Gene description for SPTBN4
Gene name	spectrin, beta, non-erythrocytic 4
Gene symbol	SPTBN4
Other names/aliases	QV SPNB4 SPTBN3
Species	Homo sapiens
Database cross references - SPTBN4
ExoCarta	ExoCarta_57731
Vesiclepedia	VP_57731
Entrez Gene	57731
HGNC	14896
MIM	606214
UniProt	Q9H254
SPTBN4 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells	Unpublished / Not applicable
Prostate cancer cells	25844599
Squamous carcinoma cells	20124223

Gene ontology annotations for SPTBN4

Molecular Function     actin binding GO:0003779 ISS     structural constituent of cytoskeleton GO:0005200 TAS     protein binding GO:0005515 IPI     phospholipid binding GO:0005543 IEA     phosphatase binding GO:0019902 IPI     ankyrin binding GO:0030506 IDA     spectrin binding GO:0030507 ISS     actin filament binding GO:0051015 IBA     cytoskeletal protein-membrane anchor activity GO:0106006 TAS Biological Process     regulation of sodium ion transport GO:0002028 ISS     axonogenesis GO:0007409 ISS     neuromuscular junction development GO:0007528 IEA     sensory perception of sound GO:0007605 ISS     adult walking behavior GO:0007628 ISS     fertilization GO:0009566 IEA     negative regulation of heart rate GO:0010459 ISS     vesicle-mediated transport GO:0016192 TAS     transmission of nerve impulse GO:0019226 ISS     central nervous system projection neuron axonogenesis GO:0021952 IBA     central nervous system projection neuron axonogenesis GO:0021952 ISS     actin cytoskeleton organization GO:0030036 IBA     positive regulation of multicellular organism growth GO:0040018 IEA     clustering of voltage-gated sodium channels GO:0045162 ISS     neuromuscular process GO:0050905 IEA     actin filament capping GO:0051693 IEA     cardiac conduction GO:0061337 ISS     protein-containing complex assembly GO:0065003 IEA     protein localization to plasma membrane GO:0072659 ISS Subcellular Localization     cytoplasm GO:0005737 IDA     cytosol GO:0005829 TAS     actin filament GO:0005884 ISS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISS     adherens junction GO:0005912 ISS     spectrin GO:0008091 IDA     intercalated disc GO:0014704 IEA     membrane GO:0016020 IDA     nuclear matrix GO:0016363 IDA     PML body GO:0016605 IDA     cell junction GO:0030054 IBA     cortical actin cytoskeleton GO:0030864 IBA     node of Ranvier GO:0033268 ISS     paranode region of axon GO:0033270 IEA     cell projection GO:0042995 IBA     neuronal cell body GO:0043025 ISS     axon initial segment GO:0043194 ISS     axon hillock GO:0043203 ISS     juxtaparanode region of axon GO:0044224 IEA     extracellular exosome GO:0070062 HDA     cell body fiber GO:0070852 ISS