Gene description for SNUPN
Gene name snurportin 1
Gene symbol SNUPN
Other names/aliases KPNBL
RNUT1
Snurportin1
Species Homo sapiens
 Database cross references - SNUPN
ExoCarta ExoCarta_10073
Vesiclepedia VP_10073
Entrez Gene 10073
HGNC 14245
MIM 607902
UniProt O95149  
 SNUPN identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SNUPN
Molecular Function
    RNA cap binding GO:0000339 TAS
    protein binding GO:0005515 IPI
    nuclear import signal receptor activity GO:0061608 IEA
Biological Process
    RNA import into nucleus GO:0006404 IDA
    RNA import into nucleus GO:0006404 IMP
    protein import into nucleus GO:0006606 IEA
    cytoskeleton organization GO:0007010 IMP
    protein complex oligomerization GO:0051259 IMP
    protein tetramerization GO:0051262 IMP
    snRNA import into nucleus GO:0061015 IEA
Subcellular Localization
    nucleus GO:0005634 IMP
    nuclear pore GO:0005643 TAS
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 NAS
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    NLS-dependent protein nuclear import complex GO:0042564 IPI
 Experiment description of studies that identified SNUPN in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SNUPN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNRPB2 6629
Affinity Capture-MS Homo sapiens
2 GCNT3 9245
Two-hybrid Homo sapiens
3 YEATS4  
Affinity Capture-MS Homo sapiens
4 MTHFD2 10797
Co-fractionation Homo sapiens
5 Tor1aip1  
Affinity Capture-MS Mus musculus
6 RNF126  
Two-hybrid Homo sapiens
7 HSPA2 3306
Affinity Capture-MS Homo sapiens
8 SNRPG 6637
Affinity Capture-MS Homo sapiens
9 TOE1 114034
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 SMN1 6606
Reconstituted Complex Homo sapiens
11 SNRPE 6635
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 XPO1 7514
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
13 USP15 9958
Affinity Capture-MS Homo sapiens
14 Dync1li1 235661
Affinity Capture-MS Mus musculus
15 SNRPB 6628
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
16 ZPR1 8882
Reconstituted Complex Homo sapiens
17 KPNB1 3837
Reconstituted Complex Homo sapiens
18 DBN1 1627
Two-hybrid Homo sapiens
19 EGFR 1956
Negative Genetic Homo sapiens
20 EGLN1 54583
Affinity Capture-MS Homo sapiens
21 SNRPF 6636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 GNAI1 2770
Affinity Capture-MS Homo sapiens
23 RNPC3  
Affinity Capture-MS Homo sapiens
24 DDX20 11218
Reconstituted Complex Homo sapiens
25 MEX3B 84206
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
26 SNRPD1 6632
Affinity Capture-MS Homo sapiens
27 PPP1R8 5511
Co-fractionation Homo sapiens
28 HOTAIR  
Affinity Capture-RNA Homo sapiens
29 SNRPN 6638
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 ENO2 2026
Two-hybrid Homo sapiens
31 PEX5 5830
Two-hybrid Homo sapiens
32 SNW1 22938
Affinity Capture-MS Homo sapiens
33 KRAS 3845
Negative Genetic Homo sapiens
34 FCRLA 84824
Affinity Capture-MS Homo sapiens
35 SNRPA1 6627
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 PDP1 54704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 TNNT3  
Two-hybrid Homo sapiens
38 SLC33A1 9197
Affinity Capture-MS Homo sapiens
39 XRCC5 7520
Affinity Capture-MS Homo sapiens
40 SNRPD3 6634
Affinity Capture-MS Homo sapiens
41 RAN 5901
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which SNUPN is involved
PathwayEvidenceSource
Metabolism of non-coding RNA TAS Reactome
Metabolism of RNA TAS Reactome
snRNP Assembly TAS Reactome





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