Gene description for SREBF1
Gene name	sterol regulatory element binding transcription factor 1
Gene symbol	SREBF1
Other names/aliases	SREBP-1c SREBP1 bHLHd1
Species	Homo sapiens
Database cross references - SREBF1
ExoCarta	ExoCarta_6720
Vesiclepedia	VP_6720
Entrez Gene	6720
HGNC	11289
MIM	184756
UniProt	P36956
SREBF1 identified in sEVs derived from the following tissue/cell type
Hepatocytes	26054723

Gene ontology annotations for SREBF1

Molecular Function     RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IDA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IMP     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA     transcription coregulator binding GO:0001221 IPI     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA     DNA binding GO:0003677 ISS     chromatin binding GO:0003682 IEA     DNA-binding transcription factor activity GO:0003700 IDA     nuclear receptor activity GO:0004879 IDA     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 IEA     sterol response element binding GO:0032810 IDA     protein-containing complex binding GO:0044877 IEA     protein dimerization activity GO:0046983 IEA     sequence-specific double-stranded DNA binding GO:1990837 IDA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IEA     regulation of heart rate by chemical signal GO:0003062 IEA     regulation of transcription by RNA polymerase II GO:0006357 IBA     regulation of transcription by RNA polymerase II GO:0006357 IDA     lipid metabolic process GO:0006629 TAS     cholesterol biosynthetic process GO:0006695 IEA     response to nutrient GO:0007584 IEA     circadian rhythm GO:0007623 IEA     insulin receptor signaling pathway GO:0008286 IEA     lipid biosynthetic process GO:0008610 IMP     lipid biosynthetic process GO:0008610 ISS     cellular response to starvation GO:0009267 ISS     response to xenobiotic stimulus GO:0009410 IEA     response to glucose GO:0009749 IEA     response to fructose GO:0009750 IEA     positive regulation of triglyceride biosynthetic process GO:0010867 ISS     regulation of lipid storage GO:0010883 IEA     regulation of fatty acid metabolic process GO:0019217 IEA     insulin secretion GO:0030073 IEA     lung development GO:0030324 IEA     intracellular receptor signaling pathway GO:0030522 IEA     regulation of protein stability GO:0031647 IMP     response to food GO:0032094 IEA     response to retinoic acid GO:0032526 IEA     response to progesterone GO:0032570 IEA     SREBP signaling pathway GO:0032933 IDA     SREBP signaling pathway GO:0032933 IMP     response to glucagon GO:0033762 IEA     mRNA transcription by RNA polymerase II GO:0042789 IEA     fat cell differentiation GO:0045444 IEA     response to ethanol GO:0045471 IEA     positive regulation of cholesterol biosynthetic process GO:0045542 IDA     positive regulation of cholesterol biosynthetic process GO:0045542 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IEA     positive regulation of transcription by RNA polymerase II GO:0045944 IGI     positive regulation of transcription by RNA polymerase II GO:0045944 TAS     negative regulation of insulin secretion GO:0046676 IEA     response to cAMP GO:0051591 IEA     cellular response to fatty acid GO:0071398 IEA     negative regulation of triglyceride metabolic process GO:0090209 IDA     regulation of mitophagy GO:1901524 IMP     positive regulation of miRNA transcription GO:1902895 IDA     regulation of protein targeting to mitochondrion GO:1903214 IMP Subcellular Localization     Golgi membrane GO:0000139 TAS     chromatin GO:0000785 ISA     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 IMP     nuclear envelope GO:0005635 TAS     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 ISS     endoplasmic reticulum GO:0005783 IDA     endoplasmic reticulum membrane GO:0005789 TAS     cytosol GO:0005829 TAS     ER to Golgi transport vesicle membrane GO:0012507 IEA     protein-containing complex GO:0032991 IEA