Experiment description of studies that identified MAL2 in sEVs

1 Experiment ID 274 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81 Enriched markers ✔ AIF Negative markers ✔ NTA Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 25844599     Organism Homo sapiens Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T." Journal name Oncotarget Publication year 2015 Sample Prostate cancer cells Sample name DU145 - Docetaxel resistant Isolation/purification methods Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.13-1.18 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry Flow cytometry Western blotting

2 Experiment ID 191 MISEV standards ✘ Biophysical techniques ✔ Alix|CD81|CD9 Enriched markers ✘ Negative markers ✘ Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 20124223     Organism Homo sapiens Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK." Journal name Mol Cell Proteomics Publication year 2010 Sample Squamous carcinoma cells Sample name Squamous carcinoma cell (A431) Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

3 Experiment ID 63 MISEV standards ✘ Biophysical techniques ✔ AQP2 Enriched markers ✘ Negative markers ✘ Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 19056867     Organism Homo sapiens Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes. Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA" Journal name JASN Publication year 2009 Sample Urine Sample name Urine - Normal Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ] Western blotting

Protein-protein interactions for MAL2

Protein Interactor ExoCarta ID Identification method PubMed Species 1 NFAM1   Two-hybrid Homo sapiens 2 RAB37 326624 Two-hybrid Homo sapiens 3 MRM1   Two-hybrid Homo sapiens 4 ADCK3   Two-hybrid Homo sapiens 5 TUBB 203068 Two-hybrid Homo sapiens 6 SGK1   Two-hybrid Homo sapiens 7 MTERF3   Two-hybrid Homo sapiens 8 CD68 968 Two-hybrid Homo sapiens 9 SH3GL1 6455 Two-hybrid Homo sapiens Two-hybrid Homo sapiens 10 TPD52L1 7164 Two-hybrid Homo sapiens 11 HSFX1   Two-hybrid Homo sapiens 12 PPP1CA 5499 Two-hybrid Homo sapiens 13 ABCG8   Two-hybrid Homo sapiens 14 GAD1   Two-hybrid Homo sapiens 15 GPR152   Two-hybrid Homo sapiens 16 TMEM14B   Two-hybrid Homo sapiens 17 PTPN9 5780 Two-hybrid Homo sapiens 18 HSFX2   Two-hybrid Homo sapiens 19 ELAVL1 1994 Affinity Capture-RNA Homo sapiens 20 REEP4   Two-hybrid Homo sapiens 21 SUCLA2 8803 Two-hybrid Homo sapiens 22 VARS2   Two-hybrid Homo sapiens 23 ARFIP2 23647 Two-hybrid Homo sapiens Two-hybrid Homo sapiens 24 PBX3   Two-hybrid Homo sapiens Two-hybrid Homo sapiens 25 CREB3L1   Two-hybrid Homo sapiens 26 FAM3A 60343 Two-hybrid Homo sapiens 27 GJB1 2705 Two-hybrid Homo sapiens 28 TPD52 7163 Two-hybrid Homo sapiens Reconstituted Complex Homo sapiens 29 ATP6V0E1   Two-hybrid Homo sapiens 30 NDRG4 65009 Two-hybrid Homo sapiens 31 TBRG4 9238 Two-hybrid Homo sapiens 32 THAP4 51078 Two-hybrid Homo sapiens 33 POLL   Two-hybrid Homo sapiens 34 FAM134C 162427 Two-hybrid Homo sapiens 35 CREB3   Two-hybrid Homo sapiens 36 CD160   Two-hybrid Homo sapiens 37 MUC1 4582 Two-hybrid Homo sapiens 38 GAD2   Two-hybrid Homo sapiens Two-hybrid Homo sapiens 39 ATP4A 495 Affinity Capture-MS Homo sapiens 40 KIAA0368 23392 Two-hybrid Homo sapiens 41 ARL13B 200894 Two-hybrid Homo sapiens 42 PITPNC1   Two-hybrid Homo sapiens 43 SCN3B   Two-hybrid Homo sapiens 44 TTPA   Two-hybrid Homo sapiens View the network

Pathways in which MAL2 is involved

No pathways found