SMVs): large membranous vesicles (50-1000 nm diameter) that are shed directly from the plasma membrane (PM) and (iii) apoptotic blebs (50-5000 nm diameter): released by dying cells. Over the last five years, the field of eMVs has witnessed tremendous growth (more than 3,500 research articles published) mainly due to their purported role in intercellular signaling and possible source of disease biomarkers. Whilst these studies have advanced our understanding of eMVs, two key problems persist that require immediate attention.
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|External links of interest to the extracellular vesicle researchers|
|Journal of Extracellular Vesicles|
|International Society for Extracellular Vesicles
|Want to contribute to ExoCarta?|
We will keep ExoCarta updated with new exosome studies. We would love to have scientific community participation in any of the following ways.
Send unpublished exosome proteome/RNA/lipid datasets (it can be made private until published)
Point out an exosome publication that we missed
Contact us either to upload your exosome data or point to us if we have not added any published exosome study.
|Simpson, R.J., Kalra, H. and Mathivanan, S. ExoCarta as a resource for exosomal research Journal of Extracellular Vesicles. 2012. PubMed|
|Mathivanan, S. Fahner, C.J., Reid, G.E., and Simpson, R.J. ExoCarta 2012: database of exosomal proteins, RNA and lipids. Nucleic Acids Research. 2012. PubMed|
|Mathivanan, S. and Simpson, R.J. ExoCarta: A compendium of exosomal proteins and RNA. Proteomics. 2009. 21, 4997-5000. PubMed|
1. Simpson RJ and Mathivanan S. Extracellular Microvesicles: The Need for Internationally Recognised Nomenclature and Stringent Purification Criteria J Proteomics Bioinform. 2012. PubMed|
2. Théry C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009. 8, 581-93. PubMed
3. Keller S, Sanderson MP, Stoeck A, Altevogt P. Exosomes: from biogenesis and secretion to biological function. Immunol Lett. 2006. 2, 102-8. PubMed
4. Simpson RJ, Lim JW, Moritz RL, Mathivanan S. Exosomes: proteomic insights and diagnostic potential. Expert Rev Proteomics. 2009. 3, 267-83. PubMed
5. Record M, Subra C, Silvente-Poirot S, Poirot M. Exosomes as intercellular signalosomes and pharmacological effectors. Biochem Pharmacol. 2011.10, 1171-82. PubMed
6. Cocucci E, Racchetti G, Meldolesi J. Shedding microvesicles: artefacts no more. Trends Cell Biol. 2009. 2, 43-51. PubMed
7. Schorey JS, Bhatnagar S. Exosome function: from tumor immunology to pathogen biology. Traffic. 2008. 6, 871-81. PubMed
8. Mathivanan S, Ji H, Simpson RJ. Exosomes: Extracellular organelles important in intercellular communication. Journal of Proteomics. 2010. PubMed
9. van Niel G, Porto-Carreiro I, Simoes S, Raposo G. Exosomes: a common pathway for a specialized function. J Biochem. 2006. 1, 13-21. PubMed
10. Johnstone RM. Exosomes biological significance: A concise review. Blood Cells Mol Dis. 2006. 2, 315-21. PubMed
More exosome articles .....