Gene description for A2ML1
Gene name alpha-2-macroglobulin-like 1
Gene symbol A2ML1
Other names/aliases CPAMD9
Species Homo sapiens
 Database cross references - A2ML1
ExoCarta ExoCarta_144568
Vesiclepedia VP_144568
Entrez Gene 144568
HGNC 23336
MIM 610627
UniProt A8K2U0  
 A2ML1 identified in sEVs derived from the following tissue/cell type
Saliva 19199708    
Urine 19056867    
 Gene ontology annotations for A2ML1
Molecular Function
    serine-type endopeptidase inhibitor activity GO:0004867 IEA
    peptidase inhibitor activity GO:0030414 IDA
Biological Process
    regulation of endopeptidase activity GO:0052548 IDA
Subcellular Localization
    extracellular space GO:0005615 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified A2ML1 in sEVs
1
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for A2ML1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NFAM1  
Affinity Capture-MS Homo sapiens
2 TNFAIP3 7128
Affinity Capture-MS Homo sapiens
3 POLDIP3 84271
Affinity Capture-MS Homo sapiens
4 CMTR2  
Co-fractionation Homo sapiens
5 NRSN1  
Affinity Capture-MS Homo sapiens
6 RPS19BP1  
Affinity Capture-MS Homo sapiens
7 RTCA 8634
Affinity Capture-MS Homo sapiens
8 MBD4  
Affinity Capture-MS Homo sapiens
9 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ARMC1 55156
Co-fractionation Homo sapiens
11 TLR7  
Affinity Capture-MS Homo sapiens
12 PLAC8L1  
Affinity Capture-MS Homo sapiens
13 ST7  
Affinity Capture-MS Homo sapiens
14 SOX2  
Affinity Capture-MS Homo sapiens
15 FNDC5  
Affinity Capture-MS Homo sapiens
16 PI4KA 5297
Affinity Capture-MS Homo sapiens
17 HSF2  
Affinity Capture-MS Homo sapiens
18 GPATCH2L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 L2HGDH  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 ZDHHC6  
Affinity Capture-MS Homo sapiens
21 SLC39A11  
Affinity Capture-MS Homo sapiens
22 GRK4  
Affinity Capture-MS Homo sapiens
23 NUDT3 11165
Affinity Capture-MS Homo sapiens
24 UGT1A10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 FMNL2 114793
Affinity Capture-MS Homo sapiens
26 THAP10  
Affinity Capture-MS Homo sapiens
27 PHF11 51131
Affinity Capture-MS Homo sapiens
28 FOXD4  
Affinity Capture-MS Homo sapiens
29 GPN1  
Affinity Capture-MS Homo sapiens
30 C18orf21  
Affinity Capture-MS Homo sapiens
31 ZFAND4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 DUS2 54920
Co-fractionation Homo sapiens
33 ZNF550  
Affinity Capture-MS Homo sapiens
34 FCRL5  
Affinity Capture-MS Homo sapiens
35 BAK1 578
Affinity Capture-MS Homo sapiens
36 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
37 LRRC10  
Affinity Capture-MS Homo sapiens
38 CERS3  
Affinity Capture-MS Homo sapiens
39 RNF115  
Affinity Capture-MS Homo sapiens
40 SRRT 51593
Affinity Capture-MS Homo sapiens
41 ASCL1  
Affinity Capture-MS Homo sapiens
42 RASSF9  
Affinity Capture-MS Homo sapiens
43 SARAF  
Affinity Capture-MS Homo sapiens
44 PIGT 51604
Affinity Capture-MS Homo sapiens
45 TOX4  
Affinity Capture-MS Homo sapiens
46 SSUH2  
Affinity Capture-MS Homo sapiens
47 FGFRL1 53834
Affinity Capture-MS Homo sapiens
48 HCN1  
Affinity Capture-MS Homo sapiens
49 APTX  
Affinity Capture-MS Homo sapiens
50 UPK1A 11045
Affinity Capture-MS Homo sapiens
51 BEX5  
Affinity Capture-MS Homo sapiens
52 DDX39B 7919
Affinity Capture-MS Homo sapiens
53 SCN3B  
Affinity Capture-MS Homo sapiens
54 UPP1 7378
Affinity Capture-MS Homo sapiens
55 FSTL1 11167
Affinity Capture-MS Homo sapiens
56 FOXH1  
Affinity Capture-MS Homo sapiens
57 MRM1  
Affinity Capture-MS Homo sapiens
58 RHBDD1 84236
Affinity Capture-MS Homo sapiens
59 SPTBN4 57731
Affinity Capture-MS Homo sapiens
60 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
61 NDST2  
Affinity Capture-MS Homo sapiens
62 AGPAT1 10554
Affinity Capture-MS Homo sapiens
63 ZFPL1 7542
Affinity Capture-MS Homo sapiens
64 NT5C1A  
Affinity Capture-MS Homo sapiens
65 CCNYL1 151195
Affinity Capture-MS Homo sapiens
66 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 MOGAT3  
Affinity Capture-MS Homo sapiens
68 PCP4  
Affinity Capture-MS Homo sapiens
69 ZSCAN12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 NPPA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
72 FTH1 2495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 CORO1C 23603
Affinity Capture-MS Homo sapiens
74 THRA  
Affinity Capture-MS Homo sapiens
75 FRMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 PI4KAP1  
Affinity Capture-MS Homo sapiens
77 COA5  
Affinity Capture-MS Homo sapiens
78 GSTK1 373156
Affinity Capture-MS Homo sapiens
79 PABPN1L  
Affinity Capture-MS Homo sapiens
80 ACAD9 28976
Affinity Capture-MS Homo sapiens
81 DUSP21  
Affinity Capture-MS Homo sapiens
82 GMCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 FAM213A 84293
Affinity Capture-MS Homo sapiens
84 YAF2  
Affinity Capture-MS Homo sapiens
85 STX17 55014
Affinity Capture-MS Homo sapiens
86 RIPPLY3  
Affinity Capture-MS Homo sapiens
87 HUWE1 10075
Affinity Capture-MS Homo sapiens
88 FAM153B  
Affinity Capture-MS Homo sapiens
89 DYNLL2 140735
Affinity Capture-MS Homo sapiens
90 SLC25A6 293
Affinity Capture-MS Homo sapiens
91 WWOX 51741
Affinity Capture-MS Homo sapiens
92 SH2D3A  
Affinity Capture-MS Homo sapiens
93 ZNF154  
Affinity Capture-MS Homo sapiens
94 NHLRC2 374354
Affinity Capture-MS Homo sapiens
95 C1orf35  
Affinity Capture-MS Homo sapiens
96 GSKIP  
Affinity Capture-MS Homo sapiens
97 TREX2  
Affinity Capture-MS Homo sapiens
98 FBXO44  
Affinity Capture-MS Homo sapiens
99 KLHL11  
Affinity Capture-MS Homo sapiens
100 ERCC3  
Affinity Capture-MS Homo sapiens
101 MBNL1 4154
Affinity Capture-MS Homo sapiens
102 TEFM  
Affinity Capture-MS Homo sapiens
103 PINK1  
Affinity Capture-MS Homo sapiens
104 UBALD2  
Affinity Capture-MS Homo sapiens
105 GOT1 2805
Affinity Capture-MS Homo sapiens
106 STK11 6794
Affinity Capture-MS Homo sapiens
107 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 OR2A4 79541
Affinity Capture-MS Homo sapiens
109 INSC  
Affinity Capture-MS Homo sapiens
110 GABPA 2551
Affinity Capture-MS Homo sapiens
111 CCR1  
Affinity Capture-MS Homo sapiens
112 P2RX6  
Affinity Capture-MS Homo sapiens
113 GPR148  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which A2ML1 is involved
No pathways found





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