Gene description for APOBEC3F
Gene name apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
Gene symbol APOBEC3F
Other names/aliases A3F
ARP8
BK150C2.4.MRNA
KA6
Species Homo sapiens
 Database cross references - APOBEC3F
ExoCarta ExoCarta_200316
Vesiclepedia VP_200316
Entrez Gene 200316
HGNC 17356
MIM 608993
UniProt Q8IUX4  
 APOBEC3F identified in sEVs derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for APOBEC3F
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IBA
    RNA binding GO:0003723 IDA
    cytidine deaminase activity GO:0004126 IBA
    cytidine deaminase activity GO:0004126 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    positive regulation of defense response to virus by host GO:0002230 IDA
    transposable element silencing GO:0010526 IDA
    base conversion or substitution editing GO:0016553 IDA
    cytidine to uridine editing GO:0016554 IBA
    positive regulation of gene expression via chromosomal CpG island demethylation GO:0044029 IDA
    clearance of foreign intracellular DNA GO:0044355 IDA
    negative regulation of viral genome replication GO:0045071 IDA
    innate immune response GO:0045087 IDA
    negative regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045869 IBA
    negative regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045869 IDA
    negative regulation of viral process GO:0048525 IDA
    defense response to virus GO:0051607 IBA
    defense response to virus GO:0051607 IDA
    DNA cytosine deamination GO:0070383 IBA
    DNA cytosine deamination GO:0070383 IDA
Subcellular Localization
    P-body GO:0000932 IBA
    P-body GO:0000932 IDA
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    apolipoprotein B mRNA editing enzyme complex GO:0030895 TAS
    ribonucleoprotein complex GO:1990904 IDA
 Experiment description of studies that identified APOBEC3F in sEVs
1
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for APOBEC3F
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACD  
Two-hybrid Homo sapiens
2 ZNF574  
Affinity Capture-MS Homo sapiens
3 RALY 22913
Affinity Capture-MS Homo sapiens
4 NUPL2 11097
Affinity Capture-MS Homo sapiens
5 ELAVL2 1993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 YBX1 4904
Affinity Capture-MS Homo sapiens
7 HNRNPC 3183
Affinity Capture-MS Homo sapiens
8 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
9 ARIH2 10425
Biochemical Activity Homo sapiens
10 ABT1 29777
Affinity Capture-MS Homo sapiens
11 ZNF346  
Affinity Capture-MS Homo sapiens
12 RBMS3  
Affinity Capture-MS Homo sapiens
13 LARP4B 23185
Affinity Capture-MS Homo sapiens
14 LIN28A  
Affinity Capture-MS Homo sapiens
15 RBM47 54502
Affinity Capture-MS Homo sapiens
16 APOBEC3D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 SRSF4 6429
Affinity Capture-MS Homo sapiens
18 RTP3  
Affinity Capture-MS Homo sapiens
19 DGCR8  
Affinity Capture-MS Homo sapiens
20 ZNF71  
Affinity Capture-MS Homo sapiens
21 KIF20A 10112
Affinity Capture-MS Homo sapiens
22 SRSF5 6430
Affinity Capture-MS Homo sapiens
23 COQ4  
Affinity Capture-MS Homo sapiens
24 H2AFB3  
Affinity Capture-MS Homo sapiens
25 TRA2A 29896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 RPL19 6143
Affinity Capture-MS Homo sapiens
27 RNF7  
Biochemical Activity Homo sapiens
28 ILF2 3608
Affinity Capture-MS Homo sapiens
29 SRSF6 6431
Affinity Capture-MS Homo sapiens
30 PURG  
Affinity Capture-MS Homo sapiens
31 RBFOX2 23543
Affinity Capture-MS Homo sapiens
32 PRR3  
Affinity Capture-MS Homo sapiens
33 NEIL1  
Affinity Capture-MS Homo sapiens
34 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
35 RPL35 11224
Affinity Capture-MS Homo sapiens
36 SNRNP70 6625
Affinity Capture-MS Homo sapiens
37 RNPS1 10921
Affinity Capture-MS Homo sapiens
38 DND1  
Affinity Capture-MS Homo sapiens
39 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
40 GSPT2 23708
Affinity Capture-MS Homo sapiens
41 ZC3H18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 RPL31 6160
Affinity Capture-MS Homo sapiens
43 RPL7A 6130
Affinity Capture-MS Homo sapiens
44 PABPC5 140886
Affinity Capture-MS Homo sapiens
45 RPS6 6194
Affinity Capture-MS Homo sapiens
46 CBX6  
Affinity Capture-MS Homo sapiens
47 LYAR 55646
Affinity Capture-MS Homo sapiens
48 HNRNPU 3192
Affinity Capture-MS Homo sapiens
49 BMI1  
Affinity Capture-MS Homo sapiens
50 CLK3  
Affinity Capture-MS Homo sapiens
51 TINF2  
Two-hybrid Homo sapiens
52 SRSF7 6432
Affinity Capture-MS Homo sapiens
53 ZC3H3  
Affinity Capture-MS Homo sapiens
54 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
55 SNRPC 6631
Affinity Capture-MS Homo sapiens
56 PRKRA 8575
Affinity Capture-MS Homo sapiens
57 RBMS2 5939
Affinity Capture-MS Homo sapiens
58 RPS16 6217
Affinity Capture-MS Homo sapiens
59 PAIP1 10605
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which APOBEC3F is involved
No pathways found





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