Gene description for GLMP
Gene name glycosylated lysosomal membrane protein
Gene symbol GLMP
Other names/aliases C1orf85
NCU-G1
Species Homo sapiens
 Database cross references - GLMP
ExoCarta ExoCarta_112770
Vesiclepedia VP_112770
Entrez Gene 112770
HGNC 29436
UniProt Q8WWB7  
 GLMP identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for GLMP
Biological Process
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    protein stabilization GO:0050821 ISS
    protein localization to lysosome GO:0061462 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    lysosome GO:0005764 IBA
    lysosome GO:0005764 IDA
    lysosomal membrane GO:0005765 IEA
    cytosol GO:0005829 IDA
    membrane GO:0016020 ISS
 Experiment description of studies that identified GLMP in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GLMP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DEPDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 GNAZ 2781
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 TFB2M  
Affinity Capture-MS Homo sapiens
4 C5AR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SLC25A24 29957
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 VDR  
Affinity Capture-MS Homo sapiens
7 PEX16 9409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TUBB 203068
Affinity Capture-MS Homo sapiens
9 ST14 6768
Affinity Capture-MS Homo sapiens
10 CLN3 1201
Affinity Capture-MS Homo sapiens
11 TUBB2A 7280
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SLC25A6 293
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 HEATR6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TIMM17A  
Affinity Capture-MS Homo sapiens
15 BDH1 622
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 SLC25A29  
Affinity Capture-MS Homo sapiens
17 SLC25A33  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 HSD17B7 51478
Affinity Capture-MS Homo sapiens
19 SLC25A30 253512
Affinity Capture-MS Homo sapiens
20 PARL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 DHRS9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 TUBB4B 10383
Affinity Capture-MS Homo sapiens
23 MTX1 4580
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 DDX19B 11269
Affinity Capture-MS Homo sapiens
25 LARS2 23395
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 NR2F1  
Affinity Capture-MS Homo sapiens
27 SLC25A5 292
Affinity Capture-MS Homo sapiens
28 TRUB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 SERPINB13 5275
Affinity Capture-MS Homo sapiens
30 TUBB8 347688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 MTG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 ATP12A 479
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CDC6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 TUBB3 10381
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 INTS8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 SLC25A15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 ALDH5A1 7915
Affinity Capture-MS Homo sapiens
38 GPD1L 23171
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 C17orf75 64149
Affinity Capture-MS Homo sapiens
40 CHD1L 9557
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 TTK 7272
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 FAM69A 388650
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 SFXN3 81855
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 TUBB1 81027
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 XRN1 54464
Two-hybrid Homo sapiens
46 TUBA1A 7846
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 PRKAG1 5571
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 C17orf80 55028
Affinity Capture-MS Homo sapiens
49 LRP1 4035
Affinity Capture-MS Homo sapiens
50 TUBA4A 7277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 CDYL 9425
Affinity Capture-MS Homo sapiens
52 IDH2 3418
Affinity Capture-MS Homo sapiens
53 SLC25A20 788
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 C4orf29 80167
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 FAM118B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 FDXR 2232
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 SLC25A4 291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 SFXN5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 SYNJ2BP 55333
Co-fractionation Homo sapiens
60 ADCK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 MDN1 23195
Affinity Capture-MS Homo sapiens
62 NEK4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 DECR2 26063
Affinity Capture-MS Homo sapiens
64 NCLN 56926
Affinity Capture-MS Homo sapiens
65 NR2F2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 TMEM126B 55863
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 TIMM23 100287932
Affinity Capture-MS Homo sapiens
68 STX7 8417
Affinity Capture-MS Homo sapiens
69 TUBA1C 84790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 XRCC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 ABHD17B 51104
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 LGALS8 3964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 FAM127A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 HSPA12A 259217
Affinity Capture-MS Homo sapiens
75 INTS5 80789
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 RPP38 10557
Affinity Capture-MS Homo sapiens
77 SLC25A14  
Affinity Capture-MS Homo sapiens
78 APOOL 139322
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 TUBB4A 10382
Affinity Capture-MS Homo sapiens
80 NFXL1 152518
Affinity Capture-MS Homo sapiens
81 VMP1 81671
Affinity Capture-MS Homo sapiens
82 VDAC3 7419
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which GLMP is involved
No pathways found





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