Gene description for Ptprs
Gene name protein tyrosine phosphatase, receptor type, S
Gene symbol Ptprs
Other names/aliases AL022616
PTP
PTP-NU3
PTPNU-3
PTPsigma
Ptpt9
R-PTP-S
RPTPsigma
Species Mus musculus
 Database cross references - Ptprs
ExoCarta ExoCarta_19280
Vesiclepedia VP_19280
Entrez Gene 19280
UniProt B0V2N1  
 Ptprs identified in sEVs derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Ptprs
Molecular Function
    phosphoprotein phosphatase activity GO:0004721 ISO
    protein tyrosine phosphatase activity GO:0004725 IBA
    protein tyrosine phosphatase activity GO:0004725 IDA
    protein tyrosine phosphatase activity GO:0004725 ISO
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IDA
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    chondroitin sulfate binding GO:0035374 IDA
    heparan sulfate proteoglycan binding GO:0043395 ISS
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    protein dephosphorylation GO:0006470 ISO
    signal transduction GO:0007165 IBA
    negative regulation of neuron projection development GO:0010977 IMP
    spinal cord development GO:0021510 IMP
    cerebellum development GO:0021549 IMP
    hippocampus development GO:0021766 IMP
    cerebral cortex development GO:0021987 IMP
    corpus callosum development GO:0022038 IMP
    negative regulation of axon extension GO:0030517 IMP
    negative regulation of interferon-alpha production GO:0032687 IEA
    negative regulation of interferon-alpha production GO:0032687 ISO
    negative regulation of interferon-beta production GO:0032688 IEA
    negative regulation of interferon-beta production GO:0032688 ISO
    negative regulation of toll-like receptor 9 signaling pathway GO:0034164 IEA
    negative regulation of toll-like receptor 9 signaling pathway GO:0034164 ISO
    peptidyl-tyrosine dephosphorylation GO:0035335 IDA
    peptidyl-tyrosine dephosphorylation GO:0035335 IMP
    negative regulation of collateral sprouting GO:0048671 IMP
    negative regulation of axon regeneration GO:0048681 IMP
    modulation of chemical synaptic transmission GO:0050804 IDA
    modulation of chemical synaptic transmission GO:0050804 IMP
    synapse organization GO:0050808 IDA
    synapse organization GO:0050808 IMP
    negative regulation of dendritic spine development GO:0061000 IMP
    establishment of endothelial intestinal barrier GO:0090557 IMP
    presynapse assembly GO:0099054 ISO
    regulation of postsynaptic density assembly GO:0099151 IDA
    regulation of postsynaptic density assembly GO:0099151 IMP
    regulation of postsynaptic density assembly GO:0099151 ISO
    trans-synaptic signaling GO:0099537 IDA
    trans-synaptic signaling GO:0099537 IMP
    synaptic membrane adhesion GO:0099560 IBA
    synaptic membrane adhesion GO:0099560 IEA
    synaptic membrane adhesion GO:0099560 ISO
Subcellular Localization
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    axon GO:0030424 ISS
    growth cone GO:0030426 IEA
    synaptic vesicle membrane GO:0030672 ISO
    synaptic vesicle membrane GO:0030672 ISS
    presynaptic membrane GO:0042734 IDA
    presynaptic membrane GO:0042734 ISO
    perikaryon GO:0043204 IEA
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IMP
    postsynaptic density membrane GO:0098839 ISO
    postsynaptic density membrane GO:0098839 ISS
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Ptprs in sEVs
1
Experiment ID 1101
MISEV standards
EM
Biophysical techniques
Cd81|Cd9|Tfrc|Gapdh|Lamp1
Enriched markers
GOLGA2|CANX
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1102
MISEV standards
EM
Biophysical techniques
Cd81|Cd9|Tfrc|Gapdh|Lamp1
Enriched markers
GOLGA2|CANX
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F10
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
Flow cytometry
3
Experiment ID 1103
MISEV standards
EM
Biophysical techniques
Cd81|Cd9|Tfrc|Gapdh|Lamp1
Enriched markers
GOLGA2|CANX
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for Ptprs
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPRF 5792
Affinity Capture-Western Homo sapiens
2 Tnik  
Affinity Capture-MS Mus musculus
3 Ptprb  
Co-fractionation Mus musculus
4 Ptpn2  
Co-fractionation Mus musculus
5 PTPRM 5797
Affinity Capture-Western Homo sapiens
6 Ptprf  
Co-fractionation Mus musculus
7 Ptpn6 15170
Co-fractionation Mus musculus
8 Ptpn3  
Co-fractionation Mus musculus
9 Ptprg  
Co-fractionation Mus musculus
10 Ptpra 19262
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
11 Tsc1  
Affinity Capture-MS Mus musculus
12 Kctd13  
Affinity Capture-MS Mus musculus
13 Ptpre  
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
14 Ptprc 19264
Affinity Capture-Western Mus musculus
15 Ptprm  
Co-fractionation Mus musculus
16 Tmem173  
Proximity Label-MS Mus musculus
17 Ptprq  
Co-fractionation Mus musculus
18 Ptprj 19271
Co-fractionation Mus musculus
19 Ptpru  
Co-fractionation Mus musculus
20 Ptpn14  
Co-fractionation Mus musculus
21 Ptpn13  
Co-fractionation Mus musculus
22 Fancd2  
Affinity Capture-MS Mus musculus
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