Gene description for Ptprj
Gene name protein tyrosine phosphatase, receptor type, J
Gene symbol Ptprj
Other names/aliases AI450271
BET
Byp
CD148
DEP-1
PTPbeta2
Ptpb2
RPTPJ
Scc-1
Scc1
Species Mus musculus
 Database cross references - Ptprj
ExoCarta ExoCarta_19271
Vesiclepedia VP_19271
Entrez Gene 19271
UniProt Q64455  
 Ptprj identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ptprj
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IBA
    protein tyrosine phosphatase activity GO:0004725 IMP
    protein tyrosine phosphatase activity GO:0004725 ISO
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    platelet-derived growth factor receptor binding GO:0005161 IEA
    platelet-derived growth factor receptor binding GO:0005161 ISO
    beta-catenin binding GO:0008013 IEA
    beta-catenin binding GO:0008013 ISO
    phosphatase activity GO:0016791 ISO
    phosphatase activity GO:0016791 ISS
    protein kinase binding GO:0019901 ISO
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    gamma-catenin binding GO:0045295 IEA
    gamma-catenin binding GO:0045295 ISO
    cadherin binding GO:0045296 IEA
    cadherin binding GO:0045296 ISO
    mitogen-activated protein kinase binding GO:0051019 IEA
    mitogen-activated protein kinase binding GO:0051019 ISO
    delta-catenin binding GO:0070097 IEA
    delta-catenin binding GO:0070097 ISO
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    vasculogenesis GO:0001570 IMP
    positive regulation of cell-matrix adhesion GO:0001954 IDA
    chromatin remodeling GO:0006338 IEA
    signal transduction GO:0007165 IBA
    axon guidance GO:0007411 IBA
    heart development GO:0007507 IMP
    blood coagulation GO:0007596 IMP
    negative regulation of cell population proliferation GO:0008285 IMP
    negative regulation of cell population proliferation GO:0008285 ISO
    positive regulation of platelet activation GO:0010572 IMP
    negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 IDA
    negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 ISO
    positive regulation of macrophage chemotaxis GO:0010759 IDA
    regulation of cell adhesion GO:0030155 ISO
    B cell differentiation GO:0030183 IMP
    platelet formation GO:0030220 ISO
    platelet formation GO:0030220 ISS
    negative regulation of cell growth GO:0030308 IEA
    negative regulation of cell growth GO:0030308 ISO
    negative regulation of cell migration GO:0030336 IDA
    negative regulation of cell migration GO:0030336 ISO
    positive regulation of tumor necrosis factor production GO:0032760 IGI
    peptidyl-tyrosine dephosphorylation GO:0035335 ISO
    negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 ISO
    negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 ISS
    glucose homeostasis GO:0042593 IMP
    negative regulation of vascular permeability GO:0043116 IEA
    negative regulation of vascular permeability GO:0043116 ISO
    negative regulation of MAP kinase activity GO:0043407 IDA
    negative regulation of MAP kinase activity GO:0043407 ISO
    positive regulation of MAPK cascade GO:0043410 IGI
    positive regulation of cell adhesion GO:0045785 ISO
    negative regulation of insulin receptor signaling pathway GO:0046627 IMP
    platelet-derived growth factor receptor signaling pathway GO:0048008 ISO
    platelet-derived growth factor receptor signaling pathway GO:0048008 ISS
    oligodendrocyte differentiation GO:0048709 IMP
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IGI
    positive regulation of phagocytosis GO:0050766 IGI
    positive regulation of calcium-mediated signaling GO:0050850 IGI
    negative regulation of T cell receptor signaling pathway GO:0050860 IDA
    negative regulation of T cell receptor signaling pathway GO:0050860 ISO
    positive chemotaxis GO:0050918 IEA
    positive chemotaxis GO:0050918 ISO
    positive regulation of focal adhesion assembly GO:0051894 ISO
    positive regulation of focal adhesion assembly GO:0051894 ISS
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 ISO
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 ISS
    positive regulation of Fc receptor mediated stimulatory signaling pathway GO:0060369 IGI
    peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity GO:1990264 IMP
    negative regulation of signaling receptor activity GO:2000272 IMP
Subcellular Localization
    immunological synapse GO:0001772 IDA
    immunological synapse GO:0001772 ISO
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    cell-cell junction GO:0005911 ISO
    cell-cell junction GO:0005911 ISS
    cell surface GO:0009986 IEA
    cell surface GO:0009986 ISO
    ruffle membrane GO:0032587 IDA
 Experiment description of studies that identified Ptprj in sEVs
1
Experiment ID 907
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ptprj
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ptpn14  
Co-fractionation Mus musculus
2 Ptprb  
Co-fractionation Mus musculus
3 Ptpn2  
Co-fractionation Mus musculus
4 Sstr3  
Proximity Label-MS Mus musculus
5 Ptpre  
Co-fractionation Mus musculus
6 Ptprs 19280
Co-fractionation Mus musculus
7 Ptpn13  
Co-fractionation Mus musculus
8 Ptpru  
Co-fractionation Mus musculus
9 Ptprg  
Co-fractionation Mus musculus
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