Gene description for Baiap2
Gene name brain-specific angiogenesis inhibitor 1-associated protein 2
Gene symbol Baiap2
Other names/aliases IRSp53
R75030
Species Mus musculus
 Database cross references - Baiap2
ExoCarta ExoCarta_108100
Vesiclepedia VP_108100
Entrez Gene 108100
UniProt Q8BKX1  
 Baiap2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Baiap2
Molecular Function
    transcription coregulator binding GO:0001221 IEA
    transcription coregulator binding GO:0001221 ISO
    protein binding GO:0005515 IPI
    cytoskeletal anchor activity GO:0008093 IEA
    PDZ domain binding GO:0030165 IEA
    PDZ domain binding GO:0030165 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    proline-rich region binding GO:0070064 ISO
    proline-rich region binding GO:0070064 ISS
    scaffold protein binding GO:0097110 IEA
    scaffold protein binding GO:0097110 ISO
Biological Process
    plasma membrane organization GO:0007009 IEA
    Rho protein signal transduction GO:0007266 TAS
    regulation of cell shape GO:0008360 IMP
    positive regulation of neuron projection development GO:0010976 ISO
    dendrite development GO:0016358 IMP
    positive regulation of actin filament polymerization GO:0030838 IBA
    regulation of actin cytoskeleton organization GO:0032956 ISO
    regulation of actin cytoskeleton organization GO:0032956 ISS
    protein localization to synapse GO:0035418 IEA
    protein localization to synapse GO:0035418 ISO
    regulation of synaptic plasticity GO:0048167 IMP
    modulation of chemical synaptic transmission GO:0050804 IDA
    modulation of chemical synaptic transmission GO:0050804 IMP
    actin filament bundle assembly GO:0051017 IBA
    actin filament bundle assembly GO:0051017 IGI
    actin filament bundle assembly GO:0051017 IMP
    actin crosslink formation GO:0051764 IBA
    actin crosslink formation GO:0051764 IMP
    positive regulation of dendritic spine morphogenesis GO:0061003 IEA
    positive regulation of dendritic spine morphogenesis GO:0061003 ISO
    cellular response to epidermal growth factor stimulus GO:0071364 IEA
    regulation of postsynapse organization GO:0099175 ISO
    cellular response to L-glutamate GO:1905232 IEA
    regulation of modification of postsynaptic actin cytoskeleton GO:1905274 IEA
    regulation of modification of postsynaptic actin cytoskeleton GO:1905274 ISO
    positive regulation of excitatory postsynaptic potential GO:2000463 IEA
    positive regulation of excitatory postsynaptic potential GO:2000463 ISO
Subcellular Localization
    ruffle GO:0001726 IEA
    nucleoplasm GO:0005654 IBA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    microtubule GO:0005874 IEA
    microtubule GO:0005874 ISO
    plasma membrane GO:0005886 ISO
    actin cytoskeleton GO:0015629 ISO
    actin cytoskeleton GO:0015629 ISS
    lamellipodium GO:0030027 IEA
    lamellipodium GO:0030027 ISO
    secretory granule GO:0030141 IEA
    secretory granule GO:0030141 ISO
    filopodium GO:0030175 IEA
    neuron projection GO:0043005 IDA
    neuronal cell body GO:0043025 IEA
    neuronal cell body GO:0043025 ISO
    dendritic spine GO:0043197 ISO
    dendritic shaft GO:0043198 IEA
    dendritic shaft GO:0043198 ISO
    neuron projection terminus GO:0044306 IEA
    neuron projection terminus GO:0044306 ISO
    excitatory synapse GO:0060076 IEA
    excitatory synapse GO:0060076 ISO
    neuron projection branch point GO:0061845 IEA
    neuron projection branch point GO:0061845 ISO
    dendritic spine cytoplasm GO:0061846 IEA
    dendritic spine cytoplasm GO:0061846 ISO
    synaptic membrane GO:0097060 IEA
    synaptic membrane GO:0097060 ISO
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IMP
    presynapse GO:0098793 ISO
    postsynapse GO:0098794 ISO
    glutamatergic synapse GO:0098978 IEA
    glutamatergic synapse GO:0098978 ISO
    postsynaptic density, intracellular component GO:0099092 IEA
    postsynaptic density, intracellular component GO:0099092 ISO
    presynaptic cytosol GO:0099523 IEA
    presynaptic cytosol GO:0099523 ISO
    postsynaptic cytosol GO:0099524 IEA
    postsynaptic cytosol GO:0099524 ISO
 Experiment description of studies that identified Baiap2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Baiap2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nckap1 50884
Affinity Capture-MS Mus musculus
2 Fxr1 14359
Affinity Capture-MS Mus musculus
3 Syngap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
4 Cnksr2  
Affinity Capture-MS Mus musculus
5 Cyfip1 20430
Affinity Capture-MS Mus musculus
6 Kctd13  
Affinity Capture-MS Mus musculus
7 Dlg4  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
8 Tnik  
Affinity Capture-MS Mus musculus
9 Shank3  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
10 Inadl  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
11 Ywhae 22627
Affinity Capture-MS Mus musculus
12 Dlgap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
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