Gene description for Map1b
Gene name microtubule-associated protein 1B
Gene symbol Map1b
Other names/aliases A230055D22
AI843217
LC1
MAP5
Mtap-5
Mtap1b
Mtap5
Species Mus musculus
 Database cross references - Map1b
ExoCarta ExoCarta_17755
Vesiclepedia VP_17755
Entrez Gene 17755
UniProt P14873  
 Map1b identified in sEVs derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Map1b
Molecular Function
    actin binding GO:0003779 IBA
    actin binding GO:0003779 IEA
    actin binding GO:0003779 ISO
    protein binding GO:0005515 IPI
    cytoskeletal regulatory protein binding GO:0005519 TAS
    phospholipid binding GO:0005543 IEA
    phospholipid binding GO:0005543 ISO
    microtubule binding GO:0008017 IBA
    microtubule binding GO:0008017 IEA
    microtubule binding GO:0008017 ISO
    protein-containing complex binding GO:0044877 IEA
    protein-containing complex binding GO:0044877 ISO
Biological Process
    microtubule cytoskeleton organization GO:0000226 IBA
    microtubule bundle formation GO:0001578 IMP
    microtubule bundle formation GO:0001578 ISO
    microtubule-based process GO:0007017 TAS
    negative regulation of microtubule depolymerization GO:0007026 IEA
    negative regulation of microtubule depolymerization GO:0007026 ISO
    axonogenesis GO:0007409 IBA
    axonogenesis GO:0007409 IGI
    synapse assembly GO:0007416 IEA
    response to xenobiotic stimulus GO:0009410 IEA
    response to mechanical stimulus GO:0009612 IEA
    response to carbohydrate GO:0009743 IEA
    peripheral nervous system axon regeneration GO:0014012 IEA
    dendrite development GO:0016358 IBA
    dendrite development GO:0016358 IMP
    response to insecticide GO:0017085 IEA
    developmental maturation GO:0021700 IEA
    regulation of microtubule depolymerization GO:0031114 IBA
    positive regulation of microtubule polymerization GO:0031116 IEA
    positive regulation of microtubule polymerization GO:0031116 ISO
    neuron projection development GO:0031175 ISO
    neuron projection development GO:0031175 ISS
    response to estradiol GO:0032355 IEA
    negative regulation of intracellular transport GO:0032387 IMP
    response to vitamin A GO:0033189 IEA
    positive regulation of neuron differentiation GO:0045666 IEA
    positive regulation of neuron differentiation GO:0045666 ISO
    positive regulation of axon extension GO:0045773 IEA
    positive regulation of axon extension GO:0045773 ISO
    intracellular transport GO:0046907 IMP
    mitochondrion transport along microtubule GO:0047497 IMP
    axon extension GO:0048675 IMP
    induction of synaptic plasticity by chemical substance GO:0051915 IEA
    establishment of monopolar cell polarity GO:0061162 IMP
    cellular response to growth factor stimulus GO:0071363 IEA
    cellular response to peptide hormone stimulus GO:0071375 IEA
    odontoblast differentiation GO:0071895 IEA
    regulation of postsynapse assembly GO:0150052 IDA
    regulation of postsynapse assembly GO:0150052 IMP
Subcellular Localization
    photoreceptor outer segment GO:0001750 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 ISO
    microtubule GO:0005874 IBA
    microtubule GO:0005874 IEA
    microtubule GO:0005874 ISO
    microtubule associated complex GO:0005875 IBA
    microtubule associated complex GO:0005875 ISO
    microtubule associated complex GO:0005875 TAS
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    postsynaptic density GO:0014069 IDA
    axon GO:0030424 ISO
    dendrite GO:0030425 IBA
    dendrite GO:0030425 IDA
    dendrite GO:0030425 ISO
    growth cone GO:0030426 IEA
    growth cone GO:0030426 ISO
    somatodendritic compartment GO:0036477 ISO
    neuronal cell body GO:0043025 IBA
    neuronal cell body GO:0043025 IDA
    neuronal cell body GO:0043025 ISO
    varicosity GO:0043196 IEA
    varicosity GO:0043196 ISO
    dendritic spine GO:0043197 IEA
    perikaryon GO:0043204 IEA
    perikaryon GO:0043204 ISO
    synapse GO:0045202 IBA
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
    apical dendrite GO:0097440 IEA
    apical dendrite GO:0097440 ISO
    basal dendrite GO:0097441 IEA
    basal dendrite GO:0097441 ISO
    hippocampal mossy fiber GO:0097457 IEA
    hippocampal mossy fiber GO:0097457 ISO
    postsynapse GO:0098794 IDA
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified Map1b in sEVs
1
Experiment ID 188
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Map1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Map1lc3a  
Affinity Capture-MS Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Nxf2  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
4 Elf5  
Affinity Capture-MS Mus musculus
5 HTT 3064
Affinity Capture-MS Homo sapiens
6 SNCA 6622
Affinity Capture-MS Homo sapiens
7 Nxf7  
Affinity Capture-Western Mus musculus
8 Fzr1  
Affinity Capture-MS Mus musculus
9 Tsr2  
Co-fractionation Mus musculus
10 Ube2r2  
Co-fractionation Mus musculus
11 Stau1  
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
12 Cntnap2  
Affinity Capture-MS Mus musculus
13 Pafah1b1 18472
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
14 Iqcb1  
Affinity Capture-MS Mus musculus
15 Strap 20901
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
16 Fancd2  
Affinity Capture-MS Mus musculus
17 Nxf1  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
18 Ywhae 22627
Affinity Capture-MS Mus musculus
19 Nbr1  
Two-hybrid Mus musculus
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
20 U2af1 108121
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Map1b is involved
No pathways found





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