Gene description for Fas
Gene name	Fas (TNF receptor superfamily member 6)
Gene symbol	Fas
Other names/aliases	AI196731 APO1 APT1 CD95 TNFR6 Tnfrsf6 lpr
Species	Mus musculus
Database cross references - Fas
ExoCarta	ExoCarta_14102
Vesiclepedia	VP_14102
Entrez Gene	14102
UniProt	P25446
Fas identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Fas

Molecular Function     protease binding GO:0002020 ISO     transmembrane signaling receptor activity GO:0004888 IEA     tumor necrosis factor receptor activity GO:0005031 IBA     tumor necrosis factor receptor activity GO:0005031 ISO     protein binding GO:0005515 IPI     calmodulin binding GO:0005516 ISO     calmodulin binding GO:0005516 ISS     kinase binding GO:0019900 ISO     protein phosphatase binding GO:0019903 ISO     identical protein binding GO:0042802 IDA     identical protein binding GO:0042802 ISO     protein-containing complex binding GO:0044877 ISO Biological Process     positive regulation of protein phosphorylation GO:0001934 ISO     immunoglobulin production GO:0002377 IMP     apoptotic process GO:0006915 IMP     apoptotic process GO:0006915 ISO     activation-induced cell death of T cells GO:0006924 IBA     activation-induced cell death of T cells GO:0006924 IDA     activation-induced cell death of T cells GO:0006924 IMP     inflammatory cell apoptotic process GO:0006925 IDA     inflammatory cell apoptotic process GO:0006925 IMP     circadian rhythm GO:0007623 IEP     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IDA     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IDA     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IGI     extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IMP     response to toxic substance GO:0009636 IMP     gene expression GO:0010467 IMP     negative regulation of Schwann cell proliferation GO:0010626 ISO     B cell mediated immunity GO:0019724 IMP     dendrite regeneration GO:0031104 ISO     positive regulation of protein-containing complex assembly GO:0031334 IDA     regulation of stress-activated MAPK cascade GO:0032872 IBA     regulation of stress-activated MAPK cascade GO:0032872 ISO     cellular response to amino acid starvation GO:0034198 ISO     Fas signaling pathway GO:0036337 ISO     regulation of cell population proliferation GO:0042127 ISO     regulation of apoptotic process GO:0042981 ISO     T cell homeostasis GO:0043029 IMP     positive regulation of apoptotic process GO:0043065 ISO     negative regulation of apoptotic process GO:0043066 IBA     negative regulation of apoptotic process GO:0043066 IDA     positive regulation of neuron apoptotic process GO:0043525 ISO     negative thymic T cell selection GO:0045060 IMP     regulation of B cell differentiation GO:0045577 IMP     regulation of T cell differentiation GO:0045580 IMP     regulation of myeloid cell differentiation GO:0045637 IMP     spleen development GO:0048536 IMP     negative regulation of B cell activation GO:0050869 IMP     response to glucocorticoid GO:0051384 IMP     neuron apoptotic process GO:0051402 IMP     lymphocyte apoptotic process GO:0070227 IDA     cellular response to lithium ion GO:0071285 IMP     cellular response to hyperoxia GO:0071455 ISO     positive regulation of release of cytochrome c from mitochondria GO:0090200 IC     motor neuron apoptotic process GO:0097049 IBA     motor neuron apoptotic process GO:0097049 IMP     apoptotic signaling pathway GO:0097190 IDA     apoptotic signaling pathway GO:0097190 ISO     extrinsic apoptotic signaling pathway GO:0097191 IDA     extrinsic apoptotic signaling pathway GO:0097191 IMP     extrinsic apoptotic signaling pathway GO:0097191 ISO     extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IMP     hepatocyte apoptotic process GO:0097284 IGI     necroptotic signaling pathway GO:0097527 IBA     necroptotic signaling pathway GO:0097527 IGI     necroptotic signaling pathway GO:0097527 ISO     negative regulation of Schwann cell migration GO:1900148 ISO     regulation of hematopoietic progenitor cell differentiation GO:1901532 IMP     positive regulation of cysteine-type endopeptidase activity GO:2001056 ISO     positive regulation of apoptotic signaling pathway GO:2001235 ISO Subcellular Localization     extracellular region GO:0005576 IDA     extracellular space GO:0005615 ISO     cytosol GO:0005829 ISO     plasma membrane GO:0005886 ISO     external side of plasma membrane GO:0009897 IBA     external side of plasma membrane GO:0009897 IDA     external side of plasma membrane GO:0009897 ISO     cell surface GO:0009986 IDA     cell surface GO:0009986 ISO     apical plasma membrane GO:0016324 ISO     nuclear body GO:0016604 ISO     secretory granule GO:0030141 ISO     death-inducing signaling complex GO:0031264 ISO     CD95 death-inducing signaling complex GO:0031265 IBA     CD95 death-inducing signaling complex GO:0031265 IDA     CD95 death-inducing signaling complex GO:0031265 ISO     sarcolemma GO:0042383 ISO     neuronal cell body GO:0043025 ISO     membrane raft GO:0045121 IBA     membrane raft GO:0045121 IEA     membrane raft GO:0045121 ISO     perinuclear region of cytoplasm GO:0048471 ISO     apical dendrite GO:0097440 ISO