Gene description for ZBTB49
Gene name zinc finger and BTB domain containing 49
Gene symbol ZBTB49
Other names/aliases ZNF509
Species Homo sapiens
 Database cross references - ZBTB49
ExoCarta ExoCarta_166793
Vesiclepedia VP_166793
Entrez Gene 166793
HGNC 19883
MIM 616238
UniProt Q6ZSB9  
 ZBTB49 identified in sEVs derived from the following tissue/cell type
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for ZBTB49
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    transcription coactivator binding GO:0001223 IPI
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IBA
    protein binding GO:0005515 IPI
    sequence-specific DNA binding GO:0043565 IDA
    metal ion binding GO:0046872 IEA
    DNA-binding transcription factor binding GO:0140297 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    regulation of cytokine production GO:0001817 IBA
    regulation of immune system process GO:0002682 IBA
    negative regulation of cell population proliferation GO:0008285 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    regulation of cell cycle GO:0051726 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    microtubule cytoskeleton GO:0015630 IDA
 Experiment description of studies that identified ZBTB49 in sEVs
1
Experiment ID 196
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 197
MISEV standards
EM
Biophysical techniques
Alix|TSG101|HSP70|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ZBTB49
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSD2  
Affinity Capture-MS Homo sapiens
2 ZBTB17  
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
3 ZBTB2 57621
Two-hybrid Homo sapiens
4 TRAF2 7186
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 POT1  
Two-hybrid Homo sapiens
6 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 VAC14 55697
Two-hybrid Homo sapiens
8 ZBTB8A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 GOPC 57120
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
10 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
11 DIEXF  
Affinity Capture-MS Homo sapiens
12 TRAF3 7187
Two-hybrid Homo sapiens
13 OTUD4  
Affinity Capture-MS Homo sapiens
14 SREBF2 6721
Positive Genetic Homo sapiens
15 CEP70  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
16 TRIM21 6737
Affinity Capture-MS Homo sapiens
17 WDR83  
Affinity Capture-MS Homo sapiens
18 KAT5  
Affinity Capture-Western Homo sapiens
19 TCEB2 6923
Affinity Capture-MS Homo sapiens
20 CIB1 10519
Two-hybrid Homo sapiens
21 HINFP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
22 EP300 2033
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which ZBTB49 is involved
No pathways found





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