Gene description for LDLR
Gene name low density lipoprotein receptor
Gene symbol LDLR
Other names/aliases FH
FHC
LDLCQ2
Species Homo sapiens
 Database cross references - LDLR
ExoCarta ExoCarta_3949
Vesiclepedia VP_3949
Entrez Gene 3949
HGNC 6547
MIM 606945
UniProt P01130  
 LDLR identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
T lymphocytes 34108659    
 Gene ontology annotations for LDLR
Molecular Function
    amyloid-beta binding GO:0001540 ISS
    virus receptor activity GO:0001618 IEA
    protease binding GO:0002020 IPI
    low-density lipoprotein particle receptor activity GO:0005041 IBA
    low-density lipoprotein particle receptor activity GO:0005041 IC
    low-density lipoprotein particle receptor activity GO:0005041 IDA
    low-density lipoprotein particle receptor activity GO:0005041 IMP
    low-density lipoprotein particle receptor activity GO:0005041 TAS
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    low-density lipoprotein particle binding GO:0030169 IMP
    very-low-density lipoprotein particle receptor activity GO:0030229 IDA
    clathrin heavy chain binding GO:0032050 TAS
    identical protein binding GO:0042802 IPI
    molecular adaptor activity GO:0060090 EXP
    lipoprotein particle binding GO:0071813 IBA
Biological Process
    negative regulation of receptor recycling GO:0001920 IDA
    lipid metabolic process GO:0006629 TAS
    endocytosis GO:0006897 TAS
    receptor-mediated endocytosis GO:0006898 ISS
    receptor-mediated endocytosis GO:0006898 TAS
    phagocytosis GO:0006909 ISS
    long-term memory GO:0007616 IGI
    cholesterol metabolic process GO:0008203 IEA
    positive regulation of gene expression GO:0010628 IEA
    negative regulation of gene expression GO:0010629 IEA
    positive regulation of triglyceride biosynthetic process GO:0010867 ISS
    regulation of phosphatidylcholine catabolic process GO:0010899 ISS
    negative regulation of low-density lipoprotein particle clearance GO:0010989 IDA
    phospholipid transport GO:0015914 ISS
    intestinal cholesterol absorption GO:0030299 IMP
    cholesterol transport GO:0030301 IMP
    cholesterol transport GO:0030301 TAS
    plasma lipoprotein particle clearance GO:0034381 ISS
    plasma lipoprotein particle clearance GO:0034381 TAS
    low-density lipoprotein particle clearance GO:0034383 IMP
    high-density lipoprotein particle clearance GO:0034384 IEA
    lipoprotein catabolic process GO:0042159 IEA
    cholesterol homeostasis GO:0042632 IBA
    cholesterol homeostasis GO:0042632 IGI
    cholesterol homeostasis GO:0042632 IMP
    cholesterol homeostasis GO:0042632 TAS
    symbiont entry into host cell GO:0046718 IEA
    artery morphogenesis GO:0048844 IEA
    positive regulation of inflammatory response GO:0050729 IEA
    regulation of protein metabolic process GO:0051246 IGI
    negative regulation of protein metabolic process GO:0051248 ISS
    response to caloric restriction GO:0061771 IGI
    negative regulation of astrocyte activation GO:0061889 ISS
    cholesterol import GO:0070508 IMP
    cholesterol import GO:0070508 ISS
    cellular response to fatty acid GO:0071398 IEA
    cellular response to low-density lipoprotein particle stimulus GO:0071404 IMP
    receptor-mediated endocytosis involved in cholesterol transport GO:0090118 IBA
    receptor-mediated endocytosis involved in cholesterol transport GO:0090118 IMP
    regulation of cholesterol metabolic process GO:0090181 IEA
    amyloid-beta clearance GO:0097242 ISS
    amyloid-beta clearance by cellular catabolic process GO:0150094 ISS
    negative regulation of microglial cell activation GO:1903979 ISS
    positive regulation of lysosomal protein catabolic process GO:1905167 ISS
    negative regulation of amyloid fibril formation GO:1905907 ISS
Subcellular Localization
    lysosome GO:0005764 IDA
    early endosome GO:0005769 IBA
    early endosome GO:0005769 IDA
    late endosome GO:0005770 IDA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    clathrin-coated pit GO:0005905 IDA
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISS
    endosome membrane GO:0010008 TAS
    membrane GO:0016020 HDA
    basolateral plasma membrane GO:0016323 ISS
    clathrin-coated endocytic vesicle membrane GO:0030669 TAS
    low-density lipoprotein particle GO:0034362 IEA
    endolysosome membrane GO:0036020 TAS
    somatodendritic compartment GO:0036477 IEA
    receptor complex GO:0043235 IDA
    apical part of cell GO:0045177 ISS
    sorting endosome GO:0097443 IEA
    PCSK9-LDLR complex GO:1990666 IDA
    PCSK9-LDLR complex GO:1990666 IPI
 Experiment description of studies that identified LDLR in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
10
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
11
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
12
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
13
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
17
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
18
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
19
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
23
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
24
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
26
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
28
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
29
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
30
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
31
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
32
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
33
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
34
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
35
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
36
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
37
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
38
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for LDLR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EIF2AK4 440275
Positive Genetic Homo sapiens
2 MYLIP  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Protein-peptide Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 ATG9A 79065
Negative Genetic Homo sapiens
4 MRPL33  
Positive Genetic Homo sapiens
5 NRSN1  
Affinity Capture-MS Homo sapiens
6 AES 166
Two-hybrid Homo sapiens
7 ALG12  
Negative Genetic Homo sapiens
8 LIMS1 3987
Negative Genetic Homo sapiens
9 MAP4 4134
Two-hybrid Homo sapiens
10 SLC25A1 6576
Negative Genetic Homo sapiens
11 KPNA2 3838
Negative Genetic Homo sapiens
12 GLCE 26035
Negative Genetic Homo sapiens
13 GCN1L1 10985
Positive Genetic Homo sapiens
14 FAM109B  
Negative Genetic Homo sapiens
15 HDAC3 8841
Negative Genetic Homo sapiens
16 SMG9 56006
Positive Genetic Homo sapiens
17 MTF2  
Negative Genetic Homo sapiens
18 TRMU  
Negative Genetic Homo sapiens
19 CHAF1A  
Positive Genetic Homo sapiens
20 MON2 23041
Negative Genetic Homo sapiens
21 MBTD1  
Negative Genetic Homo sapiens
22 CPSF7 79869
Positive Genetic Homo sapiens
23 ST14 6768
Affinity Capture-MS Homo sapiens
24 SQLE 6713
Negative Genetic Homo sapiens
25 LIPG 9388
Affinity Capture-MS Homo sapiens
26 LAMTOR4 389541
Positive Genetic Homo sapiens
27 PREPL 9581
Negative Genetic Homo sapiens
28 AGO2 27161
Positive Genetic Homo sapiens
29 HEXIM1 10614
Negative Genetic Homo sapiens
30 PREX2  
Negative Genetic Homo sapiens
31 ZNF415  
Negative Genetic Homo sapiens
32 OSGEPL1  
Negative Genetic Homo sapiens
33 UBE4B 10277
Positive Genetic Homo sapiens
34 C12orf40  
Negative Genetic Homo sapiens
35 USP14 9097
Positive Genetic Homo sapiens
36 OR56A4  
Negative Genetic Homo sapiens
37 PELO 53918
Positive Genetic Homo sapiens
38 ANKRD17 26057
Positive Genetic Homo sapiens
39 FAM122A  
Positive Genetic Homo sapiens
40 NPAP1  
Positive Genetic Homo sapiens
41 MTF1  
Negative Genetic Homo sapiens
42 C12orf49  
Negative Genetic Homo sapiens
43 CARM1 10498
Positive Genetic Homo sapiens
44 ZFP41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PSMD2 5708
Positive Genetic Homo sapiens
46 MYH9 4627
Negative Genetic Homo sapiens
47 CYBA 1535
Positive Genetic Homo sapiens
48 EGFL6 25975
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 P4HB 5034
Negative Genetic Homo sapiens
50 PF4 5196
Reconstituted Complex Homo sapiens
51 STH  
Negative Genetic Homo sapiens
52 BBC3  
Negative Genetic Homo sapiens
53 PHLPP1  
Positive Genetic Homo sapiens
54 BRD7  
Positive Genetic Homo sapiens
55 HSPA5 3309
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Negative Genetic Homo sapiens
56 HTRA2 27429
Positive Genetic Homo sapiens
57 TFEC  
Positive Genetic Homo sapiens
58 CUL3 8452
Affinity Capture-MS Homo sapiens
59 HSPA14 51182
Positive Genetic Homo sapiens
60 VARS2  
Negative Genetic Homo sapiens
61 SIN3B  
Positive Genetic Homo sapiens
62 ATMIN  
Positive Genetic Homo sapiens
63 MPC1 51660
Negative Genetic Homo sapiens
64 STRAP 11171
Positive Genetic Homo sapiens
65 SNAPC2  
Negative Genetic Homo sapiens
66 MBTPS2  
Negative Genetic Homo sapiens
67 SNX17 9784
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
68 ROMO1 140823
Positive Genetic Homo sapiens
69 AP1M2 10053
Affinity Capture-Western Homo sapiens
70 LCMT1 51451
Negative Genetic Homo sapiens
71 C9orf153  
Positive Genetic Homo sapiens
72 DLAT 1737
Negative Genetic Homo sapiens
73 KIAA1257  
Positive Genetic Homo sapiens
74 EIF4E2  
Negative Genetic Homo sapiens
75 MESDC1  
Positive Genetic Homo sapiens
76 CDC25A  
Positive Genetic Homo sapiens
77 HMGCR  
Negative Genetic Homo sapiens
78 FASN 2194
Negative Genetic Homo sapiens
Negative Genetic Homo sapiens
79 CLPX 10845
Negative Genetic Homo sapiens
80 DAB2 1601
Reconstituted Complex Homo sapiens
81 GSS 2937
Positive Genetic Homo sapiens
82 CDK8 1024
Positive Genetic Homo sapiens
83 FCGRT 2217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 CD1B 910
Affinity Capture-MS Homo sapiens
85 LDHB 3945
Negative Genetic Homo sapiens
86 TBL3 10607
Positive Genetic Homo sapiens
87 PAPOLG  
Negative Genetic Homo sapiens
88 NCR3  
Affinity Capture-MS Homo sapiens
89 SIRT1  
Positive Genetic Homo sapiens
90 ARL14  
Positive Genetic Homo sapiens
91 FLCN 201163
Positive Genetic Homo sapiens
92 EPHA6 285220
Negative Genetic Homo sapiens
93 BCL2  
Positive Genetic Homo sapiens
94 RIC8A 60626
Negative Genetic Homo sapiens
95 ACO2 50
Negative Genetic Homo sapiens
96 POLA1  
Negative Genetic Homo sapiens
97 SNW1 22938
Positive Genetic Homo sapiens
98 P2RX2  
Affinity Capture-MS Homo sapiens
99 GATAD1  
Positive Genetic Homo sapiens
100 POLE3  
Negative Genetic Homo sapiens
101 GREM2 64388
Affinity Capture-MS Homo sapiens
102 EPC2  
Positive Genetic Homo sapiens
103 MORC2  
Negative Genetic Homo sapiens
104 KPNA3 3839
Negative Genetic Homo sapiens
105 SACM1L 22908
Negative Genetic Homo sapiens
106 KLK5 25818
Affinity Capture-MS Homo sapiens
107 FSTL4  
Affinity Capture-MS Homo sapiens
108 KIAA0020 9933
Positive Genetic Homo sapiens
109 SPTLC1 10558
Negative Genetic Homo sapiens
110 LGALS1 3956
Affinity Capture-MS Homo sapiens
111 USP16  
Positive Genetic Homo sapiens
112 RPL14 9045
Positive Genetic Homo sapiens
113 PUS3  
Negative Genetic Homo sapiens
114 SNRPF 6636
Negative Genetic Homo sapiens
115 FFAR1  
Affinity Capture-MS Homo sapiens
116 NDUFS2 4720
Positive Genetic Homo sapiens
117 SLC16A10 117247
Positive Genetic Homo sapiens
118 MFAP5  
Affinity Capture-MS Homo sapiens
119 YTHDF2 51441
Negative Genetic Homo sapiens
120 SAFB 6294
Negative Genetic Homo sapiens
121 PPTC7 160760
Negative Genetic Homo sapiens
122 B3GNT2 10678
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 TRMT44  
Negative Genetic Homo sapiens
124 ARID4B  
Positive Genetic Homo sapiens
125 STIP1 10963
Positive Genetic Homo sapiens
126 TMEM192 201931
Affinity Capture-MS Homo sapiens
127 MSL2  
Negative Genetic Homo sapiens
128 TRMT1 55621
Positive Genetic Homo sapiens
129 DEFA1 1667
Affinity Capture-MS Homo sapiens
130 SLC25A10 1468
Positive Genetic Homo sapiens
131 HNRNPA0 10949
Positive Genetic Homo sapiens
132 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
133 USP10 9100
Positive Genetic Homo sapiens
134 RBX1 9978
Positive Genetic Homo sapiens
135 IGSF5  
Affinity Capture-MS Homo sapiens
136 GOLGA8G  
Affinity Capture-MS Homo sapiens
137 BAG6 7917
Negative Genetic Homo sapiens
138 POLA2  
Negative Genetic Homo sapiens
139 FAM193A  
Positive Genetic Homo sapiens
140 CBR3 874
Affinity Capture-MS Homo sapiens
141 CMA1  
Affinity Capture-MS Homo sapiens
142 SNRPD1 6632
Negative Genetic Homo sapiens
143 ABHD11 83451
Positive Genetic Homo sapiens
144 MRPL51 51258
Negative Genetic Homo sapiens
145 PLK1 5347
Negative Genetic Homo sapiens
146 CNFN  
Positive Genetic Homo sapiens
147 CCDC101  
Positive Genetic Homo sapiens
148 FAM19A2 338811
Affinity Capture-MS Homo sapiens
149 UST  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 GPS2  
Negative Genetic Homo sapiens
151 RECQL5  
Negative Genetic Homo sapiens
152 PTPN11 5781
Negative Genetic Homo sapiens
153 SLC26A2 1836
Positive Genetic Homo sapiens
154 CANX 821
Affinity Capture-Western Homo sapiens
155 MTIF3  
Two-hybrid Homo sapiens
156 MEX3A  
Affinity Capture-RNA Homo sapiens
157 BRD8 10902
Positive Genetic Homo sapiens
158 PRG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
159 Oxnad1  
Affinity Capture-MS Mus musculus
160 DEFB123  
Affinity Capture-MS Homo sapiens
161 GINS3  
Positive Genetic Homo sapiens
162 DEFB136  
Affinity Capture-MS Homo sapiens
163 ASNSD1  
Negative Genetic Homo sapiens
164 ZDHHC18 84243
Positive Genetic Homo sapiens
165 SART3 9733
Positive Genetic Homo sapiens
166 KIAA0895L  
Positive Genetic Homo sapiens
167 PNPO 55163
Positive Genetic Homo sapiens
168 NXPH3  
Negative Genetic Homo sapiens
169 WISP3  
Affinity Capture-MS Homo sapiens
170 TADA2B  
Positive Genetic Homo sapiens
171 RAB18 22931
Positive Genetic Homo sapiens
172 EMC6 83460
Negative Genetic Homo sapiens
173 CS 1431
Negative Genetic Homo sapiens
174 KIF21B 23046
Positive Genetic Homo sapiens
175 SPOP  
Positive Genetic Homo sapiens
176 PARP1 142
Negative Genetic Homo sapiens
177 MAX  
Positive Genetic Homo sapiens
178 UBA5 79876
Negative Genetic Homo sapiens
179 FXR1 8087
Negative Genetic Homo sapiens
180 SLC39A7 7922
Affinity Capture-MS Homo sapiens
181 KEAP1 9817
Negative Genetic Homo sapiens
182 MSMO1 6307
Negative Genetic Homo sapiens
183 NSDHL 50814
Negative Genetic Homo sapiens
184 MGAT4C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
185 EPC1  
Positive Genetic Homo sapiens
186 LSS 4047
Negative Genetic Homo sapiens
187 SETD1B 23067
Positive Genetic Homo sapiens
188 EDDM3A  
Positive Genetic Homo sapiens
189 NTN5  
Affinity Capture-MS Homo sapiens
190 BRD1 23774
Affinity Capture-MS Homo sapiens
191 KIR2DL4  
Affinity Capture-MS Homo sapiens
192 NRARP  
Positive Genetic Homo sapiens
193 IMP4  
Positive Genetic Homo sapiens
194 AEBP2  
Positive Genetic Homo sapiens
195 YBEY  
Positive Genetic Homo sapiens
196 KDM5C  
Negative Genetic Homo sapiens
197 SLFN11 91607
Positive Genetic Homo sapiens
198 NDUFS1 4719
Positive Genetic Homo sapiens
199 THRB 7068
Negative Genetic Homo sapiens
200 RANBP3 8498
Positive Genetic Homo sapiens
201 CBLL1  
Negative Genetic Homo sapiens
202 MNT  
Positive Genetic Homo sapiens
203 SAMD1  
Positive Genetic Homo sapiens
204 MANF 7873
Negative Genetic Homo sapiens
205 SLURP1  
Affinity Capture-MS Homo sapiens
206 DIMT1 27292
Positive Genetic Homo sapiens
207 RPL10A 4736
Negative Genetic Homo sapiens
208 WDR48 57599
Positive Genetic Homo sapiens
209 C11orf30  
Positive Genetic Homo sapiens
210 TIMMDC1  
Positive Genetic Homo sapiens
211 ING3  
Positive Genetic Homo sapiens
212 RAB11FIP3  
Positive Genetic Homo sapiens
213 IGFL3  
Affinity Capture-MS Homo sapiens
214 CLTC 1213
Negative Genetic Homo sapiens
215 TMEM106A  
Affinity Capture-MS Homo sapiens
216 CSK 1445
Negative Genetic Homo sapiens
217 NCOA1  
Positive Genetic Homo sapiens
218 TRRAP 8295
Positive Genetic Homo sapiens
219 CHD1 1105
Negative Genetic Homo sapiens
220 SLC52A2 79581
Negative Genetic Homo sapiens
221 AP5S1  
Negative Genetic Homo sapiens
222 NSUN2 54888
Positive Genetic Homo sapiens
223 ACAT2 39
Negative Genetic Homo sapiens
224 PTPRN2  
Positive Genetic Homo sapiens
225 HMGCS1 3157
Negative Genetic Homo sapiens
226 TMEM165 55858
Negative Genetic Homo sapiens
227 NOP2 4839
Positive Genetic Homo sapiens
228 KPNA4 3840
Negative Genetic Homo sapiens
229 MST1 4485
Negative Genetic Homo sapiens
230 BCL2L2 599
Positive Genetic Homo sapiens
231 LDLRAP1 26119
Reconstituted Complex Homo sapiens
232 RPLP1 6176
Positive Genetic Homo sapiens
233 UBA3 9039
Positive Genetic Homo sapiens
234 PHF12  
Positive Genetic Homo sapiens
235 PELP1 27043
Positive Genetic Homo sapiens
236 UROS 7390
Negative Genetic Homo sapiens
237 TMEM121  
Positive Genetic Homo sapiens
238 ACTG1 71
Positive Genetic Homo sapiens
239 BZW1 9689
Positive Genetic Homo sapiens
240 OLA1 29789
Positive Genetic Homo sapiens
241 CCNA2 890
Positive Genetic Homo sapiens
242 KATNBL1  
Affinity Capture-MS Homo sapiens
243 KMT2A  
Positive Genetic Homo sapiens
244 MYH8 4626
Negative Genetic Homo sapiens
245 HSD17B7 51478
Negative Genetic Homo sapiens
246 MASP1 5648
Positive Genetic Homo sapiens
247 CHCHD1  
Negative Genetic Homo sapiens
248 SMARCD1 6602
Positive Genetic Homo sapiens
249 SMG8 55181
Positive Genetic Homo sapiens
250 FAM60A  
Positive Genetic Homo sapiens
251 CDK5RAP1  
Negative Genetic Homo sapiens
252 METTL16 79066
Negative Genetic Homo sapiens
253 E2F7  
Negative Genetic Homo sapiens
254 LYZL1  
Affinity Capture-MS Homo sapiens
255 FBXO6 26270
Affinity Capture-MS Homo sapiens
256 HNRNPUL1 11100
Negative Genetic Homo sapiens
257 LAMTOR5 10542
Positive Genetic Homo sapiens
258 DNAJC10 54431
Affinity Capture-MS Homo sapiens
259 C1D  
Positive Genetic Homo sapiens
260 NEUROG3  
Positive Genetic Homo sapiens
261 ALG9 79796
Negative Genetic Homo sapiens
262 MTHFD2 10797
Positive Genetic Homo sapiens
263 FOXO3  
Negative Genetic Homo sapiens
264 SOD2 6648
Positive Genetic Homo sapiens
265 GPI 2821
Negative Genetic Homo sapiens
266 SLC26A6 65010
Negative Genetic Homo sapiens
267 PDHA1 5160
Negative Genetic Homo sapiens
268 NKTR  
Positive Genetic Homo sapiens
269 CREBBP  
Biochemical Activity Homo sapiens
270 PDIA4 9601
Affinity Capture-Western Homo sapiens
271 CLVS2 134829
Positive Genetic Homo sapiens
272 BABAM1 29086
Negative Genetic Homo sapiens
273 MIF 4282
Negative Genetic Homo sapiens
274 THRA  
Positive Genetic Homo sapiens
275 TRIM37  
Proximity Label-MS Homo sapiens
276 RPL38 6169
Positive Genetic Homo sapiens
277 NFYB  
Positive Genetic Homo sapiens
278 OXGR1  
Positive Genetic Homo sapiens
279 NDUFAF6  
Positive Genetic Homo sapiens
280 SERBP1 26135
Positive Genetic Homo sapiens
281 EDN3  
Affinity Capture-MS Homo sapiens
282 GTPBP2 54676
Negative Genetic Homo sapiens
283 ZCWPW1 55063
Negative Genetic Homo sapiens
284 INSIG1  
Negative Genetic Homo sapiens
285 WBP1L  
Negative Genetic Homo sapiens
286 RIT1 6016
Negative Genetic Homo sapiens
287 VPS35 55737
Positive Genetic Homo sapiens
288 ZNF292  
Positive Genetic Homo sapiens
289 OTUD5 55593
Negative Genetic Homo sapiens
290 MCM8 84515
Negative Genetic Homo sapiens
291 KLK15  
Affinity Capture-MS Homo sapiens
292 RPS3A 6189
Positive Genetic Homo sapiens
293 CPOX 1371
Negative Genetic Homo sapiens
294 TNPO1 3842
Positive Genetic Homo sapiens
295 DLK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
296 WNT7A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
297 TIMM22  
Negative Genetic Homo sapiens
298 ECEL1  
Affinity Capture-MS Homo sapiens
299 DAB1 1600
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
300 USP9X 8239
Negative Genetic Homo sapiens
301 PTP4A1 7803
Positive Genetic Homo sapiens
302 SAP30 8819
Positive Genetic Homo sapiens
303 PDHB 5162
Negative Genetic Homo sapiens
304 KDM4A  
Positive Genetic Homo sapiens
305 CAPRIN1 4076
Negative Genetic Homo sapiens
306 KIAA1429 25962
Negative Genetic Homo sapiens
307 RNH1 6050
Negative Genetic Homo sapiens
308 MEIS2  
Positive Genetic Homo sapiens
309 ALG3 10195
Negative Genetic Homo sapiens
310 HLA-DRB3 3125
Affinity Capture-MS Homo sapiens
311 ZNF408  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
312 CDK14 5218
Negative Genetic Homo sapiens
313 SP3  
Positive Genetic Homo sapiens
314 WDR20 91833
Positive Genetic Homo sapiens
315 USP3 9960
Negative Genetic Homo sapiens
316 GINM1 116254
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
317 RER1 11079
Positive Genetic Homo sapiens
318 CYP3A5  
Negative Genetic Homo sapiens
319 FOXD4L6  
Affinity Capture-MS Homo sapiens
320 DBX1  
Positive Genetic Homo sapiens
321 EED  
Negative Genetic Homo sapiens
322 PRG3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
323 ASH2L 9070
Positive Genetic Homo sapiens
324 USP2  
Affinity Capture-Western Homo sapiens
325 SSR3 6747
Negative Genetic Homo sapiens
326 SFXN1 94081
Positive Genetic Homo sapiens
327 DENND5B  
Negative Genetic Homo sapiens
328 E2F4  
Positive Genetic Homo sapiens
329 WNT3A 89780
Affinity Capture-MS Homo sapiens
330 INPP4A 3631
Negative Genetic Homo sapiens
331 HAUS2  
Negative Genetic Homo sapiens
332 COX15 1355
Positive Genetic Homo sapiens
333 SAR1A 56681
Negative Genetic Homo sapiens
334 HSP90B1 7184
Affinity Capture-Western Homo sapiens
335 GNB5 10681
Positive Genetic Homo sapiens
336 FAM19A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
337 SREBF2 6721
Negative Genetic Homo sapiens
Negative Genetic Homo sapiens
338 MLX  
Negative Genetic Homo sapiens
339 DNAJB9 4189
Negative Genetic Homo sapiens
340 BRICD5  
Affinity Capture-MS Homo sapiens
341 PCSK9 255738
Affinity Capture-Western Homo sapiens
342 MYH10 4628
Negative Genetic Homo sapiens
343 FIBP 9158
Negative Genetic Homo sapiens
344 WNT10A  
Affinity Capture-MS Homo sapiens
345 SUDS3  
Positive Genetic Homo sapiens
346 TMPRSS13  
Affinity Capture-MS Homo sapiens
347 ARID4A  
Positive Genetic Homo sapiens
348 C22orf39  
Negative Genetic Homo sapiens
349 ACSM1 116285
Positive Genetic Homo sapiens
350 MAGEB17 645864
Positive Genetic Homo sapiens
351 ELAVL2 1993
Positive Genetic Homo sapiens
352 DDX59 83479
Negative Genetic Homo sapiens
353 IPO5 3843
Positive Genetic Homo sapiens
354 RPLP2 6181
Positive Genetic Homo sapiens
355 C14orf1 11161
Negative Genetic Homo sapiens
356 SERF2 10169
Negative Genetic Homo sapiens
357 CCDC120  
Negative Genetic Homo sapiens
358 PI15  
Affinity Capture-MS Homo sapiens
359 XAB2 56949
Positive Genetic Homo sapiens
360 TYW3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
361 PDIA3 2923
Affinity Capture-MS Homo sapiens
362 XPNPEP3 63929
Negative Genetic Homo sapiens
363 SLC25A36  
Positive Genetic Homo sapiens
364 FDFT1 2222
Negative Genetic Homo sapiens
365 SF3A1 10291
Negative Genetic Homo sapiens
366 CTSG 1511
Affinity Capture-MS Homo sapiens
367 EXT1 2131
Negative Genetic Homo sapiens
368 PADI3 51702
Positive Genetic Homo sapiens
369 FCHO2 115548
Negative Genetic Homo sapiens
370 ZNF486 90649
Negative Genetic Homo sapiens
371 SCRN2 90507
Positive Genetic Homo sapiens
372 REG3G  
Negative Genetic Homo sapiens
373 ATF4  
Positive Genetic Homo sapiens
374 ADAM30 11085
Affinity Capture-MS Homo sapiens
375 KAT2A  
Positive Genetic Homo sapiens
376 SRRM1 10250
Negative Genetic Homo sapiens
377 SNAPC3  
Negative Genetic Homo sapiens
378 POLR2L 5441
Negative Genetic Homo sapiens
379 CCDC178  
Positive Genetic Homo sapiens
380 SMURF1 57154
Positive Genetic Homo sapiens
381 ELAVL1 1994
Positive Genetic Homo sapiens
382 CREB1  
Positive Genetic Homo sapiens
383 DOLPP1  
Negative Genetic Homo sapiens
384 CD36 948
Reconstituted Complex Homo sapiens
385 LRPAP1 4043
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
386 TMEM126B 55863
Negative Genetic Homo sapiens
387 EZH2  
Negative Genetic Homo sapiens
388 ZNF106  
Negative Genetic Homo sapiens
389 ZNF629 23361
Positive Genetic Homo sapiens
390 ELF2  
Positive Genetic Homo sapiens
391 OAZ1 4946
Negative Genetic Homo sapiens
392 GNB2L1 10399
Positive Genetic Homo sapiens
393 N6AMT2 221143
Positive Genetic Homo sapiens
394 TIMP3 7078
Affinity Capture-MS Homo sapiens
395 CXCL16 58191
Affinity Capture-MS Homo sapiens
396 PARN  
Positive Genetic Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here