Gene description for OSBPL11
Gene name oxysterol binding protein-like 11
Gene symbol OSBPL11
Other names/aliases ORP-11
ORP11
OSBP12
TCCCIA00292
Species Homo sapiens
 Database cross references - OSBPL11
ExoCarta ExoCarta_114885
Vesiclepedia VP_114885
Entrez Gene 114885
HGNC 16397
MIM 606739
UniProt Q9BXB4  
 OSBPL11 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for OSBPL11
Molecular Function
    protein binding GO:0005515 IPI
    sterol binding GO:0032934 IBA
Biological Process
    lipid transport GO:0006869 IEA
    positive regulation of sequestering of triglyceride GO:0010890 IMP
    fat cell differentiation GO:0045444 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IBA
    membrane GO:0016020 IBA
    late endosome membrane GO:0031902 IEA
 Experiment description of studies that identified OSBPL11 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for OSBPL11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 REEP5 7905
Proximity Label-MS Homo sapiens
2 KLHL20  
Affinity Capture-MS Homo sapiens
3 GJD3  
Proximity Label-MS Homo sapiens
4 RAB35 11021
Proximity Label-MS Homo sapiens
5 TPCN2  
Affinity Capture-MS Homo sapiens
6 HSPA2 3306
Affinity Capture-MS Homo sapiens
7 TERF2  
Affinity Capture-MS Homo sapiens
8 VAPA 9218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 PTPN1 5770
Proximity Label-MS Homo sapiens
10 VAPB 9217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 METTL7A 25840
Proximity Label-MS Homo sapiens
12 TP53 7157
Affinity Capture-MS Homo sapiens
13 MARCKS 4082
Proximity Label-MS Homo sapiens
14 FUZ 80199
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 LRRC59 55379
Proximity Label-MS Homo sapiens
16 LAMP3  
Proximity Label-MS Homo sapiens
17 NUP155 9631
Proximity Label-MS Homo sapiens
18 AKT1 207
Biochemical Activity Homo sapiens
19 RAB5A 5868
Proximity Label-MS Homo sapiens
20 LAMP1 3916
Proximity Label-MS Homo sapiens
21 SNAP25 6616
PCA Homo sapiens
22 CFAP36 112942
Affinity Capture-MS Homo sapiens
23 HSD3B7 80270
Proximity Label-MS Homo sapiens
24 SKP2  
Affinity Capture-MS Homo sapiens
25 STIM1 6786
Proximity Label-MS Homo sapiens
26 EMD 2010
Proximity Label-MS Homo sapiens
27 LAMP2 3920
Proximity Label-MS Homo sapiens
28 FKBP8 23770
Proximity Label-MS Homo sapiens
29 CAND1 55832
Affinity Capture-MS Homo sapiens
30 ARF6 382
Proximity Label-MS Homo sapiens
31 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
32 STX4 6810
Proximity Label-MS Homo sapiens
33 KCNE3  
Affinity Capture-MS Homo sapiens
34 APP 351
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
35 DNAJA1 3301
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 RAB4A 5867
Proximity Label-MS Homo sapiens
37 ANAPC2 29882
Proximity Label-MS Homo sapiens
38 LAMTOR1 55004
Proximity Label-MS Homo sapiens
39 PARK2  
Affinity Capture-MS Homo sapiens
40 B3GAT1  
Proximity Label-MS Homo sapiens
41 OSBPL10  
Affinity Capture-MS Homo sapiens
42 RAB2A 5862
Proximity Label-MS Homo sapiens
43 SEC62 7095
Proximity Label-MS Homo sapiens
44 PLVAP 83483
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 NTRK1 4914
Affinity Capture-MS Homo sapiens
46 OSBPL9 114883
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 RAB7A 7879
Proximity Label-MS Homo sapiens
48 RAB11A 8766
Proximity Label-MS Homo sapiens
49 GOLGA1  
Proximity Label-MS Homo sapiens
50 KLHL10  
Affinity Capture-MS Homo sapiens
51 TRIP10 9322
Co-fractionation Homo sapiens
52 RAB3B 5865
Proximity Label-MS Homo sapiens
53 AP1G1 164
Co-fractionation Homo sapiens
54 IFT20 90410
Affinity Capture-MS Homo sapiens
55 KRAS 3845
Proximity Label-MS Homo sapiens
56 RAB5C 5878
Proximity Label-MS Homo sapiens
57 RHOB 388
Proximity Label-MS Homo sapiens
58 WDR44 54521
Co-fractionation Homo sapiens
59 CKAP4 10970
Proximity Label-MS Homo sapiens
60 DUSP16  
Affinity Capture-MS Homo sapiens
61 ALOX5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 RPA3 6119
Proximity Label-MS Homo sapiens
63 ELOVL5 60481
Proximity Label-MS Homo sapiens
64 SEC61B 10952
Proximity Label-MS Homo sapiens
65 STX6 10228
Proximity Label-MS Homo sapiens
66 DERL1 79139
Proximity Label-MS Homo sapiens
67 RAB9A 9367
Proximity Label-MS Homo sapiens
68 MYL4 4635
Affinity Capture-MS Homo sapiens
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