Gene description for Apoe
Gene name	apolipoprotein E
Gene symbol	Apoe
Other names/aliases	AI255918 Apo-E
Species	Mus musculus
Database cross references - Apoe
ExoCarta	ExoCarta_11816
Vesiclepedia	VP_11816
Entrez Gene	11816
UniProt	P08226
Apoe identified in sEVs derived from the following tissue/cell type
Mast cells	17486113
Oligodendrocytes	21136642

Gene ontology annotations for Apoe

Molecular Function     amyloid-beta binding GO:0001540 ISO     amyloid-beta binding GO:0001540 ISS     signaling receptor binding GO:0005102 ISO     lipid transporter activity GO:0005319 ISO     protein binding GO:0005515 IPI     phospholipid binding GO:0005543 IBA     phospholipid binding GO:0005543 IEA     phospholipid binding GO:0005543 ISO     heparin binding GO:0008201 ISO     heparin binding GO:0008201 ISS     lipid binding GO:0008289 ISO     antioxidant activity GO:0016209 IEA     antioxidant activity GO:0016209 ISO     enzyme binding GO:0019899 IEA     enzyme binding GO:0019899 ISO     identical protein binding GO:0042802 ISO     identical protein binding GO:0042802 ISS     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     heparan sulfate proteoglycan binding GO:0043395 IDA     heparan sulfate proteoglycan binding GO:0043395 ISO     protein-containing complex binding GO:0044877 ISO     hydroxyapatite binding GO:0046848 ISO     metal chelating activity GO:0046911 IEA     metal chelating activity GO:0046911 ISO     protein dimerization activity GO:0046983 ISO     receptor ligand activity GO:0048018 IEA     tau protein binding GO:0048156 IEA     tau protein binding GO:0048156 ISO     low-density lipoprotein particle receptor binding GO:0050750 ISO     low-density lipoprotein particle receptor binding GO:0050750 ISS     phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 IBA     phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 IMP     phosphatidylcholine-sterol O-acyltransferase activator activity GO:0060228 ISO     very-low-density lipoprotein particle receptor binding GO:0070326 IEA     very-low-density lipoprotein particle receptor binding GO:0070326 ISO     lipoprotein particle binding GO:0071813 IDA     cholesterol transfer activity GO:0120020 IBA     cholesterol transfer activity GO:0120020 IDA Biological Process     negative regulation of endothelial cell proliferation GO:0001937 IEA     negative regulation of endothelial cell proliferation GO:0001937 ISO     response to dietary excess GO:0002021 IMP     lipid metabolic process GO:0006629 IGI     triglyceride metabolic process GO:0006641 IEA     triglyceride metabolic process GO:0006641 ISO     cholesterol catabolic process GO:0006707 IMP     lipid transport GO:0006869 ISO     intracellular calcium ion homeostasis GO:0006874 IDA     receptor-mediated endocytosis GO:0006898 IEA     receptor-mediated endocytosis GO:0006898 ISO     response to oxidative stress GO:0006979 IMP     G protein-coupled receptor signaling pathway GO:0007186 IEA     G protein-coupled receptor signaling pathway GO:0007186 ISO     long-term memory GO:0007616 IEA     long-term memory GO:0007616 ISO     protein localization GO:0008104 IMP     cholesterol metabolic process GO:0008203 IBA     cholesterol metabolic process GO:0008203 IMP     cholesterol metabolic process GO:0008203 ISO     gene expression GO:0010467 IGI     regulation of gene expression GO:0010468 IMP     negative regulation of platelet activation GO:0010544 IEA     negative regulation of platelet activation GO:0010544 ISO     negative regulation of endothelial cell migration GO:0010596 ISO     negative regulation of gene expression GO:0010629 IMP     positive regulation of cholesterol efflux GO:0010875 IMP     positive regulation of cholesterol efflux GO:0010875 ISO     lipid transport involved in lipid storage GO:0010877 IMP     positive regulation of neuron projection development GO:0010976 IMP     positive regulation of neuron projection development GO:0010976 ISO     negative regulation of neuron projection development GO:0010977 IEA     negative regulation of neuron projection development GO:0010977 ISO     long-chain fatty acid transport GO:0015909 IEA     long-chain fatty acid transport GO:0015909 ISO     protein import GO:0017038 ISO     virion assembly GO:0019068 IEA     virion assembly GO:0019068 ISO     negative regulation of blood coagulation GO:0030195 ISO     axon regeneration GO:0031103 IGI     neuron projection development GO:0031175 ISO     melanosome organization GO:0032438 IMP     melanosome organization GO:0032438 ISO     regulation of Cdc42 protein signal transduction GO:0032489 IEA     regulation of Cdc42 protein signal transduction GO:0032489 ISO     positive regulation of low-density lipoprotein particle receptor catabolic process GO:0032805 IEA     positive regulation of low-density lipoprotein particle receptor catabolic process GO:0032805 ISO     cholesterol efflux GO:0033344 IBA     cholesterol efflux GO:0033344 IDA     cholesterol efflux GO:0033344 IMP     cholesterol efflux GO:0033344 ISO     phospholipid efflux GO:0033700 IBA     phospholipid efflux GO:0033700 IEA     phospholipid efflux GO:0033700 ISO     very-low-density lipoprotein particle remodeling GO:0034372 IMP     very-low-density lipoprotein particle remodeling GO:0034372 ISO     low-density lipoprotein particle remodeling GO:0034374 IMP     high-density lipoprotein particle remodeling GO:0034375 IEA     high-density lipoprotein particle remodeling GO:0034375 ISO     high-density lipoprotein particle assembly GO:0034380 ISO     high-density lipoprotein particle assembly GO:0034380 ISS     chylomicron remnant clearance GO:0034382 ISO     chylomicron remnant clearance GO:0034382 ISS     high-density lipoprotein particle clearance GO:0034384 IEA     high-density lipoprotein particle clearance GO:0034384 ISO     very-low-density lipoprotein particle clearance GO:0034447 ISO     very-low-density lipoprotein particle clearance GO:0034447 ISS     locomotory exploration behavior GO:0035641 IEA     locomotory exploration behavior GO:0035641 ISO     nitric oxide-cGMP-mediated signaling GO:0038060 IEA     nitric oxide-cGMP-mediated signaling GO:0038060 ISO     lipoprotein metabolic process GO:0042157 IGI     lipoprotein metabolic process GO:0042157 IMP     lipoprotein metabolic process GO:0042157 ISO     lipoprotein biosynthetic process GO:0042158 IGI     lipoprotein biosynthetic process GO:0042158 ISO     lipoprotein biosynthetic process GO:0042158 ISS     lipoprotein catabolic process GO:0042159 IMP     vasodilation GO:0042311 IMP     cholesterol homeostasis GO:0042632 IGI     cholesterol homeostasis GO:0042632 IMP     cholesterol homeostasis GO:0042632 IMP     cholesterol homeostasis GO:0042632 ISO     regulation of apoptotic process GO:0042981 IMP     amyloid precursor protein metabolic process GO:0042982 IEA     amyloid precursor protein metabolic process GO:0042982 ISO     regulation of protein-containing complex assembly GO:0043254 IEA     regulation of protein-containing complex assembly GO:0043254 ISO     negative regulation of MAP kinase activity GO:0043407 ISO     negative regulation of neuron apoptotic process GO:0043524 ISO     negative regulation of blood vessel endothelial cell migration GO:0043537 IEA     negative regulation of blood vessel endothelial cell migration GO:0043537 ISO     reverse cholesterol transport GO:0043691 IEA     reverse cholesterol transport GO:0043691 ISO     positive regulation by host of viral process GO:0044794 IEA     positive regulation by host of viral process GO:0044794 ISO     regulation of innate immune response GO:0045088 IMP     positive regulation of nitric oxide biosynthetic process GO:0045429 IEA     positive regulation of nitric oxide biosynthetic process GO:0045429 ISO     negative regulation of cholesterol biosynthetic process GO:0045541 IEA     negative regulation of cholesterol biosynthetic process GO:0045541 ISO     positive regulation of axon extension GO:0045773 ISO     positive regulation of endocytosis GO:0045807 IEA     positive regulation of endocytosis GO:0045807 ISO     positive regulation of DNA-templated transcription GO:0045893 IEA     positive regulation of DNA-templated transcription GO:0045893 ISO     positive regulation of lipid biosynthetic process GO:0046889 IEA     positive regulation of lipid biosynthetic process GO:0046889 ISO     negative regulation of smooth muscle cell proliferation GO:0048662 IGI     artery morphogenesis GO:0048844 IGI     negative regulation of protein secretion GO:0050709 IEA     negative regulation of protein secretion GO:0050709 ISO     negative regulation of inflammatory response GO:0050728 IGI     regulation of synapse organization GO:0050807 IDA     regulation of synapse organization GO:0050807 IMP     positive regulation of membrane protein ectodomain proteolysis GO:0051044 IEA     positive regulation of membrane protein ectodomain proteolysis GO:0051044 ISO     negative regulation of lipid biosynthetic process GO:0051055 ISO     regulation of protein metabolic process GO:0051246 ISO     negative regulation of protein metabolic process GO:0051248 ISO     maintenance of location in cell GO:0051651 IMP     lipid homeostasis GO:0055088 IMP     fatty acid homeostasis GO:0055089 IEA     fatty acid homeostasis GO:0055089 ISO     acylglycerol homeostasis GO:0055090 IBA     positive regulation of dendritic spine development GO:0060999 IEA     positive regulation of dendritic spine development GO:0060999 ISO     negative regulation of dendritic spine development GO:0061000 ISO     regulation of proteasomal protein catabolic process GO:0061136 IEA     regulation of proteasomal protein catabolic process GO:0061136 ISO     response to caloric restriction GO:0061771 IEA     response to caloric restriction GO:0061771 ISO     triglyceride homeostasis GO:0070328 IMP     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     cellular response to lipoprotein particle stimulus GO:0071402 IEA     triglyceride-rich lipoprotein particle clearance GO:0071830 IMP     triglyceride-rich lipoprotein particle clearance GO:0071830 ISO     triglyceride-rich lipoprotein particle clearance GO:0071830 ISS     intermediate-density lipoprotein particle clearance GO:0071831 ISO     intermediate-density lipoprotein particle clearance GO:0071831 ISS     circulatory system development GO:0072359 IMP     negative regulation of canonical Wnt signaling pathway GO:0090090 IEA     negative regulation of canonical Wnt signaling pathway GO:0090090 ISO     regulation of cholesterol metabolic process GO:0090181 ISO     positive regulation of cholesterol metabolic process GO:0090205 IMP     positive regulation of cholesterol metabolic process GO:0090205 ISO     regulation of triglyceride metabolic process GO:0090207 ISO     negative regulation of triglyceride metabolic process GO:0090209 IGI     negative regulation of cholesterol efflux GO:0090370 ISO     regulation of plasma lipoprotein particle levels GO:0097006 IMP     AMPA glutamate receptor clustering GO:0097113 ISO     NMDA glutamate receptor clustering GO:0097114 ISO     cellular oxidant detoxification GO:0098869 IEA     positive regulation of lipoprotein transport GO:0140077 IEA     regulation of amyloid-beta clearance GO:1900221 ISO     positive regulation of amyloid-beta clearance GO:1900223 IMP     negative regulation of long-term synaptic potentiation GO:1900272 IEA     negative regulation of long-term synaptic potentiation GO:1900272 ISO     negative regulation of postsynaptic membrane organization GO:1901627 ISO     positive regulation of presynaptic membrane organization GO:1901631 ISO     positive regulation of amyloid-beta formation GO:1902004 ISO     negative regulation of amyloid-beta formation GO:1902430 IEA     negative regulation of amyloid-beta formation GO:1902430 ISO     negative regulation of dendritic spine maintenance GO:1902951 ISO     positive regulation of dendritic spine maintenance GO:1902952 IEA     positive regulation of dendritic spine maintenance GO:1902952 ISO     regulation of amyloid precursor protein catabolic process GO:1902991 ISO     positive regulation of phospholipid efflux GO:1902995 IEA     positive regulation of phospholipid efflux GO:1902995 ISO     positive regulation of neurofibrillary tangle assembly GO:1902998 ISO     negative regulation of phospholipid efflux GO:1902999 ISO     negative regulation of lipid transport across blood-brain barrier GO:1903001 ISO     positive regulation of lipid transport across blood-brain barrier GO:1903002 IEA     positive regulation of lipid transport across blood-brain barrier GO:1903002 ISO     positive regulation of heparan sulfate proteoglycan binding GO:1905860 ISO     regulation of cellular response to very-low-density lipoprotein particle stimulus GO:1905890 IEA     regulation of cellular response to very-low-density lipoprotein particle stimulus GO:1905890 ISO     regulation of amyloid fibril formation GO:1905906 ISO     negative regulation of amyloid fibril formation GO:1905907 IMP     positive regulation of CoA-transferase activity GO:1905920 IMP     positive regulation of CoA-transferase activity GO:1905920 ISO     regulation of behavioral fear response GO:2000822 IEA     regulation of behavioral fear response GO:2000822 ISO Subcellular Localization     extracellular region GO:0005576 ISO     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IDA     extracellular space GO:0005615 ISO     nuclear envelope GO:0005635 ISO     endosome GO:0005768 ISO     early endosome GO:0005769 ISO     late endosome GO:0005770 ISO     endoplasmic reticulum GO:0005783 IEA     endoplasmic reticulum GO:0005783 ISO     Golgi apparatus GO:0005794 IEA     Golgi apparatus GO:0005794 ISO     cytosol GO:0005829 TAS     microtubule GO:0005874 ISO     cell surface GO:0009986 ISO     dendrite GO:0030425 ISO     extracellular matrix GO:0031012 ISO     extracellular matrix GO:0031012 ISS     extrinsic component of external side of plasma membrane GO:0031232 ISO     chylomicron remnant GO:0034360 IEA     chylomicron remnant GO:0034360 ISO     very-low-density lipoprotein particle GO:0034361 IBA     very-low-density lipoprotein particle GO:0034361 ISO     very-low-density lipoprotein particle GO:0034361 ISS     low-density lipoprotein particle GO:0034362 IBA     low-density lipoprotein particle GO:0034362 IDA     low-density lipoprotein particle GO:0034362 ISO     intermediate-density lipoprotein particle GO:0034363 ISO     intermediate-density lipoprotein particle GO:0034363 ISS     high-density lipoprotein particle GO:0034364 IBA     high-density lipoprotein particle GO:0034364 ISO     high-density lipoprotein particle GO:0034364 ISS     discoidal high-density lipoprotein particle GO:0034365 ISO     melanosome GO:0042470 IEA     melanosome GO:0042470 ISO     chylomicron GO:0042627 IBA     chylomicron GO:0042627 ISO     neuronal cell body GO:0043025 ISO     synaptic cleft GO:0043083 IEA     synaptic cleft GO:0043083 ISO     extracellular exosome GO:0070062 IEA     extracellular exosome GO:0070062 ISO     multivesicular body, internal vesicle GO:0097487 IEA     multivesicular body, internal vesicle GO:0097487 ISO     glutamatergic synapse GO:0098978 IDA     glutamatergic synapse GO:0098978 IMP     glutamatergic synapse GO:0098978 ISO     extracellular vesicle GO:1903561 IBA     lipoprotein particle GO:1990777 ISO