Gene description for TYMP
Gene name thymidine phosphorylase
Gene symbol TYMP
Other names/aliases ECGF
ECGF1
MEDPS1
MNGIE
MTDPS1
PDECGF
TP
hPD-ECGF
Species Homo sapiens
 Database cross references - TYMP
ExoCarta ExoCarta_1890
Vesiclepedia VP_1890
Entrez Gene 1890
HGNC 3148
MIM 131222
UniProt P19971  
 TYMP identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Thymus 23844026    
 Gene ontology annotations for TYMP
Molecular Function
    1,4-alpha-oligoglucan phosphorylase activity GO:0004645 IEA
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
    thymidine phosphorylase activity GO:0009032 IDA
    thymidine phosphorylase activity GO:0009032 IMP
    protein homodimerization activity GO:0042803 IDA
Biological Process
    mitochondrial genome maintenance GO:0000002 IMP
    angiogenesis GO:0001525 IEA
    pyrimidine nucleobase metabolic process GO:0006206 IEA
    pyrimidine nucleoside metabolic process GO:0006213 IDA
    pyrimidine nucleoside metabolic process GO:0006213 IMP
    chemotaxis GO:0006935 IEA
    signal transduction GO:0007165 IEA
    cell differentiation GO:0030154 IEA
    regulation of myelination GO:0031641 IMP
    dTMP catabolic process GO:0046074 IEA
    regulation of transmission of nerve impulse GO:0051969 IMP
    regulation of gastric motility GO:1905333 IMP
Subcellular Localization
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified TYMP in sEVs
1
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 219
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name C666-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 220
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP69
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 221
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP460
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 217
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TYMP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NUDCD1 84955
Co-fractionation Homo sapiens
2 ERCC3  
Affinity Capture-MS Homo sapiens
3 ZSCAN20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CCDC94  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CHMP3 51652
Affinity Capture-MS Homo sapiens
6 Cdk1 12534
Affinity Capture-MS Mus musculus
7 KIAA0907  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 PSMA3 5684
Affinity Capture-MS Homo sapiens
9 HCN1  
Affinity Capture-MS Homo sapiens
10 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
11 CCNC  
Affinity Capture-MS Homo sapiens
12 SLC25A6 293
Affinity Capture-MS Homo sapiens
13 C18orf21  
Affinity Capture-MS Homo sapiens
14 APTX  
Affinity Capture-MS Homo sapiens
15 TYMP 1890
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
16 LIAS  
Affinity Capture-MS Homo sapiens
17 AGPAT1 10554
Affinity Capture-MS Homo sapiens
18 ZDHHC19  
Affinity Capture-MS Homo sapiens
19 RPS6KL1  
Affinity Capture-MS Homo sapiens
20 RBM24 221662
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 NRSN1  
Affinity Capture-MS Homo sapiens
22 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SH2D3A  
Affinity Capture-MS Homo sapiens
24 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 EPHA8  
Affinity Capture-MS Homo sapiens
26 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 SLC37A4 2542
Affinity Capture-MS Homo sapiens
28 ZNF154  
Affinity Capture-MS Homo sapiens
29 PCP4  
Affinity Capture-MS Homo sapiens
30 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
31 FAM60A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SCGB1D1  
Affinity Capture-MS Homo sapiens
33 NHLRC2 374354
Affinity Capture-MS Homo sapiens
34 C1orf35  
Affinity Capture-MS Homo sapiens
35 SSBP2  
Affinity Capture-MS Homo sapiens
36 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
37 TREX2  
Affinity Capture-MS Homo sapiens
38 PTDSS1 9791
Affinity Capture-MS Homo sapiens
39 EIF4E 1977
Co-fractionation Homo sapiens
40 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
41 FUNDC2 65991
Affinity Capture-MS Homo sapiens
42 ST7  
Affinity Capture-MS Homo sapiens
43 DERA 51071
Co-fractionation Homo sapiens
44 MBNL1 4154
Affinity Capture-MS Homo sapiens
45 PINK1  
Affinity Capture-MS Homo sapiens
46 CERS3  
Affinity Capture-MS Homo sapiens
47 SUSD3 203328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 KLHL11  
Affinity Capture-MS Homo sapiens
49 RHBDD1 84236
Affinity Capture-MS Homo sapiens
50 RNF115  
Affinity Capture-MS Homo sapiens
51 EEF2 1938
Co-fractionation Homo sapiens
52 PI4KA 5297
Affinity Capture-MS Homo sapiens
53 ASCL1  
Affinity Capture-MS Homo sapiens
54 GPATCH2L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 PI4KAP1  
Affinity Capture-MS Homo sapiens
56 FAM227B  
Affinity Capture-MS Homo sapiens
57 SYT6  
Affinity Capture-MS Homo sapiens
58 HDDC2 51020
Co-fractionation Homo sapiens
59 TEFM  
Affinity Capture-MS Homo sapiens
60 SARAF  
Affinity Capture-MS Homo sapiens
61 PIGT 51604
Affinity Capture-MS Homo sapiens
62 COA5  
Affinity Capture-MS Homo sapiens
63 RAB11A 8766
Affinity Capture-MS Homo sapiens
64 GOT1 2805
Affinity Capture-MS Homo sapiens
65 UPK1A 11045
Affinity Capture-MS Homo sapiens
66 GAPDH 2597
Co-fractionation Homo sapiens
67 SSUH2  
Affinity Capture-MS Homo sapiens
68 ANKRD36B  
Affinity Capture-MS Homo sapiens
69 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 POU3F3  
Affinity Capture-MS Homo sapiens
71 ARF5 381
Co-fractionation Homo sapiens
72 GUCY1A3  
Affinity Capture-MS Homo sapiens
73 GMCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 DDX58 23586
Affinity Capture-RNA Homo sapiens
75 GABPA 2551
Affinity Capture-MS Homo sapiens
76 CCR1  
Affinity Capture-MS Homo sapiens
77 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
78 STX17 55014
Affinity Capture-MS Homo sapiens
79 RIPPLY3  
Affinity Capture-MS Homo sapiens
80 SOX2  
Affinity Capture-MS Homo sapiens
81 OR2A4 79541
Affinity Capture-MS Homo sapiens
82 PHF11 51131
Affinity Capture-MS Homo sapiens
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