Gene description for DDX11
Gene name	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
Gene symbol	DDX11
Other names/aliases	CHL1 CHLR1 KRG2 WABS
Species	Homo sapiens
Database cross references - DDX11
ExoCarta	ExoCarta_1663
Vesiclepedia	VP_1663
Entrez Gene	1663
HGNC	2736
MIM	601150
UniProt	Q96FC9
DDX11 identified in sEVs derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for DDX11

Molecular Function     DNA binding GO:0003677 IDA     DNA helicase activity GO:0003678 IBA     DNA helicase activity GO:0003678 IDA     chromatin binding GO:0003682 IDA     chromatin binding GO:0003682 IMP     DNA replication origin binding GO:0003688 IMP     DNA clamp loader activity GO:0003689 IEA     double-stranded DNA binding GO:0003690 IDA     single-stranded DNA binding GO:0003697 IDA     single-stranded RNA binding GO:0003727 IDA     helicase activity GO:0004386 IDA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     ATP-dependent activity, acting on DNA GO:0008094 IDA     ATP-dependent activity, acting on DNA GO:0008094 IMP     ATP-dependent activity, acting on RNA GO:0008186 IDA     four-way junction helicase activity GO:0009378 IEA     isomerase activity GO:0016853 IEA     ATP hydrolysis activity GO:0016887 IEA     double-stranded DNA helicase activity GO:0036121 IEA     5'-3' DNA helicase activity GO:0043139 IDA     triplex DNA binding GO:0045142 IDA     metal ion binding GO:0046872 IEA     4 iron, 4 sulfur cluster binding GO:0051539 IEA     G-quadruplex DNA binding GO:0051880 IDA     forked DNA-dependent helicase activity GO:0061749 IEA     cohesin loader activity GO:0061775 IEA     chromatin extrusion motor activity GO:0140584 IEA     ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA     ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA     single-stranded 3'-5' DNA helicase activity GO:1990518 IEA Biological Process     DNA repair GO:0006281 IEA     chromatin remodeling GO:0006338 IEA     DNA damage response GO:0006974 IMP     sister chromatid cohesion GO:0007062 IDA     replication fork processing GO:0031297 IMP     positive regulation of endodeoxyribonuclease activity GO:0032079 IDA     negative regulation of protein binding GO:0032091 IMP     DNA duplex unwinding GO:0032508 IBA     DNA duplex unwinding GO:0032508 IDA     establishment of sister chromatid cohesion GO:0034085 IBA     positive regulation of chromatin binding GO:0035563 IDA     G-quadruplex DNA unwinding GO:0044806 IDA     positive regulation of sister chromatid cohesion GO:0045876 IMP     cellular response to hydroxyurea GO:0072711 IMP     cellular response to cisplatin GO:0072719 IMP     chromatin looping GO:0140588 IEA     positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 IMP     cellular response to bleomycin GO:1904976 IMP     nucleolar chromatin organization GO:1990700 IMP     positive regulation of double-strand break repair GO:2000781 IMP Subcellular Localization     chromatin GO:0000785 IDA     spindle pole GO:0000922 IDA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     nucleolus GO:0005730 IDA     cytoplasm GO:0005737 IEA     centrosome GO:0005813 IDA     midbody GO:0030496 IDA     mitotic cohesin complex GO:0030892 IDA     Ctf18 RFC-like complex GO:0031390 IDA     extracellular exosome GO:0070062 HDA