Gene description for Sdhb
Gene name succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene symbol Sdhb
Other names/aliases 0710008N11Rik
Species Mus musculus
 Database cross references - Sdhb
ExoCarta ExoCarta_67680
Vesiclepedia VP_67680
Entrez Gene 67680
UniProt Q9CQA3  
 Sdhb identified in sEVs derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
Pancreatic cells 19351151    
 Gene ontology annotations for Sdhb
Molecular Function
    succinate dehydrogenase (quinone) activity GO:0008177 ISO
    succinate dehydrogenase (quinone) activity GO:0008177 ISS
    electron transfer activity GO:0009055 IEA
    metal ion binding GO:0046872 IEA
    ubiquinone binding GO:0048039 ISS
    2 iron, 2 sulfur cluster binding GO:0051537 ISS
    3 iron, 4 sulfur cluster binding GO:0051538 ISS
    4 iron, 4 sulfur cluster binding GO:0051539 ISS
Biological Process
    tricarboxylic acid cycle GO:0006099 IEA
    tricarboxylic acid cycle GO:0006099 NAS
    succinate metabolic process GO:0006105 ISO
    mitochondrial electron transport, succinate to ubiquinone GO:0006121 NAS
    aerobic respiration GO:0009060 IBA
    respiratory electron transport chain GO:0022904 IBA
    respiratory electron transport chain GO:0022904 ISO
    proton motive force-driven mitochondrial ATP synthesis GO:0042776 NAS
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 HDA
    mitochondrial inner membrane GO:0005743 ISO
    mitochondrial inner membrane GO:0005743 ISS
    mitochondrial inner membrane GO:0005743 NAS
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    mitochondrial membrane GO:0031966 IBA
    respiratory chain complex II (succinate dehydrogenase) GO:0045273 IDA
    respiratory chain complex II (succinate dehydrogenase) GO:0045273 ISS
 Experiment description of studies that identified Sdhb in sEVs
1
Experiment ID 1117
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1118
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 188
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Sdhb
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Got2 14719
Co-fractionation Mus musculus
2 Pdha1  
Co-fractionation Mus musculus
3 Atp5j  
Co-fractionation Mus musculus
4 Ndufv3  
Co-fractionation Mus musculus
5 Ndufa6  
Co-fractionation Mus musculus
6 Ndufb5  
Co-fractionation Mus musculus
7 Coq9  
Co-fractionation Mus musculus
8 Cox6c  
Co-fractionation Mus musculus
9 Hadha  
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
10 Slc25a4 11739
Co-fractionation Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
11 Cox5a  
Co-fractionation Mus musculus
12 Ndufa9 66108
Cross-Linking-MS (XL-MS) Mus musculus
13 Ogdh 18293
Co-fractionation Mus musculus
14 Cycs 13063
Co-fractionation Mus musculus
15 Kcnma1  
Affinity Capture-MS Mus musculus
16 Atp5e  
Co-fractionation Mus musculus
17 Ndufa12  
Co-fractionation Mus musculus
18 Atxn1  
Affinity Capture-MS Mus musculus
19 Ndufc2  
Co-fractionation Mus musculus
20 Uqcrc1  
Co-fractionation Mus musculus
21 Cox6b1  
Co-fractionation Mus musculus
22 Aco2 11429
Co-fractionation Mus musculus
23 HSD17B10 3028
Affinity Capture-MS Homo sapiens
24 Atp5l  
Co-fractionation Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
25 Sucla2  
Co-fractionation Mus musculus
26 Atp5b 11947
Co-fractionation Mus musculus
27 Ndufs2  
Co-fractionation Mus musculus
28 Dlst  
Co-fractionation Mus musculus
29 Atp5k  
Co-fractionation Mus musculus
30 Ndufs5  
Co-fractionation Mus musculus
31 Ndufs1  
Co-fractionation Mus musculus
32 Atp5j2  
Co-fractionation Mus musculus
33 Atp5a1 11946
Co-fractionation Mus musculus
34 Cox7a1  
Cross-Linking-MS (XL-MS) Mus musculus
35 Fh1 14194
Co-fractionation Mus musculus
36 Sdha 66945
Co-fractionation Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
37 Slc25a5 11740
Co-fractionation Mus musculus
38 Suclg1  
Co-fractionation Mus musculus
39 Cartpt  
Two-hybrid Mus musculus
40 Chchd3  
Co-fractionation Mus musculus
41 Uqcr10  
Co-fractionation Mus musculus
42 Ndufa4  
Co-fractionation Mus musculus
43 Sdhb 67680
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
Cross-Linking-MS (XL-MS) Mus musculus
44 Ndufa10  
Co-fractionation Mus musculus
45 Uqcrc2 67003
Co-fractionation Mus musculus
46 Dld 13382
Co-fractionation Mus musculus
47 Ndufb6  
Co-fractionation Mus musculus
48 Idh3g  
Co-fractionation Mus musculus
49 Atp5c1  
Co-fractionation Mus musculus
50 Fancd2  
Affinity Capture-MS Mus musculus
51 Mdh2 17448
Co-fractionation Mus musculus
52 Uqcrfs1 66694
Co-fractionation Mus musculus
53 Dlat  
Co-fractionation Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here