Gene description for M6pr
Gene name mannose-6-phosphate receptor, cation dependent
Gene symbol M6pr
Other names/aliases CD-MPR
Mpr46
Species Mus musculus
 Database cross references - M6pr
ExoCarta ExoCarta_17113
Vesiclepedia VP_17113
Entrez Gene 17113
UniProt P24668  
 M6pr identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for M6pr
Molecular Function
    protein binding GO:0005515 IPI
    protein domain specific binding GO:0019904 IEA
    retromer complex binding GO:1905394 IEA
    retromer complex binding GO:1905394 ISO
Biological Process
    protein targeting to lysosome GO:0006622 IBA
    protein targeting to lysosome GO:0006622 IEA
    intracellular protein transport GO:0006886 TAS
    lysosomal transport GO:0007041 IDA
    secretion of lysosomal enzymes GO:0033299 IDA
Subcellular Localization
    lysosomal membrane GO:0005765 IEA
    endosome GO:0005768 ISO
    late endosome GO:0005770 IDA
    Golgi apparatus GO:0005794 IEA
    trans-Golgi network GO:0005802 IBA
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified M6pr in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for M6pr
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GLB1 2720
Affinity Capture-MS Homo sapiens
2 HTT 3064
Affinity Capture-MS Homo sapiens
3 BCAR1 9564
Affinity Capture-MS Homo sapiens
4 DDX60 55601
Affinity Capture-MS Homo sapiens
5 BRAP  
Affinity Capture-MS Homo sapiens
6 DPM1 8813
Affinity Capture-MS Homo sapiens
7 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
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