Gene description for CPE
Gene name carboxypeptidase E
Gene symbol CPE
Other names/aliases -
Species Homo sapiens
 Database cross references - CPE
ExoCarta ExoCarta_1363
Vesiclepedia VP_1363
Entrez Gene 1363
HGNC 2303
MIM 114855
UniProt P16870  
 CPE identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CPE
Molecular Function
    carboxypeptidase activity GO:0004180 TAS
    metallocarboxypeptidase activity GO:0004181 IBA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    neurexin family protein binding GO:0042043 IPI
    cell adhesion molecule binding GO:0050839 IPI
Biological Process
    cardiac left ventricle morphogenesis GO:0003214 IMP
    peptide metabolic process GO:0006518 IBA
    neuropeptide signaling pathway GO:0007218 NAS
    Wnt signaling pathway GO:0016055 IDA
    protein processing GO:0016485 IBA
    insulin processing GO:0030070 IEA
    peptide hormone secretion GO:0030072 IEA
    protein localization to secretory granule GO:0033366 IEA
    protein modification process GO:0036211 NAS
    protein localization to membrane GO:0072657 IDA
Subcellular Localization
    extracellular space GO:0005615 IBA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 TAS
    transport vesicle membrane GO:0030658 IEA
    secretory granule membrane GO:0030667 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CPE in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CPE
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UGGT2 55757
Affinity Capture-MS Homo sapiens
2 GPM6A 2823
Affinity Capture-MS Homo sapiens
3 CSTL1  
Affinity Capture-MS Homo sapiens
4 PRKAA1 5562
Affinity Capture-Western Homo sapiens
5 CHD3 1107
Two-hybrid Homo sapiens
6 CEACAM8 1088
Affinity Capture-MS Homo sapiens
7 PSG1  
Affinity Capture-MS Homo sapiens
8 SIAE 54414
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TMEM87A 25963
Affinity Capture-MS Homo sapiens
10 SCGB1D1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 PRNP 5621
Affinity Capture-MS Homo sapiens
12 TTC28 23331
Affinity Capture-MS Homo sapiens
13 C7orf34  
Affinity Capture-MS Homo sapiens
14 RNASE13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 GTF3C1  
Two-hybrid Homo sapiens
16 RPA1 6117
Two-hybrid Homo sapiens
17 UTP14A 10813
Two-hybrid Homo sapiens
18 RLN1  
Affinity Capture-MS Homo sapiens
19 GPIHBP1  
Affinity Capture-MS Homo sapiens
20 SLAMF1 6504
Affinity Capture-MS Homo sapiens
21 SERPINB11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 LRIF1  
Two-hybrid Homo sapiens
23 POLA2  
Two-hybrid Homo sapiens
24 PECR 55825
Affinity Capture-MS Homo sapiens
25 BRICD5  
Affinity Capture-MS Homo sapiens
26 GIP  
Affinity Capture-MS Homo sapiens
27 ROBO2 6092
Two-hybrid Homo sapiens
28 PROK2  
Affinity Capture-MS Homo sapiens
29 NUFIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 POLDIP2 26073
Two-hybrid Homo sapiens
31 HYOU1 10525
Affinity Capture-MS Homo sapiens
32 DHFRL1  
Affinity Capture-MS Homo sapiens
33 PATE1  
Affinity Capture-MS Homo sapiens
34 FAM19A2 338811
Affinity Capture-MS Homo sapiens
35 BAGE2  
Affinity Capture-MS Homo sapiens
36 ST14 6768
Affinity Capture-MS Homo sapiens
37 MED31  
Two-hybrid Homo sapiens
38 B3GALT5  
Affinity Capture-MS Homo sapiens
39 PSG8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 TMPRSS13  
Affinity Capture-MS Homo sapiens
41 PSMC3 5702
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CPE is involved
PathwayEvidenceSource
Insulin processing IEA Reactome
Metabolism of proteins IEA Reactome
Peptide hormone metabolism IEA Reactome





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