Gene description for Ank3
Gene name ankyrin 3, epithelial
Gene symbol Ank3
Other names/aliases 2900054D09Rik
AI314020
Ank-3
AnkG
Ankyrin-3
Ankyrin-G
Species Mus musculus
 Database cross references - Ank3
ExoCarta ExoCarta_11735
Vesiclepedia VP_11735
Entrez Gene 11735
UniProt G5E8K5  
 Ank3 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ank3
Molecular Function
    structural constituent of cytoskeleton GO:0005200 ISO
    protein binding GO:0005515 IPI
    cytoskeletal protein binding GO:0008092 ISO
    cytoskeletal protein binding GO:0008092 ISS
    spectrin binding GO:0030507 ISO
    spectrin binding GO:0030507 ISS
    protein-macromolecule adaptor activity GO:0030674 ISO
    protein-macromolecule adaptor activity GO:0030674 ISS
    transmembrane transporter binding GO:0044325 IBA
    transmembrane transporter binding GO:0044325 IPI
    transmembrane transporter binding GO:0044325 ISO
    cadherin binding GO:0045296 ISO
    cadherin binding GO:0045296 ISS
    phosphorylation-dependent protein binding GO:0140031 ISO
Biological Process
    mitotic cytokinesis GO:0000281 ISO
    plasma membrane organization GO:0007009 ISO
    signal transduction GO:0007165 IEA
    axonogenesis GO:0007409 IMP
    axon guidance GO:0007411 IBA
    axon guidance GO:0007411 IMP
    neuromuscular junction development GO:0007528 ISS
    anterograde axonal transport GO:0008089 ISO
    positive regulation of gene expression GO:0010628 ISO
    positive regulation of gene expression GO:0010628 ISS
    positive regulation of cell communication by electrical coupling GO:0010650 ISO
    positive regulation of cell communication by electrical coupling GO:0010650 ISS
    positive regulation of sodium ion transport GO:0010765 ISO
    positive regulation of sodium ion transport GO:0010765 ISS
    magnesium ion homeostasis GO:0010960 IMP
    neuronal action potential GO:0019228 IMP
    establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 ISO
    maintenance of protein location in cell GO:0032507 ISO
    positive regulation of homotypic cell-cell adhesion GO:0034112 ISO
    positive regulation of homotypic cell-cell adhesion GO:0034112 ISS
    Golgi to plasma membrane protein transport GO:0043001 ISO
    regulation of potassium ion transport GO:0043266 ISO
    regulation of potassium ion transport GO:0043266 ISS
    clustering of voltage-gated sodium channels GO:0045162 ISO
    establishment of protein localization GO:0045184 ISO
    positive regulation of action potential GO:0045760 TAS
    negative regulation of endocytosis GO:0045806 ISO
    positive regulation of membrane potential GO:0045838 ISO
    positive regulation of membrane potential GO:0045838 ISS
    synapse organization GO:0050808 IBA
    synapse organization GO:0050808 IMP
    axon development GO:0061564 ISO
    cellular response to magnesium ion GO:0071286 IMP
    membrane assembly GO:0071709 ISO
    membrane assembly GO:0071709 ISS
    protein localization to plasma membrane GO:0072659 IBA
    protein localization to plasma membrane GO:0072659 IDA
    protein localization to plasma membrane GO:0072659 IMP
    protein localization to plasma membrane GO:0072659 ISO
    protein localization to plasma membrane GO:0072659 ISS
    maintenance of protein location in plasma membrane GO:0072660 ISO
    positive regulation of protein targeting to membrane GO:0090314 ISO
    positive regulation of protein targeting to membrane GO:0090314 ISS
    protein localization to axon GO:0099612 IMP
    protein localization to axon GO:0099612 ISO
    protein localization to axon GO:0099612 ISS
    positive regulation of membrane depolarization during cardiac muscle cell action potential GO:1900827 ISO
    positive regulation of membrane depolarization during cardiac muscle cell action potential GO:1900827 ISS
    positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 ISO
    negative regulation of delayed rectifier potassium channel activity GO:1902260 IMP
    regulation of protein targeting GO:1903533 ISO
    positive regulation of sodium ion import across plasma membrane GO:1903784 ISO
    positive regulation of sodium ion transmembrane transporter activity GO:2000651 ISS
    positive regulation of cation channel activity GO:2001259 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    lysosome GO:0005764 IEA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    bicellular tight junction GO:0005923 ISO
    basal plasma membrane GO:0009925 ISO
    cell surface GO:0009986 ISO
    cell surface GO:0009986 ISS
    postsynaptic density GO:0014069 IDA
    intercalated disc GO:0014704 IDA
    intercalated disc GO:0014704 ISO
    spectrin-associated cytoskeleton GO:0014731 ISO
    spectrin-associated cytoskeleton GO:0014731 ISS
    membrane GO:0016020 IBA
    membrane GO:0016020 IDA
    basolateral plasma membrane GO:0016323 ISO
    lateral plasma membrane GO:0016328 ISO
    sarcoplasmic reticulum GO:0016529 ISO
    sarcoplasmic reticulum GO:0016529 ISS
    Z disc GO:0030018 ISO
    Z disc GO:0030018 ISS
    T-tubule GO:0030315 ISO
    T-tubule GO:0030315 ISS
    axon GO:0030424 IDA
    axon GO:0030424 ISO
    dendrite GO:0030425 ISO
    dendrite GO:0030425 ISS
    neuromuscular junction GO:0031594 ISO
    neuromuscular junction GO:0031594 ISS
    node of Ranvier GO:0033268 IDA
    node of Ranvier GO:0033268 ISO
    paranode region of axon GO:0033270 IDA
    sarcolemma GO:0042383 ISO
    sarcolemma GO:0042383 ISS
    costamere GO:0043034 ISO
    axon initial segment GO:0043194 IBA
    axon initial segment GO:0043194 IDA
    axon initial segment GO:0043194 IMP
    axon initial segment GO:0043194 ISO
    synapse GO:0045202 IBA
    synapse GO:0045202 IDA
    postsynaptic membrane GO:0045211 ISO
    postsynaptic membrane GO:0045211 ISS
    postsynapse GO:0098794 IDA
 Experiment description of studies that identified Ank3 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ank3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tnik  
Affinity Capture-MS Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Shank3  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
4 Dlg4  
Affinity Capture-MS Mus musculus
5 Agap2  
Affinity Capture-MS Mus musculus
6 Hook1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
7 Acat1 110446
Cross-Linking-MS (XL-MS) Mus musculus
View the network image/svg+xml
 Pathways in which Ank3 is involved
No pathways found





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