Gene description for Ghr
Gene name growth hormone receptor
Gene symbol Ghr
Other names/aliases GHBP
GHR/BP
Species Mus musculus
 Database cross references - Ghr
ExoCarta ExoCarta_14600
Vesiclepedia VP_14600
Entrez Gene 14600
UniProt P16882  
 Ghr identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ghr
Molecular Function
    growth hormone receptor activity GO:0004903 IBA
    growth hormone receptor activity GO:0004903 IDA
    growth hormone receptor activity GO:0004903 ISO
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 ISO
    peptide hormone binding GO:0017046 IBA
    peptide hormone binding GO:0017046 IPI
    peptide hormone binding GO:0017046 ISO
    growth factor binding GO:0019838 ISO
    protein kinase binding GO:0019901 ISO
    protein phosphatase binding GO:0019903 ISO
    cytokine binding GO:0019955 IBA
    SH2 domain binding GO:0042169 ISO
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
Biological Process
    endocytosis GO:0006897 IEA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 ISO
    positive regulation of cell population proliferation GO:0008284 IBA
    hormone-mediated signaling pathway GO:0009755 ISO
    cytokine-mediated signaling pathway GO:0019221 IBA
    cytokine-mediated signaling pathway GO:0019221 IEA
    taurine metabolic process GO:0019530 IMP
    receptor internalization GO:0031623 ISO
    regulation of response to nutrient levels GO:0032107 ISO
    response to estradiol GO:0032355 ISO
    cellular response to hormone stimulus GO:0032870 ISO
    regulation of multicellular organism growth GO:0040014 IMP
    positive regulation of multicellular organism growth GO:0040018 ISO
    hormone metabolic process GO:0042445 ISO
    positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 IBA
    positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 ISO
    response to cycloheximide GO:0046898 ISO
    insulin-like growth factor receptor signaling pathway GO:0048009 ISO
    growth hormone receptor signaling pathway GO:0060396 IBA
    growth hormone receptor signaling pathway GO:0060396 ISO
    growth hormone receptor signaling pathway via JAK-STAT GO:0060397 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 ISO
    nucleus GO:0005634 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    cell surface GO:0009986 ISO
    membrane GO:0016020 IDA
    membrane GO:0016020 ISO
    cytoplasmic ribonucleoprotein granule GO:0036464 ISO
    neuronal cell body GO:0043025 ISO
    receptor complex GO:0043235 ISO
    growth hormone receptor complex GO:0070195 IBA
    growth hormone receptor complex GO:0070195 ISO
 Experiment description of studies that identified Ghr in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ghr
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sirpa  
Biochemical Activity Mus musculus
2 Ptpn11 19247
Affinity Capture-Western Mus musculus
View the network image/svg+xml



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