Gene description for CDC23
Gene name cell division cycle 23
Gene symbol CDC23
Other names/aliases ANAPC8
APC8
CUT23
Species Homo sapiens
 Database cross references - CDC23
ExoCarta ExoCarta_8697
Vesiclepedia VP_8697
Entrez Gene 8697
HGNC 1724
MIM 603462
UniProt Q9UJX2  
 CDC23 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
Prostate cancer cells 25844599    
Thymus 23844026    
 Gene ontology annotations for CDC23
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 TAS
    protein binding GO:0005515 IPI
Biological Process
    mitotic cell cycle GO:0000278 IDA
    ubiquitin-dependent protein catabolic process GO:0006511 TAS
    mitotic metaphase chromosome alignment GO:0007080 IDA
    metaphase/anaphase transition of mitotic cell cycle GO:0007091 TAS
    regulation of exit from mitosis GO:0007096 TAS
    regulation of mitotic cell cycle GO:0007346 NAS
    protein ubiquitination GO:0016567 IBA
    regulation of mitotic metaphase/anaphase transition GO:0030071 IDA
    anaphase-promoting complex-dependent catabolic process GO:0031145 IBA
    anaphase-promoting complex-dependent catabolic process GO:0031145 IDA
    anaphase-promoting complex-dependent catabolic process GO:0031145 NAS
    positive regulation of mitotic metaphase/anaphase transition GO:0045842 IBA
    cell division GO:0051301 IBA
    regulation of meiotic cell cycle GO:0051445 NAS
    protein K48-linked ubiquitination GO:0070936 IDA
    protein K11-linked ubiquitination GO:0070979 IDA
    protein branched polyubiquitination GO:0141198 IDA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    anaphase-promoting complex GO:0005680 IBA
    anaphase-promoting complex GO:0005680 IDA
    anaphase-promoting complex GO:0005680 IPI
    anaphase-promoting complex GO:0005680 NAS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified CDC23 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
12
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CDC23
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Two-hybrid Homo sapiens
2 GRAP2 9402
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CDC26 246184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 Cdk1 12534
Affinity Capture-MS Mus musculus
5 AP2B1 163
Proximity Label-MS Homo sapiens
6 ZFX  
Affinity Capture-MS Homo sapiens
7 Anapc13  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
8 CCDC24  
Two-hybrid Homo sapiens
9 RBPMS 11030
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
10 COIL  
Two-hybrid Homo sapiens
11 PAXIP1  
Affinity Capture-MS Homo sapiens
12 CCDC36  
Two-hybrid Homo sapiens
13 Anapc5 59008
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
14 RBM15B  
Two-hybrid Homo sapiens
15 Nek2  
Affinity Capture-MS Mus musculus
16 ANAPC5 51433
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 ANAPC15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 FAM9B  
Two-hybrid Homo sapiens
19 TAF3 83860
Co-fractionation Homo sapiens
20 BYSL 705
Two-hybrid Homo sapiens
21 Sirt2 64383
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
22 LAMTOR2 28956
Affinity Capture-MS Homo sapiens
23 CDC16 8881
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 EMILIN1 11117
Affinity Capture-Western Homo sapiens
25 CRACR2A  
Two-hybrid Homo sapiens
26 ZNF408  
Affinity Capture-MS Homo sapiens
27 DYRK1A 1859
Affinity Capture-MS Homo sapiens
28 DPYSL2 1808
Affinity Capture-MS Homo sapiens
29 CFAP97  
Affinity Capture-MS Homo sapiens
30 D2HGDH 728294
Affinity Capture-MS Homo sapiens
31 FZR1  
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 INPP5J  
Two-hybrid Homo sapiens
33 VKORC1 79001
Affinity Capture-MS Homo sapiens
34 SUV39H1  
Two-hybrid Homo sapiens
35 MDC1  
Affinity Capture-MS Homo sapiens
36 KLHL7  
Affinity Capture-MS Homo sapiens
37 FBL 2091
Affinity Capture-MS Homo sapiens
38 ANAPC11  
Co-purification Homo sapiens
39 TULP3 7289
Affinity Capture-MS Homo sapiens
40 CDC27 996
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 CDT1  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
42 ANAPC7 51434
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 YEATS2  
Affinity Capture-MS Homo sapiens
44 NAP1L4 4676
Co-fractionation Homo sapiens
45 FAM111A 63901
Affinity Capture-MS Homo sapiens
46 ANAPC16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 SOX5 6660
Two-hybrid Homo sapiens
48 MAD2L1 4085
Affinity Capture-MS Homo sapiens
49 Cdc20  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
50 FOXP3  
Affinity Capture-MS Homo sapiens
51 GPR17 2840
Affinity Capture-MS Homo sapiens
52 USP37  
Proximity Label-MS Homo sapiens
53 KIF14 9928
Affinity Capture-MS Homo sapiens
54 GPR156  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 Paxip1  
Affinity Capture-MS Mus musculus
56 USP22 23326
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
57 CEP44  
Two-hybrid Homo sapiens
58 PFN1 5216
Proximity Label-MS Homo sapiens
59 AURKA 6790
Affinity Capture-MS Homo sapiens
60 SLC52A2 79581
Two-hybrid Homo sapiens
61 MAPK3 5595
Two-hybrid Homo sapiens
62 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
63 CDC23 8697
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
64 PARK2  
Affinity Capture-MS Homo sapiens
65 CTBP1 1487
Two-hybrid Homo sapiens
66 RSL24D1  
Two-hybrid Homo sapiens
67 OPTN 10133
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
68 SLC39A9 55334
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 BCAS3 54828
Two-hybrid Homo sapiens
70 PNMA5 114824
Two-hybrid Homo sapiens
71 ZBTB48  
Affinity Capture-MS Homo sapiens
72 AKAP1 8165
Proximity Label-MS Homo sapiens
73 SP110  
Affinity Capture-MS Homo sapiens
74 C9orf72  
Affinity Capture-MS Homo sapiens
75 NEK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 BACE2 25825
Affinity Capture-MS Homo sapiens
77 SPERT  
Two-hybrid Homo sapiens
78 ANAPC10  
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 TTLL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 APOL1 8542
Two-hybrid Homo sapiens
81 HUWE1 10075
Affinity Capture-MS Homo sapiens
82 RPA4  
Proximity Label-MS Homo sapiens
83 HEMK1  
Two-hybrid Homo sapiens
84 ANAPC4 29945
Co-fractionation Homo sapiens
Co-purification Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 CRYL1 51084
Affinity Capture-MS Homo sapiens
86 LATS2 26524
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
87 CEBPA  
Proximity Label-MS Homo sapiens
88 FBXO5  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 UBXN6 80700
Affinity Capture-MS Homo sapiens
90 SSX2IP  
Two-hybrid Homo sapiens
91 UBE2S  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
92 ANAPC13 25847
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 ANO6 196527
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 COPS7A 50813
Affinity Capture-MS Homo sapiens
95 Cdc23  
Affinity Capture-MS Mus musculus
96 SMARCAD1  
Affinity Capture-MS Homo sapiens
97 TP53BP1 7158
Affinity Capture-MS Homo sapiens
98 XPO1 7514
Affinity Capture-MS Homo sapiens
99 SNAPC4  
Affinity Capture-MS Homo sapiens
100 NCAPH2  
Affinity Capture-MS Homo sapiens
101 Gm9174  
Affinity Capture-MS Mus musculus
102 CRYAB 1410
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 EDRF1  
Affinity Capture-MS Homo sapiens
104 PYCR1 5831
Affinity Capture-MS Homo sapiens
105 ATRIP  
Two-hybrid Homo sapiens
106 NAP1L1 4673
Co-fractionation Homo sapiens
107 PYCR2 29920
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 OCIAD1 54940
Affinity Capture-MS Homo sapiens
109 Anapc16  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
110 Cdc16  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
111 MTCH1 23787
Proximity Label-MS Homo sapiens
112 LZTS2 84445
Two-hybrid Homo sapiens
113 RRM2 6241
Affinity Capture-MS Homo sapiens
114 CUL9  
Affinity Capture-MS Homo sapiens
115 FBXO43  
Affinity Capture-Western Homo sapiens
116 CYB5R2 51700
Two-hybrid Homo sapiens
117 HECW2  
Affinity Capture-MS Homo sapiens
118 RAD54B  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
119 SCGN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 TRIM27  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
121 Anapc1  
Affinity Capture-MS Mus musculus
122 Bub1b 12236
Affinity Capture-MS Mus musculus
123 VWA8 23078
Affinity Capture-MS Homo sapiens
124 Mad2l1 56150
Affinity Capture-MS Mus musculus
125 PEX3 8504
Proximity Label-MS Homo sapiens
126 GORASP2 26003
Two-hybrid Homo sapiens
127 KIF2B 84643
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 TAF4 6874
Co-fractionation Homo sapiens
129 FHOD3  
Affinity Capture-MS Homo sapiens
130 CCDC8  
Affinity Capture-MS Homo sapiens
131 KCTD6  
Two-hybrid Homo sapiens
132 ZRANB1 54764
Affinity Capture-MS Homo sapiens
133 DEPDC1B 55789
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
134 Anapc2  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
135 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
136 PHB2 11331
Proximity Label-MS Homo sapiens
137 ANKFY1 51479
Proximity Label-MS Homo sapiens
138 CDC20 991
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 SIRT6  
Affinity Capture-MS Homo sapiens
140 SWSAP1  
Affinity Capture-MS Homo sapiens
141 NXF1 10482
Affinity Capture-RNA Homo sapiens
142 TRIM33 51592
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
143 MEN1 4221
Affinity Capture-MS Homo sapiens
144 BUB1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 SKP1 6500
Affinity Capture-MS Homo sapiens
146 EIF5A2 56648
Two-hybrid Homo sapiens
147 URB1 9875
Affinity Capture-MS Homo sapiens
148 ANAPC1 64682
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
149 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
150 BUB3 9184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 MKI67  
Affinity Capture-MS Homo sapiens
152 REPIN1  
Affinity Capture-MS Homo sapiens
153 MAGIX 79917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
154 ANAPC2 29882
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 KDM1A 23028
Two-hybrid Homo sapiens
156 PENK 5179
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
157 PSMA5 5686
Affinity Capture-MS Homo sapiens
158 AIFM1 9131
Proximity Label-MS Homo sapiens
159 C16orf72 29035
Affinity Capture-MS Homo sapiens
160 PXN 5829
Proximity Label-MS Homo sapiens
161 DLX6-AS1  
Two-hybrid Homo sapiens
162 TSC22D4 81628
Two-hybrid Homo sapiens
163 OSBPL5 114879
Affinity Capture-MS Homo sapiens
164 BRD1 23774
Affinity Capture-MS Homo sapiens
165 SNW1 22938
Affinity Capture-MS Homo sapiens
166 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
167 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
168 RAC1 5879
Two-hybrid Homo sapiens
169 INCA1  
Two-hybrid Homo sapiens
170 PHF8  
Affinity Capture-MS Homo sapiens
171 RPA3 6119
Proximity Label-MS Homo sapiens
172 C16orf87 388272
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
173 RPP38 10557
Affinity Capture-MS Homo sapiens
174 NOTCH1 4851
Affinity Capture-MS Homo sapiens
175 HIST1H2AE 3012
Affinity Capture-MS Homo sapiens
176 KIF18A  
Affinity Capture-MS Homo sapiens
177 CDC5L 988
Affinity Capture-MS Homo sapiens
178 Cdc26  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which CDC23 is involved
PathwayEvidenceSource
Aberrant regulation of mitotic cell cycle due to RB1 defects TAS Reactome
Aberrant regulation of mitotic exit in cancer due to RB1 defects TAS Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
Adaptive Immune System TAS Reactome
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome
APC-Cdc20 mediated degradation of Nek2A TAS Reactome
APC/C-mediated degradation of cell cycle proteins TAS Reactome
APC/C:Cdc20 mediated degradation of Cyclin B TAS Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins TAS Reactome
APC/C:Cdc20 mediated degradation of Securin TAS Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 TAS Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
Autodegradation of Cdh1 by Cdh1:APC/C TAS Reactome
Cdc20:Phospho-APC/C mediated degradation of Cyclin A TAS Reactome
CDK-mediated phosphorylation and removal of Cdc6 TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase TAS Reactome
Disease TAS Reactome
Diseases of mitotic cell cycle TAS Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
Immune System TAS Reactome
Inactivation of APC/C via direct inhibition of the APC/C complex TAS Reactome
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components TAS Reactome
M Phase TAS Reactome
Mitotic Anaphase TAS Reactome
Mitotic Metaphase and Anaphase TAS Reactome
Mitotic Spindle Checkpoint TAS Reactome
Phosphorylation of the APC/C TAS Reactome
Regulation of APC/C activators between G1/S and early anaphase TAS Reactome
Regulation of mitotic cell cycle TAS Reactome
RNA Polymerase II Transcription TAS Reactome
S Phase TAS Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Separation of Sister Chromatids TAS Reactome
Switching of origins to a post-replicative state TAS Reactome
Synthesis of DNA TAS Reactome
Transcriptional Regulation by VENTX TAS Reactome





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