Gene description for Dbnl
Gene name drebrin-like
Gene symbol Dbnl
Other names/aliases Abp1
SH3P7
mAbp1
Species Mus musculus
 Database cross references - Dbnl
ExoCarta ExoCarta_13169
Vesiclepedia VP_13169
Entrez Gene 13169
UniProt Q62418  
 Dbnl identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Dbnl
Molecular Function
    actin binding GO:0003779 IDA
    protein binding GO:0005515 IPI
    protein domain specific binding GO:0019904 IDA
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 IDA
    structural constituent of postsynaptic actin cytoskeleton GO:0098973 IEA
    structural constituent of postsynaptic actin cytoskeleton GO:0098973 ISO
Biological Process
    adaptive immune response GO:0002250 IEA
    endocytosis GO:0006897 IEA
    synapse assembly GO:0007416 IMP
    Rac protein signal transduction GO:0016601 IDA
    regulation of actin filament polymerization GO:0030833 IBA
    positive regulation of axon extension GO:0045773 IBA
    neuron projection morphogenesis GO:0048812 IBA
    neuron projection morphogenesis GO:0048812 IMP
    actin filament severing GO:0051014 IDA
    barbed-end actin filament capping GO:0051016 IDA
    actin filament bundle assembly GO:0051017 IDA
    positive regulation of dendritic spine morphogenesis GO:0061003 IBA
    podosome assembly GO:0071800 IMP
    postsynaptic actin cytoskeleton organization GO:0098974 IBA
    postsynaptic actin cytoskeleton organization GO:0098974 IEA
    postsynaptic actin cytoskeleton organization GO:0098974 ISO
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    ruffle GO:0001726 IDA
    podosome GO:0002102 IDA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    early endosome GO:0005769 IEA
    cytosol GO:0005829 IEA
    actin filament GO:0005884 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    cell cortex GO:0005938 IDA
    postsynaptic density GO:0014069 IBA
    postsynaptic density GO:0014069 IEA
    lamellipodium GO:0030027 IBA
    lamellipodium GO:0030027 IDA
    dendrite GO:0030425 IBA
    dendrite GO:0030425 IEA
    dendrite GO:0030425 ISO
    site of polarized growth GO:0030427 IBA
    clathrin-coated vesicle membrane GO:0030665 IEA
    cortical actin cytoskeleton GO:0030864 IBA
    perikaryon GO:0043204 IEA
    intracellular membrane-bounded organelle GO:0043231 ISO
    postsynaptic membrane GO:0045211 IBA
    anchoring junction GO:0070161 IEA
    presynapse GO:0098793 IEA
    presynapse GO:0098793 ISO
    postsynapse GO:0098794 ISO
    glutamatergic synapse GO:0098978 IEA
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Dbnl in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Dbnl
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Invs  
Affinity Capture-MS Mus musculus
2 Tpm3 59069
Co-fractionation Mus musculus
3 Wdr4  
Co-fractionation Mus musculus
4 Tmem173  
Proximity Label-MS Mus musculus
5 Foxp3  
Affinity Capture-MS Mus musculus
6 Kctd13  
Affinity Capture-MS Mus musculus
7 Atg16l1  
Affinity Capture-MS Mus musculus
8 Tpm4  
Co-fractionation Mus musculus
9 Uba5  
Co-fractionation Mus musculus
10 Fancd2  
Affinity Capture-MS Mus musculus
11 Ywhae 22627
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Dbnl is involved
No pathways found





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