Gene description for HSD17B7
Gene name hydroxysteroid (17-beta) dehydrogenase 7
Gene symbol HSD17B7
Other names/aliases PRAP
SDR37C1
Species Homo sapiens
 Database cross references - HSD17B7
ExoCarta ExoCarta_51478
Vesiclepedia VP_51478
Entrez Gene 51478
HGNC 5215
MIM 606756
UniProt P56937  
 HSD17B7 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for HSD17B7
Molecular Function
    3-keto sterol reductase activity GO:0000253 IBA
    3-keto sterol reductase activity GO:0000253 IDA
    3-keto sterol reductase activity GO:0000253 TAS
    estradiol 17-beta-dehydrogenase [NAD(P)+] activity GO:0004303 IBA
    estradiol 17-beta-dehydrogenase [NAD(P)+] activity GO:0004303 IDA
    5alpha-androstane-3beta,17beta-diol dehydrogenase activity GO:0047024 IBA
    5alpha-androstane-3beta,17beta-diol dehydrogenase activity GO:0047024 IDA
Biological Process
    cholesterol biosynthetic process GO:0006695 IBA
    cholesterol biosynthetic process GO:0006695 IDA
    cholesterol biosynthetic process GO:0006695 TAS
    estrogen biosynthetic process GO:0006703 IDA
    estrogen biosynthetic process GO:0006703 IEA
    androgen metabolic process GO:0008209 IDA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified HSD17B7 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HSD17B7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC37A3  
Affinity Capture-MS Homo sapiens
2 MAGEA8  
Affinity Capture-MS Homo sapiens
3 SLC39A12  
Affinity Capture-MS Homo sapiens
4 SV2A 9900
Affinity Capture-MS Homo sapiens
5 TFDP3  
Affinity Capture-MS Homo sapiens
6 SLC18A1  
Affinity Capture-MS Homo sapiens
7 DDI1  
Affinity Capture-MS Homo sapiens
8 LCN6  
Affinity Capture-MS Homo sapiens
9 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
10 CA1 759
Two-hybrid Homo sapiens
11 E2F4  
Affinity Capture-MS Homo sapiens
12 IGHM 3507
Affinity Capture-MS Homo sapiens
13 BRSK1  
Two-hybrid Homo sapiens
14 SLC1A5 6510
Affinity Capture-MS Homo sapiens
15 PCK2 5106
Co-fractionation Homo sapiens
16 RYR3 6263
Cross-Linking-MS (XL-MS) Homo sapiens
17 SLAMF1 6504
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 DTYMK 1841
Two-hybrid Homo sapiens
19 GORAB 92344
Two-hybrid Homo sapiens
20 SLC18A2  
Affinity Capture-MS Homo sapiens
21 ACP5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 CCS 9973
Co-fractionation Homo sapiens
23 ORAI1 84876
Affinity Capture-MS Homo sapiens
24 AGPAT6 137964
Two-hybrid Homo sapiens
25 LDLR 3949
Negative Genetic Homo sapiens
26 VKORC1 79001
Two-hybrid Homo sapiens
27 GLMP 112770
Affinity Capture-MS Homo sapiens
28 P2RY10  
Affinity Capture-MS Homo sapiens
29 POLB 5423
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SLC22A4 6583
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HSD17B7 is involved
PathwayEvidenceSource
Cholesterol biosynthesis TAS Reactome
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Metabolism of steroids TAS Reactome





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