Gene description for SREBF2
Gene name	sterol regulatory element binding transcription factor 2
Gene symbol	SREBF2
Other names/aliases	SREBP-2 SREBP2 bHLHd2
Species	Homo sapiens
Database cross references - SREBF2
ExoCarta	ExoCarta_6721
Vesiclepedia	VP_6721
Entrez Gene	6721
HGNC	11290
MIM	600481
UniProt	Q12772
SREBF2 identified in sEVs derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for SREBF2

Molecular Function     C-8 sterol isomerase activity GO:0000247 IDA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IMP     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA     DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA     protein binding GO:0005515 IPI     protein dimerization activity GO:0046983 IEA     E-box binding GO:0070888 IDA     sequence-specific double-stranded DNA binding GO:1990837 IDA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     regulation of transcription by RNA polymerase II GO:0006357 IDA     lipid metabolic process GO:0006629 TAS     cholesterol metabolic process GO:0008203 IEA     regulation of Notch signaling pathway GO:0008593 ISS     cellular response to starvation GO:0009267 IMP     positive regulation of cholesterol storage GO:0010886 IBA     positive regulation of cholesterol storage GO:0010886 IDA     SREBP signaling pathway GO:0032933 IDA     SREBP signaling pathway GO:0032933 IMP     cholesterol homeostasis GO:0042632 IEA     positive regulation of cholesterol biosynthetic process GO:0045542 IDA     positive regulation of cholesterol biosynthetic process GO:0045542 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 IBA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     cellular response to low-density lipoprotein particle stimulus GO:0071404 IEP     cellular response to laminar fluid shear stress GO:0071499 NAS     negative regulation of cholesterol efflux GO:0090370 IDA     regulation of mitophagy GO:1901524 HMP     positive regulation of miRNA transcription GO:1902895 IEA     positive regulation of protein targeting to mitochondrion GO:1903955 HMP Subcellular Localization     Golgi membrane GO:0000139 TAS     chromatin GO:0000785 ISA     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 IMP     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IDA     endoplasmic reticulum GO:0005783 IDA     endoplasmic reticulum membrane GO:0005789 TAS     cytosol GO:0005829 TAS     ER to Golgi transport vesicle membrane GO:0012507 IEA     SREBP-SCAP-Insig complex GO:0032937 IDA     intracellular membrane-bounded organelle GO:0043231 IDA