Gene description for SARDH
Gene name sarcosine dehydrogenase
Gene symbol SARDH
Other names/aliases BPR-2
DMGDHL1
SAR
SARD
SDH
Species Homo sapiens
 Database cross references - SARDH
ExoCarta ExoCarta_1757
Vesiclepedia VP_1757
Entrez Gene 1757
HGNC 10536
MIM 604455
UniProt Q9UL12  
 SARDH identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SARDH
Molecular Function
    sarcosine dehydrogenase activity GO:0008480 IBA
Biological Process
    sarcosine catabolic process GO:1901053 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 ISS
    mitochondrial matrix GO:0005759 IBA
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified SARDH in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SARDH
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NIPSNAP3A  
Affinity Capture-MS Homo sapiens
2 RAMP3  
Affinity Capture-MS Homo sapiens
3 UBE2N 7334
Co-fractionation Homo sapiens
4 AK4 205
Affinity Capture-MS Homo sapiens
5 C9orf163  
Affinity Capture-MS Homo sapiens
6 NAA38  
Affinity Capture-MS Homo sapiens
7 FOXRED2  
Affinity Capture-MS Homo sapiens
8 MRPS2 51116
Affinity Capture-MS Homo sapiens
9 KLK5 25818
Affinity Capture-MS Homo sapiens
10 MRPS30 10884
Affinity Capture-MS Homo sapiens
11 METTL20  
Affinity Capture-MS Homo sapiens
12 SLC25A10 1468
Affinity Capture-MS Homo sapiens
13 ACSM5 54988
Affinity Capture-MS Homo sapiens
14 NDUFS7 374291
Affinity Capture-MS Homo sapiens
15 FAHD1 81889
Affinity Capture-MS Homo sapiens
16 FKBP4 2288
Co-fractionation Homo sapiens
17 SNX21  
Affinity Capture-MS Homo sapiens
18 AMACR 23600
Affinity Capture-MS Homo sapiens
19 ADAM7  
Affinity Capture-MS Homo sapiens
20 GZMH  
Affinity Capture-MS Homo sapiens
21 TAZ  
Affinity Capture-MS Homo sapiens
22 C9orf173  
Affinity Capture-MS Homo sapiens
23 TRMU  
Affinity Capture-MS Homo sapiens
24 BCL2L12 83596
Affinity Capture-MS Homo sapiens
25 GPR45  
Affinity Capture-MS Homo sapiens
26 RPUSD3  
Affinity Capture-MS Homo sapiens
27 CLEC11A 6320
Affinity Capture-MS Homo sapiens
28 YARS2  
Affinity Capture-MS Homo sapiens
29 MRPS24 64951
Affinity Capture-MS Homo sapiens
30 GCAT  
Affinity Capture-MS Homo sapiens
31 RASL10B  
Affinity Capture-MS Homo sapiens
32 FOXD4L6  
Affinity Capture-MS Homo sapiens
33 SHC2 25759
Affinity Capture-MS Homo sapiens
34 DKKL1  
Affinity Capture-MS Homo sapiens
35 KLHL14 57565
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SARDH is involved
PathwayEvidenceSource
Choline catabolism TAS Reactome
Metabolism TAS Reactome
Metabolism of amino acids and derivatives TAS Reactome





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