Gene description for Uqcrc2
Gene name ubiquinol cytochrome c reductase core protein 2
Gene symbol Uqcrc2
Other names/aliases 1500004O06Rik
Species Mus musculus
 Database cross references - Uqcrc2
ExoCarta ExoCarta_67003
Vesiclepedia VP_67003
Entrez Gene 67003
UniProt Q9DB77  
 Uqcrc2 identified in sEVs derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Uqcrc2
Molecular Function
    metalloendopeptidase activity GO:0004222 IEA
    protein binding GO:0005515 IPI
    protein-containing complex binding GO:0044877 IEA
    protein-containing complex binding GO:0044877 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122 NAS
    proteolysis GO:0006508 IEA
    response to xenobiotic stimulus GO:0009410 IEA
    cellular respiration GO:0045333 NAS
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 HDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 ISO
    myelin sheath GO:0043209 HDA
    respiratory chain complex III GO:0045275 IDA
    respiratory chain complex III GO:0045275 ISO
    respiratory chain complex IV GO:0045277 ISO
 Experiment description of studies that identified Uqcrc2 in sEVs
1
Experiment ID 1117
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1118
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Uqcrc2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Got2 14719
Co-fractionation Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
2 Sdhb 67680
Co-fractionation Mus musculus
3 Idh2 269951
Cross-Linking-MS (XL-MS) Mus musculus
4 Pdha1  
Co-fractionation Mus musculus
5 SNCA 6622
Affinity Capture-MS Homo sapiens
6 Cox6b1  
Co-fractionation Mus musculus
7 Cyc1  
Co-fractionation Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
8 Atp5j  
Co-fractionation Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
9 Coq9  
Co-fractionation Mus musculus
10 Atp5d  
Co-fractionation Mus musculus
11 Uqcrh  
Co-fractionation Mus musculus
12 Ndufv2  
Co-fractionation Mus musculus
13 Ndufa6  
Co-fractionation Mus musculus
14 Cisd1  
Co-fractionation Mus musculus
15 Cycs 13063
Co-fractionation Mus musculus
16 Ndufab1  
Co-fractionation Mus musculus
17 Atp5e  
Co-fractionation Mus musculus
18 Cox7a2 12866
Co-fractionation Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
19 Atp5f1  
Co-fractionation Mus musculus
20 Mlf2  
Co-fractionation Mus musculus
21 Kctd13  
Affinity Capture-MS Mus musculus
22 Thrb  
Affinity Capture-MS Mus musculus
23 Ndufc2  
Co-fractionation Mus musculus
24 Ndufa2  
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
25 Uqcrc1  
Co-fractionation Mus musculus
26 Htt  
Affinity Capture-MS Mus musculus
27 Cox7a1  
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
28 Cox5a  
Co-fractionation Mus musculus
29 Sucla2  
Co-fractionation Mus musculus
30 Atp5b 11947
Co-fractionation Mus musculus
31 Atp5o 28080
Co-fractionation Mus musculus
32 Ndufb6  
Co-fractionation Mus musculus
33 Atp5k  
Co-fractionation Mus musculus
34 Dld 13382
Co-fractionation Mus musculus
35 Sdha 66945
Co-fractionation Mus musculus
36 Ndufs5  
Co-fractionation Mus musculus
37 Ndufs1  
Co-fractionation Mus musculus
38 Slc25a4 11739
Co-fractionation Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
39 Atp5j2  
Co-fractionation Mus musculus
40 Atp5a1 11946
Co-fractionation Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
41 Atp5l  
Co-fractionation Mus musculus
42 Idh3a 67834
Co-fractionation Mus musculus
43 Ndufb7  
Co-fractionation Mus musculus
44 Uqcrb  
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
45 Cs 12974
Co-fractionation Mus musculus
46 CYTB  
Cross-Linking-MS (XL-MS) Mus musculus
47 Ndufv3  
Co-fractionation Mus musculus
48 Ndufb9  
Cross-Linking-MS (XL-MS) Mus musculus
49 Suclg1  
Co-fractionation Mus musculus
50 Csl  
Cross-Linking-MS (XL-MS) Mus musculus
51 Kcnd3  
Co-fractionation Mus musculus
52 Ndufa3  
Co-fractionation Mus musculus
53 Uqcr10  
Co-fractionation Mus musculus
54 Ndufv1  
Co-fractionation Mus musculus
55 Ndufa4  
Co-fractionation Mus musculus
56 Eed  
Affinity Capture-MS Mus musculus
57 Ndufa10  
Co-fractionation Mus musculus
58 Ndufs2  
Co-fractionation Mus musculus
59 Uqcrc2 67003
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
60 Aco2 11429
Co-fractionation Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
61 Uqcrfs1 66694
Co-fractionation Mus musculus
62 Idh3g  
Co-fractionation Mus musculus
63 Ndufs4  
Co-fractionation Mus musculus
64 Atp5c1  
Co-fractionation Mus musculus
65 Fancd2  
Affinity Capture-MS Mus musculus
66 Mdh2 17448
Co-fractionation Mus musculus
67 Pdhb 68263
Co-fractionation Mus musculus
68 Dlat  
Co-fractionation Mus musculus
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