Gene description for FTCD
Gene name formimidoyltransferase cyclodeaminase
Gene symbol FTCD
Other names/aliases LCHC1
Species Homo sapiens
 Database cross references - FTCD
ExoCarta ExoCarta_10841
Vesiclepedia VP_10841
Entrez Gene 10841
HGNC 3974
MIM 606806
UniProt O95954  
 FTCD identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for FTCD
Molecular Function
    protein binding GO:0005515 IPI
    folic acid binding GO:0005542 IEA
    microtubule binding GO:0008017 IDA
    microtubule binding GO:0008017 ISS
    glutamate formimidoyltransferase activity GO:0030409 IDA
    glutamate formimidoyltransferase activity GO:0030409 ISS
    formimidoyltetrahydrofolate cyclodeaminase activity GO:0030412 ISS
Biological Process
    folic acid-containing compound metabolic process GO:0006760 TAS
    cytoskeleton organization GO:0007010 IEA
    L-histidine catabolic process to glutamate and formamide GO:0019556 IEA
    L-histidine catabolic process to glutamate and formate GO:0019557 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    Golgi membrane GO:0000139 ISS
    cytoplasm GO:0005737 TAS
    endoplasmic reticulum GO:0005783 ISS
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 ISS
    Golgi apparatus GO:0005794 ISS
    centriole GO:0005814 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    smooth endoplasmic reticulum membrane GO:0030868 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified FTCD in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for FTCD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCDC183  
Two-hybrid Homo sapiens
2 GRB14 2888
Co-fractionation Homo sapiens
3 HGS 9146
Two-hybrid Homo sapiens
4 TNKS2 80351
Co-fractionation Homo sapiens
5 CCDC155  
Two-hybrid Homo sapiens
6 MED4 29079
Two-hybrid Homo sapiens
7 HIF1A 3091
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which FTCD is involved
PathwayEvidenceSource
Histidine catabolism TAS Reactome
Metabolism TAS Reactome
Metabolism of amino acids and derivatives TAS Reactome





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