Gene description for Hk2
Gene name	hexokinase 2
Gene symbol	Hk2
Other names/aliases	AI642394 HKII
Species	Mus musculus
Database cross references - Hk2
ExoCarta	ExoCarta_15277
Vesiclepedia	VP_15277
Entrez Gene	15277
UniProt	O08528
Hk2 identified in sEVs derived from the following tissue/cell type
Melanoma cells	34957415
Melanoma cells	34957415

Gene ontology annotations for Hk2

Molecular Function     glucokinase activity GO:0004340 IBA     glucokinase activity GO:0004340 ISO     glucokinase activity GO:0004340 ISS     hexokinase activity GO:0004396 IDA     hexokinase activity GO:0004396 IMP     hexokinase activity GO:0004396 ISO     hexokinase activity GO:0004396 ISS     ATP binding GO:0005524 IEA     ATP binding GO:0005524 ISO     D-glucose binding GO:0005536 IEA     D-glucose binding GO:0005536 ISO     fructokinase activity GO:0008865 IBA     fructokinase activity GO:0008865 ISO     fructokinase activity GO:0008865 ISS Biological Process     response to hypoxia GO:0001666 IEA     intracellular glucose homeostasis GO:0001678 IBA     intracellular glucose homeostasis GO:0001678 IEA     response to ischemia GO:0002931 IEA     response to ischemia GO:0002931 ISO     fructose 6-phosphate metabolic process GO:0006002 ISO     fructose 6-phosphate metabolic process GO:0006002 ISS     glucose metabolic process GO:0006006 IBA     glucose metabolic process GO:0006006 IMP     glycolytic process GO:0006096 IBA     glycolytic process GO:0006096 IEA     lactation GO:0007595 IEA     apoptotic mitochondrial changes GO:0008637 IGI     apoptotic mitochondrial changes GO:0008637 ISO     negative regulation of mitochondrial membrane permeability GO:0035795 IMP     positive regulation of angiogenesis GO:0045766 IEA     positive regulation of angiogenesis GO:0045766 ISO     regulation of D-glucose import GO:0046324 IMP     carbohydrate phosphorylation GO:0046835 IMP     carbohydrate phosphorylation GO:0046835 ISO     glucose 6-phosphate metabolic process GO:0051156 IBA     glucose 6-phosphate metabolic process GO:0051156 ISO     glucose 6-phosphate metabolic process GO:0051156 ISS     establishment of protein localization to mitochondrion GO:0072655 IEA     establishment of protein localization to mitochondrion GO:0072655 ISO     maintenance of protein location in mitochondrion GO:0072656 IEA     maintenance of protein location in mitochondrion GO:0072656 ISO     positive regulation of type 2 mitophagy GO:1905091 IEA     positive regulation of type 2 mitophagy GO:1905091 ISO     cellular response to leukemia inhibitory factor GO:1990830 IEP     negative regulation of reactive oxygen species metabolic process GO:2000378 IMP Subcellular Localization     mitochondrion GO:0005739 HDA     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 ISO     mitochondrial outer membrane GO:0005741 ISO     centrosome GO:0005813 IEA     centrosome GO:0005813 ISO     cytosol GO:0005829 IBA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     sarcoplasmic reticulum GO:0016529 IEA     sarcoplasmic reticulum GO:0016529 ISO     intracellular membrane-bounded organelle GO:0043231 ISO