Gene description for MRVI1
Gene name murine retrovirus integration site 1 homolog
Gene symbol MRVI1
Other names/aliases IRAG
JAW1L
Species Homo sapiens
 Database cross references - MRVI1
ExoCarta ExoCarta_10335
Vesiclepedia VP_10335
Entrez Gene 10335
HGNC 7237
MIM 604673
UniProt Q9Y6F6  
 MRVI1 identified in sEVs derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for MRVI1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cGMP-mediated signaling GO:0019934 IBA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    sarcoplasmic reticulum GO:0016529 IEA
    platelet dense tubular network membrane GO:0031095 TAS
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified MRVI1 in sEVs
1
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MRVI1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITPR1 3708
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
2 MME 4311
Affinity Capture-MS Homo sapiens
3 BOK  
Affinity Capture-MS Homo sapiens
4 RDX 5962
Affinity Capture-MS Homo sapiens
5 ITPR2 3709
Affinity Capture-MS Homo sapiens
6 USP25  
Affinity Capture-MS Homo sapiens
7 ITPR3 3710
Affinity Capture-MS Homo sapiens
8 SSFA2 6744
Affinity Capture-MS Homo sapiens
9 FRMD5 84978
Affinity Capture-MS Homo sapiens
10 PRKG1 5592
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
11 CDK5RAP3 80279
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MRVI1 is involved
PathwayEvidenceSource
cGMP effects TAS Reactome
Hemostasis TAS Reactome
Nitric oxide stimulates guanylate cyclase TAS Reactome
Platelet homeostasis TAS Reactome





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