Gene description for SLC52A2
Gene name solute carrier family 52 (riboflavin transporter), member 2
Gene symbol SLC52A2
Other names/aliases BVVLS2
D15Ertd747e
GPCR41
GPR172A
PAR1
RFT3
RFVT2
hRFT3
Species Homo sapiens
 Database cross references - SLC52A2
ExoCarta ExoCarta_79581
Vesiclepedia VP_79581
Entrez Gene 79581
HGNC 30224
MIM 607882
UniProt Q9HAB3  
 SLC52A2 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 34887515    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SLC52A2
Molecular Function
    virus receptor activity GO:0001618 IEA
    protein binding GO:0005515 IPI
    riboflavin transmembrane transporter activity GO:0032217 IBA
    riboflavin transmembrane transporter activity GO:0032217 IDA
    riboflavin transmembrane transporter activity GO:0032217 TAS
    4-hydroxybutyrate receptor activity GO:0062124 IDA
Biological Process
    riboflavin metabolic process GO:0006771 TAS
    riboflavin transport GO:0032218 IBA
    riboflavin transport GO:0032218 IDA
    symbiont entry into host cell GO:0046718 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified SLC52A2 in sEVs
1
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
2
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SLC52A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LDLR 3949
Negative Genetic Homo sapiens
2 ADRB2  
PCA Homo sapiens
Two-hybrid Homo sapiens
3 FAM209A 200232
Two-hybrid Homo sapiens
4 FASN 2194
Negative Genetic Homo sapiens
5 UPK1A 11045
Affinity Capture-MS Homo sapiens
6 SREBF1 6720
Negative Genetic Homo sapiens
7 CDC23 8697
Two-hybrid Homo sapiens
8 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 CHRM2  
Two-hybrid Homo sapiens
10 GHITM 27069
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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