Gene description for PAN3
Gene name PAN3 poly(A) specific ribonuclease subunit
Gene symbol PAN3
Other names/aliases -
Species Homo sapiens
 Database cross references - PAN3
ExoCarta ExoCarta_255967
Vesiclepedia VP_255967
Entrez Gene 255967
HGNC 29991
UniProt Q58A45  
 PAN3 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for PAN3
Molecular Function
    poly(A)-specific ribonuclease activity GO:0004535 IDA
    protein kinase activity GO:0004672 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    poly(A) binding GO:0008143 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    nuclear-transcribed mRNA poly(A) tail shortening GO:0000289 IBA
    deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0000290 IEA
    mRNA processing GO:0006397 IEA
    protein targeting GO:0006605 IEA
    positive regulation of cytoplasmic mRNA processing body assembly GO:0010606 IEA
Subcellular Localization
    P-body GO:0000932 IBA
    nucleus GO:0005634 IEA
    cytosol GO:0005829 TAS
    PAN complex GO:0031251 IBA
    PAN complex GO:0031251 IDA
 Experiment description of studies that identified PAN3 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for PAN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 DDX6 1656
Affinity Capture-MS Homo sapiens
3 ANLN 54443
Affinity Capture-MS Homo sapiens
4 MECP2 4204
Affinity Capture-MS Homo sapiens
5 KIAA0430  
Affinity Capture-MS Homo sapiens
6 ASF1A 25842
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 KIF14 9928
Affinity Capture-MS Homo sapiens
8 C9orf163  
Affinity Capture-MS Homo sapiens
9 SVIL 6840
Two-hybrid Homo sapiens
10 TP53 7157
Affinity Capture-MS Homo sapiens
11 XPO1 7514
Affinity Capture-MS Homo sapiens
12 RC3H2  
Affinity Capture-MS Homo sapiens
13 ASF1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 CPEB1  
Proximity Label-MS Homo sapiens
15 NINL  
Proximity Label-MS Homo sapiens
16 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
17 PARK2  
Affinity Capture-MS Homo sapiens
18 TNRC6B  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
19 PABPC4 8761
Affinity Capture-MS Homo sapiens
20 TNRC6C  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
21 PAN2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
22 CLIC3 9022
Affinity Capture-MS Homo sapiens
23 PABPC1 26986
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
24 TNRC6A 27327
Affinity Capture-Western Homo sapiens
25 RPA3 6119
Proximity Label-MS Homo sapiens
26 HELZ 9931
Affinity Capture-MS Homo sapiens
27 PABPC5 140886
Affinity Capture-MS Homo sapiens
28 D2HGDH 728294
Affinity Capture-MS Homo sapiens
29 CADPS  
Affinity Capture-MS Homo sapiens
30 CLEC11A 6320
Affinity Capture-MS Homo sapiens
31 PRC1 9055
Affinity Capture-MS Homo sapiens
32 BICD1 636
Proximity Label-MS Homo sapiens
33 RC3H1 149041
Affinity Capture-MS Homo sapiens
34 PABPC3 5042
Co-fractionation Homo sapiens
35 GSPT1 2935
Affinity Capture-MS Homo sapiens
36 SLC9A3R2 9351
Affinity Capture-MS Homo sapiens
37 KIF20A 10112
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PAN3 is involved
PathwayEvidenceSource
Deadenylation of mRNA TAS Reactome
Deadenylation-dependent mRNA decay TAS Reactome
Metabolism of RNA TAS Reactome





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