Gene description for PABPC5
Gene name poly(A) binding protein, cytoplasmic 5
Gene symbol PABPC5
Other names/aliases PABP5
Species Homo sapiens
 Database cross references - PABPC5
ExoCarta ExoCarta_140886
Vesiclepedia VP_140886
Entrez Gene 140886
HGNC 13629
MIM 300407
UniProt Q96DU9  
 PABPC5 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
 Gene ontology annotations for PABPC5
Molecular Function
    mRNA 3'-UTR binding GO:0003730 IBA
    protein binding GO:0005515 IPI
    poly(A) binding GO:0008143 IBA
    poly(U) RNA binding GO:0008266 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    mitochondrial matrix GO:0005759 IDA
    mitochondrial matrix GO:0005759 IEA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytoplasmic stress granule GO:0010494 IBA
    ribonucleoprotein complex GO:1990904 IBA
 Experiment description of studies that identified PABPC5 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for PABPC5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RALY 22913
Affinity Capture-MS Homo sapiens
2 RBMXL1  
Affinity Capture-MS Homo sapiens
3 HNRNPC 3183
Affinity Capture-MS Homo sapiens
4 RPL26L1 51121
Affinity Capture-MS Homo sapiens
5 SYCP1  
Cross-Linking-MS (XL-MS) Homo sapiens
6 ZCCHC8 55596
Affinity Capture-MS Homo sapiens
7 PKM 5315
Cross-Linking-MS (XL-MS) Homo sapiens
8 TARDBP 23435
Cross-Linking-MS (XL-MS) Homo sapiens
9 ZC3H14  
Affinity Capture-MS Homo sapiens
10 LARP1B 55132
Affinity Capture-MS Homo sapiens
11 KIF20A 10112
Affinity Capture-MS Homo sapiens
12 ZFR 51663
Affinity Capture-MS Homo sapiens
13 PUM2 23369
Affinity Capture-MS Homo sapiens
14 HNRNPCL1 343069
Affinity Capture-MS Homo sapiens
15 DHX57 90957
Affinity Capture-MS Homo sapiens
16 MRPL52  
Affinity Capture-MS Homo sapiens
17 AQR 9716
Affinity Capture-MS Homo sapiens
18 SRSF8 10929
Affinity Capture-MS Homo sapiens
19 CWF19L2  
Affinity Capture-MS Homo sapiens
20 YTHDC1  
Affinity Capture-MS Homo sapiens
21 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
22 ELAVL3  
Affinity Capture-MS Homo sapiens
23 SRSF10 10772
Affinity Capture-MS Homo sapiens
24 HELZ 9931
Affinity Capture-MS Homo sapiens
25 PABPC4L 132430
Affinity Capture-MS Homo sapiens
26 ISY1 57461
Affinity Capture-MS Homo sapiens
27 NCOA5  
Affinity Capture-MS Homo sapiens
28 DUSP11  
Affinity Capture-MS Homo sapiens
29 ZSCAN21  
Affinity Capture-MS Homo sapiens
30 SRRM2 23524
Affinity Capture-MS Homo sapiens
31 KRI1  
Affinity Capture-MS Homo sapiens
32 HELZ2  
Affinity Capture-MS Homo sapiens
33 TRA2A 29896
Affinity Capture-MS Homo sapiens
34 ZCCHC3  
Affinity Capture-MS Homo sapiens
35 STAU2 27067
Affinity Capture-MS Homo sapiens
36 PRKRA 8575
Affinity Capture-MS Homo sapiens
37 FASTKD2  
Affinity Capture-MS Homo sapiens
38 BUD31 8896
Affinity Capture-MS Homo sapiens
39 PABPC4 8761
Cross-Linking-MS (XL-MS) Homo sapiens
40 FAM120A 23196
Affinity Capture-MS Homo sapiens
41 MTERF3  
Affinity Capture-MS Homo sapiens
42 CHERP 10523
Affinity Capture-MS Homo sapiens
43 KIF14 9928
Affinity Capture-MS Homo sapiens
44 LARP4B 23185
Affinity Capture-MS Homo sapiens
45 ATXN2 6311
Affinity Capture-MS Homo sapiens
46 IGF2BP2 10644
Affinity Capture-MS Homo sapiens
47 CLK2 1196
Affinity Capture-MS Homo sapiens
48 ZCCHC9  
Affinity Capture-MS Homo sapiens
49 PHAX  
Affinity Capture-MS Homo sapiens
50 C17orf85  
Affinity Capture-MS Homo sapiens
51 YBX2 51087
Affinity Capture-MS Homo sapiens
52 RBM7  
Affinity Capture-MS Homo sapiens
53 STAU1 6780
Affinity Capture-MS Homo sapiens
54 ACIN1 22985
Affinity Capture-MS Homo sapiens
55 PTCD1 26024
Affinity Capture-MS Homo sapiens
56 SRRT 51593
Affinity Capture-MS Homo sapiens
57 PABPC1 26986
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
58 MKRN2 23609
Affinity Capture-MS Homo sapiens
59 RFX3 5991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 ASCC2 84164
Affinity Capture-MS Homo sapiens
61 SRSF1 6426
Affinity Capture-MS Homo sapiens
62 PABPN1 8106
Affinity Capture-MS Homo sapiens
63 TRUB2  
Affinity Capture-MS Homo sapiens
64 REXO1L1P  
Affinity Capture-MS Homo sapiens
65 SAFB2 9667
Affinity Capture-MS Homo sapiens
66 HNRNPA3 220988
Affinity Capture-MS Homo sapiens
67 U2SURP 23350
Affinity Capture-MS Homo sapiens
68 CCDC12  
Affinity Capture-MS Homo sapiens
69 LARP1 23367
Affinity Capture-MS Homo sapiens
70 ZNF326 284695
Affinity Capture-MS Homo sapiens
71 ANLN 54443
Affinity Capture-MS Homo sapiens
72 PAIP2B  
Affinity Capture-MS Homo sapiens
73 RBBP6 5930
Affinity Capture-MS Homo sapiens
74 SF3B2 10992
Affinity Capture-MS Homo sapiens
75 ASCC3 10973
Affinity Capture-MS Homo sapiens
76 CLK3  
Affinity Capture-MS Homo sapiens
77 PAN3 255967
Affinity Capture-MS Homo sapiens
78 RC3H2  
Affinity Capture-MS Homo sapiens
79 ECT2 1894
Affinity Capture-MS Homo sapiens
80 YBX1 4904
Affinity Capture-MS Homo sapiens
81 PNN 5411
Affinity Capture-MS Homo sapiens
82 DHX36 170506
Affinity Capture-MS Homo sapiens
83 DHX29 54505
Affinity Capture-MS Homo sapiens
84 XAB2 56949
Affinity Capture-MS Homo sapiens
85 HPCAL1 3241
Affinity Capture-MS Homo sapiens
86 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
87 DHX30 22907
Affinity Capture-MS Homo sapiens
88 ZC3H11A  
Affinity Capture-MS Homo sapiens
89 SLTM 79811
Affinity Capture-MS Homo sapiens
90 APOBEC3B 9582
Affinity Capture-MS Homo sapiens
91 PPHLN1  
Affinity Capture-MS Homo sapiens
92 MKRN1 23608
Affinity Capture-MS Homo sapiens
93 PRR3  
Affinity Capture-MS Homo sapiens
94 CCDC9  
Affinity Capture-MS Homo sapiens
95 DKC1 1736
Affinity Capture-MS Homo sapiens
96 APOBEC3F 200316
Affinity Capture-MS Homo sapiens
97 ZC3H18  
Affinity Capture-MS Homo sapiens
98 DDX54 79039
Affinity Capture-MS Homo sapiens
99 MATR3 9782
Affinity Capture-MS Homo sapiens
100 HDLBP 3069
Affinity Capture-MS Homo sapiens
101 CSDE1 7812
Affinity Capture-MS Homo sapiens
102 LARP4 113251
Affinity Capture-MS Homo sapiens
103 RBMS2 5939
Affinity Capture-MS Homo sapiens
104 C10orf2 56652
Affinity Capture-MS Homo sapiens
105 TRIM71  
Affinity Capture-MS Homo sapiens
106 PAIP1 10605
Affinity Capture-MS Homo sapiens
107 HERC1 8925
Affinity Capture-MS Homo sapiens
108 YTHDC2 64848
Affinity Capture-MS Homo sapiens
109 ESR2  
Affinity Capture-MS Homo sapiens
110 RBM45  
Affinity Capture-MS Homo sapiens
111 RBM19 9904
Affinity Capture-MS Homo sapiens
112 ILF3 3609
Affinity Capture-MS Homo sapiens
113 HNRNPR 10236
Affinity Capture-MS Homo sapiens
114 IREB2 3658
Affinity Capture-MS Homo sapiens
115 APOBEC3D  
Affinity Capture-MS Homo sapiens
116 PPIG 9360
Affinity Capture-MS Homo sapiens
117 SRSF9 8683
Affinity Capture-MS Homo sapiens
118 AURKB 9212
Affinity Capture-MS Homo sapiens
119 NUFIP2 57532
Affinity Capture-MS Homo sapiens
120 RPS15 6209
Affinity Capture-MS Homo sapiens
121 PTBP3 9991
Affinity Capture-MS Homo sapiens
122 ELAVL2 1993
Affinity Capture-MS Homo sapiens
123 TRA2B 6434
Affinity Capture-MS Homo sapiens
124 SUGP2  
Affinity Capture-MS Homo sapiens
125 FAM120C 54954
Affinity Capture-MS Homo sapiens
126 MOV10 4343
Affinity Capture-MS Homo sapiens
127 YBX3 8531
Affinity Capture-MS Homo sapiens
128 UPF1 5976
Affinity Capture-MS Homo sapiens
129 PUM1 9698
Affinity Capture-MS Homo sapiens
130 PABPC1L 80336
Affinity Capture-MS Homo sapiens
131 PAIP2  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
132 ZC3H13 23091
Affinity Capture-MS Homo sapiens
133 RC3H1 149041
Affinity Capture-MS Homo sapiens
134 STRBP 55342
Affinity Capture-MS Homo sapiens
135 MRPS9 64965
Affinity Capture-MS Homo sapiens
136 CASC3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PABPC5 is involved
No pathways found





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