Gene description for Cox7a2
Gene name cytochrome c oxidase subunit VIIa 2
Gene symbol Cox7a2
Other names/aliases COX7AL
Cox7a3
CoxVIIa-L
Species Mus musculus
 Database cross references - Cox7a2
ExoCarta ExoCarta_12866
Vesiclepedia VP_12866
Entrez Gene 12866
UniProt P48771  
 Cox7a2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cox7a2
Molecular Function
    molecular_function GO:0003674 ND
    oxidoreductase activity GO:0016491 IEA
Biological Process
    regulation of oxidative phosphorylation GO:0002082 IBA
    mitochondrial electron transport, cytochrome c to oxygen GO:0006123 IEA
    mitochondrial respirasome assembly GO:0097250 IBA
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrial inner membrane GO:0005743 HDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial membrane GO:0031966 ISO
    respiratory chain complex IV GO:0045277 IDA
    respiratory chain complex IV GO:0045277 ISO
    respiratory chain complex GO:0098803 IBA
 Experiment description of studies that identified Cox7a2 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cox7a2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ndufa6  
Co-fractionation Mus musculus
2 Ndufa7  
Co-fractionation Mus musculus
3 Ndufa3  
Co-fractionation Mus musculus
4 Ndufb10  
Co-fractionation Mus musculus
5 SNCA 6622
Affinity Capture-MS Homo sapiens
6 Uqcr10  
Co-fractionation Mus musculus
7 Atp5j2  
Co-fractionation Mus musculus
8 Atp5l  
Co-fractionation Mus musculus
9 Ndufa5  
Co-fractionation Mus musculus
10 Ndufc2  
Co-fractionation Mus musculus
11 Uqcrc2 67003
Cross-Linking-MS (XL-MS) Mus musculus
Co-fractionation Mus musculus
12 Cox7c  
Co-fractionation Mus musculus
13 Unk  
Affinity Capture-RNA Mus musculus
14 Ndufs3 68349
Co-fractionation Mus musculus
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