Gene description for CDH6
Gene name cadherin 6, type 2, K-cadherin (fetal kidney)
Gene symbol CDH6
Other names/aliases CAD6
KCAD
Species Homo sapiens
 Database cross references - CDH6
ExoCarta ExoCarta_1004
Vesiclepedia VP_1004
Entrez Gene 1004
HGNC 1765
MIM 603007
UniProt P55285  
 CDH6 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CDH6
Molecular Function
    calcium ion binding GO:0005509 IEA
    beta-catenin binding GO:0008013 IBA
    cadherin binding GO:0045296 IBA
Biological Process
    cell morphogenesis GO:0000902 IBA
    cell-cell junction assembly GO:0007043 IBA
    cell adhesion GO:0007155 TAS
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    Notch signaling pathway GO:0007219 IEA
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 IBA
    cell migration GO:0016477 IBA
    adherens junction organization GO:0034332 IBA
    cell-cell adhesion mediated by cadherin GO:0044331 IBA
    synaptic membrane adhesion GO:0099560 IBA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    adherens junction GO:0005912 IBA
    catenin complex GO:0016342 IBA
    cell junction GO:0030054 IDA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified CDH6 in sEVs
1
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CDH6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDH6 1004
Co-localization Homo sapiens
Co-localization Homo sapiens
2 SREBF2 6721
Positive Genetic Homo sapiens
3 CTNNB1 1499
Affinity Capture-Western Homo sapiens
4 CDH18  
Co-localization Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here