Gene description for PTPN21
Gene name protein tyrosine phosphatase, non-receptor type 21
Gene symbol PTPN21
Other names/aliases PTPD1
PTPRL10
Species Homo sapiens
 Database cross references - PTPN21
ExoCarta ExoCarta_11099
Vesiclepedia VP_11099
Entrez Gene 11099
HGNC 9651
MIM 603271
UniProt Q16825  
 PTPN21 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PTPN21
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IBA
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    protein binding GO:0005515 IPI
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    protein dephosphorylation GO:0006470 TAS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified PTPN21 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PTPN21
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DUSP7  
Affinity Capture-MS Homo sapiens
2 RSL1D1 26156
Cross-Linking-MS (XL-MS) Homo sapiens
3 ACAD8 27034
Affinity Capture-MS Homo sapiens
4 TRIP6 7205
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 PFDN6 10471
Affinity Capture-MS Homo sapiens
6 TTC26 79989
Affinity Capture-MS Homo sapiens
7 TMX3 54495
Affinity Capture-MS Homo sapiens
8 AHCYL1 10768
Affinity Capture-MS Homo sapiens
9 POLR1B 84172
Affinity Capture-MS Homo sapiens
10 WWP1 11059
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 NDUFA9 4704
Affinity Capture-MS Homo sapiens
12 YWHAB 7529
Affinity Capture-MS Homo sapiens
13 YWHAE 7531
Affinity Capture-MS Homo sapiens
14 WWC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 AJUBA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 POLR1C 9533
Affinity Capture-MS Homo sapiens
17 YWHAZ 7534
Affinity Capture-MS Homo sapiens
18 USP9X 8239
Affinity Capture-MS Homo sapiens
19 LPP 4026
Affinity Capture-MS Homo sapiens
20 WDR26 80232
Affinity Capture-MS Homo sapiens
21 NAF1  
Affinity Capture-MS Homo sapiens
22 ELP2 55250
Affinity Capture-MS Homo sapiens
23 PM20D2 135293
Affinity Capture-MS Homo sapiens
24 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
25 VBP1 7411
Affinity Capture-MS Homo sapiens
26 DCAF8 50717
Affinity Capture-MS Homo sapiens
27 NEK7 140609
Affinity Capture-MS Homo sapiens
28 AHCYL2 23382
Affinity Capture-MS Homo sapiens
29 WDR5 11091
Affinity Capture-MS Homo sapiens
30 PTPN21 11099
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 STXBP4 252983
Affinity Capture-MS Homo sapiens
32 YAP1 10413
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
33 CDK4 1019
Affinity Capture-MS Homo sapiens
34 WWC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
35 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
36 IFT52 51098
Affinity Capture-MS Homo sapiens
37 BPIFB1 92747
Affinity Capture-MS Homo sapiens
38 RPL35A 6165
Cross-Linking-MS (XL-MS) Homo sapiens
39 AKR7A2 8574
Affinity Capture-MS Homo sapiens
40 RHPN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 AMOT 154796
Affinity Capture-MS Homo sapiens
42 SRC 6714
Affinity Capture-Western Homo sapiens
43 PFDN4 5203
Affinity Capture-MS Homo sapiens
44 YWHAG 7532
Affinity Capture-MS Homo sapiens
45 KIF1C 10749
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
46 ARMC8 25852
Affinity Capture-MS Homo sapiens
47 BMX  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
48 PARD6B 84612
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 DCAF5  
Affinity Capture-MS Homo sapiens
50 DNAJB11 51726
Affinity Capture-MS Homo sapiens
51 RMND5A 64795
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PTPN21 is involved
No pathways found





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