Gene description for SLC25A10
Gene name solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
Gene symbol SLC25A10
Other names/aliases DIC
Species Homo sapiens
 Database cross references - SLC25A10
ExoCarta ExoCarta_1468
Vesiclepedia VP_1468
Entrez Gene 1468
HGNC 10980
MIM 606794
UniProt Q9UBX3  
 SLC25A10 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for SLC25A10
Molecular Function
    dicarboxylic acid transmembrane transporter activity GO:0005310 EXP
    dicarboxylic acid transmembrane transporter activity GO:0005310 TAS
    phosphate transmembrane transporter activity GO:0005315 IEA
    protein binding GO:0005515 IPI
    sulfate transmembrane transporter activity GO:0015116 IBA
    thiosulfate transmembrane transporter activity GO:0015117 IBA
    oxaloacetate transmembrane transporter activity GO:0015131 IBA
    malate transmembrane transporter activity GO:0015140 IBA
    succinate transmembrane transporter activity GO:0015141 IBA
    antiporter activity GO:0015297 IBA
Biological Process
    gluconeogenesis GO:0006094 TAS
    monoatomic ion transport GO:0006811 TAS
    dicarboxylic acid transport GO:0006835 TAS
    lipid transport GO:0006869 IEA
    thiosulfate transport GO:0015709 IBA
    oxaloacetate transport GO:0015729 IBA
    phosphate ion transmembrane transport GO:0035435 IBA
    glyceraldehyde-3-phosphate biosynthetic process GO:0046166 IEA
    sulfide oxidation, using sulfide:quinone oxidoreductase GO:0070221 TAS
    succinate transmembrane transport GO:0071422 IBA
    malate transmembrane transport GO:0071423 IBA
    oxaloacetate(2-) transmembrane transport GO:1902356 IEA
    sulfate transmembrane transport GO:1902358 IBA
Subcellular Localization
    nucleus GO:0005634 HDA
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 TAS
 Experiment description of studies that identified SLC25A10 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for SLC25A10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 SPRTN  
Affinity Capture-MS Homo sapiens
3 BCKDK 10295
Affinity Capture-MS Homo sapiens
4 COIL  
Proximity Label-MS Homo sapiens
5 CYP24A1  
Affinity Capture-MS Homo sapiens
6 LAMP3  
Proximity Label-MS Homo sapiens
7 ADRB2  
Affinity Capture-MS Homo sapiens
8 MDFI  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 ZC3H4 23211
Co-fractionation Homo sapiens
10 MRPL50 54534
Affinity Capture-MS Homo sapiens
11 KRTAP5-9  
Two-hybrid Homo sapiens
12 MUT 4594
Affinity Capture-MS Homo sapiens
13 NDUFA4 4697
Affinity Capture-MS Homo sapiens
14 STX4 6810
Co-fractionation Homo sapiens
15 ASXL1  
Affinity Capture-MS Homo sapiens
16 RTN4 57142
Co-fractionation Homo sapiens
17 SOX2  
Affinity Capture-MS Homo sapiens
18 KRTAP4-12  
Two-hybrid Homo sapiens
19 RUVBL1 8607
Affinity Capture-MS Homo sapiens
20 B3GNT2 10678
Affinity Capture-MS Homo sapiens
21 HSPA2 3306
Affinity Capture-MS Homo sapiens
22 COQ9  
Affinity Capture-MS Homo sapiens
23 NR2F6  
Affinity Capture-MS Homo sapiens
24 KRT40  
Two-hybrid Homo sapiens
25 MRPL12 6182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 KRTAP4-2  
Two-hybrid Homo sapiens
27 NSUN4  
Affinity Capture-MS Homo sapiens
28 TMEM192 201931
Affinity Capture-MS Homo sapiens
29 IVD 3712
Affinity Capture-MS Homo sapiens
30 MECP2 4204
Affinity Capture-MS Homo sapiens
31 Cct4 12464
Affinity Capture-MS Mus musculus
32 MYCN  
Affinity Capture-MS Homo sapiens
33 ACSF2 80221
Affinity Capture-MS Homo sapiens
34 FAF2 23197
Affinity Capture-MS Homo sapiens
35 LAMTOR1 55004
Proximity Label-MS Homo sapiens
36 HSPA8 3312
Affinity Capture-MS Homo sapiens
37 NDUFA13 51079
Co-fractionation Homo sapiens
38 NUP155 9631
Proximity Label-MS Homo sapiens
39 IRAK1  
Affinity Capture-MS Homo sapiens
40 PARK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 TUBA1A 7846
Affinity Capture-MS Homo sapiens
42 CPS1 1373
Affinity Capture-MS Homo sapiens
43 SARDH 1757
Affinity Capture-MS Homo sapiens
44 TBC1D32 221322
Proximity Label-MS Homo sapiens
45 NTRK1 4914
Affinity Capture-MS Homo sapiens
46 PITRM1 10531
Affinity Capture-MS Homo sapiens
47 TARS2 80222
Affinity Capture-MS Homo sapiens
48 RAB2A 5862
Proximity Label-MS Homo sapiens
49 PRR4 11272
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 KIAA0391  
Affinity Capture-MS Homo sapiens
51 RSAD1  
Affinity Capture-MS Homo sapiens
52 PCSK9 255738
Affinity Capture-MS Homo sapiens
53 NARS2  
Affinity Capture-MS Homo sapiens
54 TECR 9524
Affinity Capture-MS Homo sapiens
55 MRPS14  
Co-fractionation Homo sapiens
56 LARP1 23367
Co-fractionation Homo sapiens
57 ZNF326 284695
Co-fractionation Homo sapiens
58 NOTCH2NL 388677
Two-hybrid Homo sapiens
59 TMPO 7112
Affinity Capture-MS Homo sapiens
60 EARS2  
Affinity Capture-MS Homo sapiens
61 CLN3 1201
Affinity Capture-MS Homo sapiens
62 OTUD1 220213
Affinity Capture-MS Homo sapiens
63 ECT2 1894
Affinity Capture-MS Homo sapiens
64 KRTAP10-8  
Two-hybrid Homo sapiens
65 MRPL9 65005
Affinity Capture-MS Homo sapiens
66 ASPM 259266
Affinity Capture-MS Homo sapiens
67 CUL3 8452
Affinity Capture-MS Homo sapiens
68 ACAD10  
Affinity Capture-MS Homo sapiens
69 MCCC1 56922
Affinity Capture-MS Homo sapiens
70 PTK2 5747
Proximity Label-MS Homo sapiens
71 KRTAP10-3  
Two-hybrid Homo sapiens
72 NXF1 10482
Affinity Capture-RNA Homo sapiens
73 MRPS28  
Co-fractionation Homo sapiens
74 CECR5 27440
Affinity Capture-MS Homo sapiens
75 MRPL1  
Affinity Capture-MS Homo sapiens
76 CPT2 1376
Affinity Capture-MS Homo sapiens
77 MAPK6  
Affinity Capture-MS Homo sapiens
78 SOAT1 6646
Co-fractionation Homo sapiens
79 CST4 1472
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 LACRT 90070
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 FBXO6 26270
Affinity Capture-MS Homo sapiens
82 NEFM 4741
Proximity Label-MS Homo sapiens
83 DDRGK1 65992
Affinity Capture-MS Homo sapiens
84 RNF2  
Affinity Capture-MS Homo sapiens
85 BMI1  
Affinity Capture-MS Homo sapiens
86 ILK 3611
Affinity Capture-MS Homo sapiens
87 HSPD1 3329
Affinity Capture-MS Homo sapiens
88 PEX3 8504
Proximity Label-MS Homo sapiens
89 AKAP1 8165
Proximity Label-MS Homo sapiens
90 FLOT1 10211
Proximity Label-MS Homo sapiens
91 KRT18 3875
Proximity Label-MS Homo sapiens
92 CLPP 8192
Proximity Label-MS Homo sapiens
93 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
94 NAAA  
Affinity Capture-MS Homo sapiens
95 SCGB2A1 4246
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 FOXRED2  
Affinity Capture-MS Homo sapiens
97 TP53 7157
Affinity Capture-MS Homo sapiens
98 SCGB1D1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 ICT1 3396
Affinity Capture-MS Homo sapiens
100 BCKDHA 593
Affinity Capture-MS Homo sapiens
101 PDHA1 5160
Proximity Label-MS Homo sapiens
102 SQSTM1 8878
Proximity Label-MS Homo sapiens
103 CRAT 1384
Affinity Capture-MS Homo sapiens
104 RBAK  
Two-hybrid Homo sapiens
105 PNPT1 87178
Affinity Capture-MS Homo sapiens
106 TMLHE 55217
Affinity Capture-MS Homo sapiens
107 AGO4  
Affinity Capture-MS Homo sapiens
108 UFL1 23376
Affinity Capture-MS Homo sapiens
109 MOV10 4343
Affinity Capture-RNA Homo sapiens
110 EZH2  
Affinity Capture-MS Homo sapiens
111 TCF3  
Affinity Capture-MS Homo sapiens
112 ACSF3 197322
Affinity Capture-MS Homo sapiens
113 LDLR 3949
Positive Genetic Homo sapiens
114 C9orf72  
Affinity Capture-MS Homo sapiens
115 POLG  
Affinity Capture-MS Homo sapiens
116 DCP2  
Affinity Capture-MS Homo sapiens
117 EP300 2033
Affinity Capture-MS Homo sapiens
118 DARS2 55157
Affinity Capture-MS Homo sapiens
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